An inverted virtual faculty development program for remote teaching: pilot for replication

Background: Due to the COVID 19 pandemic, all the universities worldwide are experiencing a paradigm shift to online learning. Baby boomers and Generation X need to cope with the challenging transformation, so an emerging need for a faculty development program was needed towards achieving the goal of that transformation. Objectives: To describe and assess an inverted virtual faculty development program (VFDP) that was designed and implemented for the first time in the school to equip educators with the necessary technology competencies for remote online learning. Methods: An interventional prospective study held in a university setting post need analysis conduction to prioritize the required technological skills for faculty members. The program was designed to integrate five essential skills needed to by faculty members to teach remotely. The intervention comprised attending five virtual sessions after watching a pre-distributed material, then evaluated using the Kirkpatrick model.Results: Almost 81% of faculty members completed the program and 80 % of participants were satisfied with the content of the program. There was a statistically significant difference between the perceived ability of the participants to share and record video lectures before and after the VFDP (p value <0.001). The percentage of the departments that applied the program components showed that 96% of them were able to record lectures. In addition, 80% of them were able to develop online quizzes. Conclusion: The inverted virtual faculty development program (VFDP) has supported the participating faculty in developing their needed technological competencies required to bridge the gap of remote teaching/learning

Improved bioavailability of timolol maleate via transdermal transfersomal gel: Statistical optimization, characterization, and pharmacokinetic assessment

AbstractTimolol maleate (TiM), a nonselective β-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from extensive first pass effect, resulting in a reduction of oral bioavailability (F%) to 50% and a short elimination half-life of 4h; parameters necessitating its frequent administration. The current study was therefore, designed to formulate and optimize the transfersomal TiM gel for transdermal delivery. TiM loaded transfersomal gel was optimized using two 23 full factorial designs; where the effects of egg phosphatidyl choline (PC): surfactant (SAA) molar ratio, solvent volumetric ratio, and the drug amount were evaluated. The formulation variables; including particle size, drug entrapment efficiency (%EE), and release rate were characterized. The optimized transfersomal gel was prepared with 4.65:1 PC:SAA molar ratio, 3:1 solvent volumetric ratio, and 13mg drug amount with particle size of 2.722μm, %EE of 39.96%, and a release rate of 134.49μg/cm2/h. The permeation rate of the optimized formulation through the rat skin was excellent (151.53μg/cm2/h) and showed four times increase in relative bioavailability with prolonged plasma profile up to 72h compared with oral aqueous solution. In conclusion, a potential transfersomal transdermal system was successfully developed and the factorial design was found to be a smart tool, when optimized

Spirulina Ameliorates Oxidative Damage and Inflammation in Rotenone-Induced Neurotoxicity in Male Mice

Background: Rotenone, a chemical compound produced naturally by leguminous plants, has conventionally been used as a pesticide by blocking the uptake of oxygen by body cells. Our study aimed to investigate the effect of spirulina on oxidative damage, inflammation, and neurotoxicity in male mice treated by rotenone.Methods: The experimental animals were divided into 5 groups. Group (I) served as control that received Dimethyl Sulfoxide (DMSO); Group (II) mice treated with rotenone (1.5 mg/kg, s.c.3 times per week); Group (III) mice received rotenone/L-dopa (25 mg/kg, P.O. daily); Group (IV) and Group (V) mice were treated with rotenone/spirulina (200 and 400 mg/kg, P.O. daily) respectively for two weeks.Results: Rotenone-treated mice indicated impaired motor coordination and activity in wire hanging, wood walking, open field, and stair tests. Furthermore, rotenone treatment caused elevation in striatal levels of Malondialdehyde (MDA), Nitric Oxide (NO), Tumor Necrosis Factor (TNF-α), Interleukin -1 beta (IL-1β), and caspase 3 and decrement in Bcl-2; dopamine and Glutathione (GSH) levels. Moreover, severe neuronal degeneration, striatal DNA fragmentation, and increased striatal 8-OHdG levels and MTH1 expression in the rotenone group. Additionally, spirulina treatment prevented rotenone-induced motor deficits striatal DNA fragmentation and demonstrated good restoration of the substantial neurons with reservation of the typical dark appearance. Besides, rotenone-induced biochemical changes were ameliorated by spirulina treatment as dopamine, Bcl-2, and GSH levels were increased, and striatal MDA, TNF-α, IL-1β, and caspase 3 levels were decreased.Conclusion: Natural products like spirulina could reverse rotenone-induced neurotoxicity in male mice due to their anti-inflammatory and antioxidant properties

On Hardy-Hilbert-type inequalities with α-fractional derivatives

In the current manuscript, new alpha delta dynamic Hardy-Hilbert inequalities on time scales are discussed. These inequalities combine and expand a number of continuous inequalities and their corresponding discrete analogues in the literature. We shall illustrate our results using Hölder's inequality on time scales and a few algebraic inequalities

