Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats

Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties. This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and nitric oxide (NO)–deficient hypertensive rats. OPLE was administered orally (500 mg=kg of body weight=day) to normotensive Wistar rats and Nx-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. OPLE significantly (P < .05) attenuated blood pressure increases, increased serum NO, reduced lipid peroxidation, and showed antioxidant effects in NO-deficient hypertensive rats. OPLE decreased the coronary arteriole wall-to-lumen ratio to near normal values under NO deficiency. Although OPLE showed good antihypertensive and antioxidant effects under NO deficiency, it was not hypotensive to normal rats and produced no chronic cardiovascular toxicity in any of the rats throughout the 12-week study. This is the first report on the in vivo antihypertensive properties of green tea catechins extracted from an alternative source, namely, oil palm leaf, for use as a medicinal food for hypertension and cardiovascular ailments

Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats' kidney and liver

Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation, antioxidant and cardiovascular properties. This study evaluated the beneficial or toxic effects of OPLE on the liver and kidneys of normal and hypertensive rats. The OPLE (500 mg/kg body weight) were administered orally to normal Wistar Kyoto rats, spontaneously hypertensive rats (SHR) and N-ω-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. The OPLE reduced hypertension in NO-deficient rats, but not in SHR. Hepatocytes or glomeruli injury and oxidative markers were high in hypertensive rats compared to normal rats, and they were reduced (p < 0.05) by OPLE supplementation, even when there was no blood pressure reduction. Unlike the hypertensive drug captopril, the OPLE showed no toxicity to normal rats. The dose reported is equivalent 0.5 g of catechins/day for humans or 2.5 cups of tea. The catechins are from an abundant alternative source for potential use as functional food

Kenali, Cegah dan Atasi Dislipidemia Recognize, Prevent, and Eradicate Dyslipidemia

Dislipidemia adalah kelainan metabolisme lipid yang ditandai dengan peningkatan maupun penurunan satu atau lebih fraksi lipid dalam darah. Peningkatan kadar kolesterol total dan LDL darah dapat disebabkan oleh peningkatan konsumsi lemak jenuh dan kolesterol yang tinggi dalam makanan. Pada perjalanan dislipidemia, apabila kadar kolesterol tidak terkontrol dengan baik, maka akan meningkatkan risiko terjadi nya komplikasi baik akut maupun kronis. Pada umumnya, sebagian masyarakat telah mengenal perihal kolesterol secara umum namun mungkin belum memahami bagaimana cara mencegah dan mengatasi kadar kolesterol darah yang tinggi. Edukasi yang baik disertai terapi nutrisi, jasmani dan tatalaksana farmakologi diharapkan dapat mengendalikan progresifitas penyakit dislipidemia dan komplikasinya. Oleh karena itu pengabdian masyarakat berbasis webinar ini diadakan selain untuk meningkatkan keilmuan, juga diharapkan dapat meningkatkan kesadaran akan bahaya dari penyakit dislipidemia. Kegiatan webinar ini menargetkan mahasiswa UTA45 dan masyarakat umum dengan luaran yang diharapkan yaitu dapat meningkatkan pengetahuan tentang penyakit dislipidemia. Webinar dengan metode presentasi dan tanya jawab yang dilaksanakan pada 27 April 2022. Total peserta yang mengikuti kegiatan webinar dengan mengisi absen secara online sebanyak 66 peserta. Persentase rata – rata total skor prestest perserta sebesar 70,2% dan rata – rata skor posttest sebesar 79,6% dapat dilihat bahwa terjadi peningkatan skor posttest sebesar 9,4%

Use of a neuroprotective extract and pharmaceutical preparation thereof.

The present invention disclosed an extract having neuroprotective property prepared from a plant of the family Palmae, which is capable in preserving neurons against damage caused by oxidation, ageing and/ or nitric oxide deficiency. Also disclosed is a pharmaceutical preparation and a comestible preparation comprising the extract as an active ingredient in a therapeutically effective amount to protect against neuron damage

Extract from palm leaves and a method for producing the same

A method for preparing an herbal extract comprises the steps of pre-treating foliages derives from a plant of Arecaceae family: extracting the pre-treated foliages by using a polar solvent: removing the pre-treated foliages from the used polar solvent; and concentrating the used polar solvent to acquire the herbal extract

Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation,antioxidant and cardiovascular properties. This study evaluated the beneficial or toxic effects of OPLE on the liver and kidneys of normal and hypertensive rats. The OPLE (500 mg/kg body weight) were administered orally to normal Wistar Kyoto rats, spontaneously hypertensive rats (SHR) and N-x-nitro-L-arginine methyl ester (L-NAME)-induced NO-deficient hypertensive rats. The OPLE reduced hypertension in NO-deficient rats, but not in SHR. Hepatocytes or glomeruli injury and oxidative markers were high in hypertensive rats compared to normal rats, and they were reduced (p < 0.05) by OPLE supplementation, even when there was no blood pressure reduction. Unlike the hypertensive drug captopril,the OPLE showed no toxicity to normal rats. The dose reported is equivalent 0.5 g of catechins/ day for humans or 2.5 cups of tea. The catechins are from an abundant alternative source for potential use as functional food

Extract of palm leaf and a composition comprising the same for increasing bone mineral density and arterial homeostasis

The present invention discloses an extract of palm leaf and a composition containing the same as an effective ingredient for the prevention and treatment of osteoporosis. In an embodiment, the composition further includes a seaweed extract. The composition disclosed herein possesses synergistic activities of promoting bone mineral and/or calcium density, as well as arterial integrity and homeostasis in mammals, so that the composition can be effectively used for the prevention and treatment of osteoporosis