The economic efficiency analysis of some rice mills in Egypt by using DEA and SFA

The main aim of this paper is measuring the economic efficiency of the rice mills public sector in Egypt and comparing the best company according to the economic efficiency. This aim is achieved by estimating the economic efficiency using Data Envelopment Analysis (DEA) and Stochastic Frontier Approach (SFA). This paper is based on some unpublished secondary data which is obtained from the rice mills of the public sector in Egypt from 2003 to 2014. The paper focuses on five main companies which are Domyat and Belqas, Dakahlia, Gharbia, Behiera and Kafer El-Sheikh. The most important results are that according to the dependent variable production (Y1), there is economic efficiency in rice mills Domyat and Belqas and Kafer El-Sheikh score by 1. While in rice mills Gharbia, Dakahlia and Behiera score by 40%, 49.3%, 38% (efficiency = 0.401, 0.507, and 0.622) respectively. While according to the dependent variable sales (Y2), there is economic efficiency in rice mills Domyat and Belqas, Gharbia, Dakahlia and Kafer El-Sheikh score by 1. While Behiera rice mills has economic inefficiency score by 21% (efficiency = 0.791)

Role of expression of atrial natriuretic peptide gene in essential hypertension among Egyptian patients

Introduction: Essential Hypertension has been a great burden on public health services for a long time, with many life-threatening complications. Therefore, we decided to study Atrial Natriuretic peptide (ANP) gene expression as one of the most important blood pressure controlling genes, in order to use ANP gene as a potential diagnostic or therapeutic marker in the near future.Methods: One hundred essential hypertensive patients and 100 normotensive controls were included. Study Subjects were subjected to ANP gene expression analysis, together with blood pressure measurement, Lab investigations, and BMI analysis.Results: There was a statistical difference between ANP gene expression and blood pressure, with lower ANP gene expression level (median of 0.3) being present among hypertensive patients and higher ANP gene expression level (median of 1.6) among normotensive controls (p < 0.001).Discussion: We proved that ANP gene expression to be low in essential hypertension patients compared with normotensive individuals

The economic efficiency analysis of some rice mills in Egypt by using DEA and SFA

The main aim of this paper is measuring the economic efficiency of the rice mills public sector in Egypt and comparing the best company according to the economic efficiency. This aim is achieved by estimating the economic efficiency using Data Envelopment Analysis (DEA) and Stochastic Frontier Approach (SFA). This paper is based on some unpublished secondary data which is obtained from the rice mills of the public sector in Egypt from 2003 to 2014. The paper focuses on five main companies which are Domyat and Belqas, Dakahlia, Gharbia, Behiera and Kafer El-Sheikh. The most important results are that according to the dependent variable production (Y1), there is economic efficiency in rice mills Domyat and Belqas and Kafer El-Sheikh score by 1. While in rice mills Gharbia, Dakahlia and Behiera score by 40%, 49.3%, 38% (efficiency = 0.401, 0.507, and 0.622) respectively. While according to the dependent variable sales (Y2), there is economic efficiency in rice mills Domyat and Belqas, Gharbia, Dakahlia and Kafer El-Sheikh score by 1. While Behiera rice mills has economic inefficiency score by 21% (efficiency = 0.791)

CLINICAL SIGNIFICANCE OF PROCALCITONIN AND C-REACTIVE PROTEIN IN THE PREDICTION OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

  Objective: This work was delineated to assess procalcitonin (PCT) and C-reactive protein (CRP) as prognostic markers for cardiovascular complication in type 2 diabetic patients.Methods: Forty diabetic patients without cardiovascular disease (CVD), 40 diabetic patients with CVD, and 20 healthy control counterparts were participated in this study. Serum PCT and CRP levels were assayed and correlated with metabolic parameters. Receiver operating characteristic (ROC) curve analysis was done for each biochemical marker.Results: The mean level of PCT was 707.17±99.19 ng/l in diabetic patients versus 881.30±123.56 ng/l for the cardio-diabetic patients (p<0.0001). The mean value of CRP was 34.43±17.27 mg/l in diabetic patients versus 50.32±20.19 mg/l for the cardio-diabetic patients (p=0.0003). PCT levels were significantly amplified in the cardio-diabetic patients with increasing CRP, triglycerides (TG), fasting blood glucose (FBG), and cholesterol (p=0.004, 0.0005, 0.002, and 0.01, respectively). CRP levels were significantly enhanced in the cardio-diabetic patients with increasing TG, FBG, cholesterol, and microalbumin (p=0.002, 0.047, 0.003, and 0.001 respectively). ROC curve analysis for PCT and CRP revealed that the area under curve (AUC) was 0.878 and 0.727, respectively. These findings indicate the good validity of the above biomarkers especially PCT as a prognostic marker for cardiovascular complication in type 2 diabetic patients.Conclusion: This study evidences the usefulness of measuring serum levels of PCT and CRP in diagnosis of cardiovascular complication in type 2 diabetic patients

Study The Applications of Water Deficiency Levels and Ascorbic Acid Foliar on Growth Parameters and Yield of Summer Squash Plant (Cucurbita pepo L.)

Two field experiments study during 2015 and 2016 summer seasons on sandy loam soil under drip irrigation system by Nile river water, at the Agricultural Research and Production Station National Research Centre, El- Nubaria region, EL- Beheira Governorate,  Egypt. This study focused on the applications of different water deficiency levels (100, 80 and 60% of F.C. i.e. field capacity) and ascorbic acid (AsA) spraying foliar application with different concentrations (0, 50 and 100 ppm) as antioxidant on growth parameters and yield as well as photosynthetic pigments content of summer squash plants (Cucurbitapepo L.cv. Eskandrani). Results indicated that, decreasing water levels caused a significant reduction in the all tested growth and yield parameters, i.e., canopy weight, root weight, number of leaves, leaves fresh weight and leaf area as well as photosynthetic pigments content (total chl., and carotenoids), total yield, fruit weight and length. While increasing ascorbic acid spraying foliar application levels as antioxidant significantly increased the aforementioned parameters in the two seasons as compared with control. On the other hand, decreasing water levels caused a significant increasing in leaf proline content, leaf cell sap osmotic pressure, dry matter % and fruit TSS in the two growing seasons as compared with control.Keywords: water stress, water deficiency, ascorbic acid, antioxidant, growth, yield, summer squash plant and Cucurbita pepo.

Caracterización de endemismos mediterráneos en la flora egipcia

The Mediterranean Basin is the world’s second richest hotspot, and one of the most important locations on the planet for endemic taxa. However, there is no available up-to-date list of Mediterranean endemics. Available data are frequently insufficient or outdated. Therefore, this study aimed at delimiting the Mediterranean floristic region in Egypt, screening its Mediterranean endemics, and determining their habitats, life forms, flowering periods, dispersal types and phyto-geographical distribution. From a list of 275 Mediterranean endemic taxa in Egypt compiled from literature, this study reduced it to 57 taxa (including species, subspecies and varieties; 20.7%) belonging to 46 genera and 22 families. Fifteen major habitats harbored Mediterranean endemics in Egypt, with coastal dunes (17 taxa = 29.8%) and non-saline depressions (16 taxa = 28.1%) being the most represented. Moreover, the Mareotis (west) subsector was the richest (46 taxa = 80.7%). The largest number of taxa was recorded in North African sub-region (52 taxa = 91.2%), followed by Eastern (levant) sub-region (36 taxa = 63.2%). Therophytes were the most recorded life form, while ballochory was the most represented dispersal type. In conclusion, it is crucial to shed the light on Mediterranean endemics and provide an up-to-date documented database to help future management plan that support their conservation and sustainable use.La cuenca Mediterránea es el segundo hotspot más rico del mundo y uno de los lugares más importantes del planeta en taxones endémicos. Sin embargo, no existe una lista actualizada de taxones endémicos mediterráneos. Los datos disponibles son frecuentemente insuficientes o están desactualizados. Por tanto, nuestro objetivo fue delimitar la región florística mediterránea en Egipto, seleccionar sus plantas endémicas mediterráneas y determinar sus hábitats, formas de vida, periodos de floración, tipos de dispersión y distribución fitogeográfica. Partiendo de una lista preliminar de 275 taxones endémicos del Mediterráneo presentes en Egipto recopilada de la bibliografía, este estudio redujo ese número a 57 taxones (incluyendo especies, subespecies y variedades; 20.7%) pertenecientes a 46 géneros y 22 familias. Las plantas endémicas mediterráneas de Egipto viven en quince hábitats principales, siendo los más representativos las dunas costeras (17 taxones = 29.8%) y las depresiones no salinas (16 taxones = 28.1%). El subsector Mareotis (al oeste) fue el más rico (46 taxones = 80.7%), mientras que el mayor número de taxones se registró en la subregión del norte de África (52 taxones = 91.2%), seguida de la subregión del este (levante) (36 taxones = 63.2%). Los terófitos fueron la forma vital más registrada y la balocoria el tipo de dispersión más común. En conclusión, es crucial arrojar luz sobre las plantas endémicas del Mediterráneo y proporcionar una base de datos documentada y actualizada que ayude a planificar una gestión futura que promueva su conservación y uso sostenible