Study of the Antitumor Activity of the Drug Dekoglitz on Two Tumors and Some Aspects of Its Mechanism of Action

Aim: Evaluation of the antitumor activity of the new drug Dekoglitz in animals with tumor strains of Sarcoma 45 in comparison with the drug dekocin, from which it was obtained, as well as with 5-fluorouracil and etoposide, and on ovarian tumors (OT) in comparison with the drug dekocin and identification of the effect of Dekoglitz on NA synthesis and internucleosomal DNA degradation. Methods: The study of preparations was carried out on 68 outbred rats with transplanted C-45 and OT tumors.The alkylating effect of the drugs was studied on cells tumor of Sarcoma 180. Results: The antitumor activity of dekoglitz on Sarcoma 45 was high, about 98/96%, with a remission rate of 80%. Its effect was 28-24% higher than that of dekocin. On OT, the effect of decoglitz with intraperitoneal administration reached 89/76% with a remission rate of 40%, with oral administration 96/86% with a remission rate of 60%. Conclusion:The study of the new drug Dekoglitz on animals with a tumor of Sarcoma 45 revealed its higher activity (by 20-27%) in comparison with the original Dekocin, 5-fluorouracil and etoposide with a lower level of side effects. On OT, the effect of Dekoglitz was 35-40% higher, especially after oral administration. Apparently, the great ability to suppress the synthesis of NA and carry out internucleosomal degradation and fragmentation of tumor DNA by the new drugs dekoglitz explains its antitumor efficacy,which is greater than that of Dekocin (K-18) in experiments on tumors

Symmetric - Asymmetric correlation of the category "beauty" and the categories "truth"/"verity"

The relevance of the studied issue is conditioned by the urgent society need for a more detailed design of the value and anti-value system in the aspect of philosophy, sociology, politics and linguistics. Earlier we offered the following universal system of conventional values reflected in the language (at the level of phraseology): 1. Life - Death. 2. Health - Disease - vital values and anti-values (< Latin vita - life, vitalis - vital). 3. Happiness - Misfortune - hedonistic / spiritual value and its disvalue (< Greek hedone - 'pleasure'). 4. Homeland - Foreign land - a sacred value and its disvalue. In philosophy, sacred - "a mysterious conquering force" which "inspires and makes happy at the same time" [FES: 407]. 5. Work - Rest. Idleness - social and utilitarian value and disvalue (< Latin socialis - a common, public, utilitarian < Greek utilitas - benefit, profit) [FES: 470]. 6. Wealth - Poverty - material and utilitarian value and disvalue. 7. Mind - Stupidity - intellectual and cognitive value and disvalue pointing a man intelligence (< lat. intellektus - mind, intellect), knowledge, cognition (< Latin cognitio - knowledge, cognition). 8. Truth - Lie - the moral and ethical value and disvalue. The doctrine of morality, morals represented by ethics (< Greek ethiká, from ethos - custom, moral character). 9. Laughter - Crying - emotional and utilitarian value and disvalue. They reveal the benefit of emotions (Laughter) or their harm (Crying) (< lat. emoveo - stun, excite;. < French émotion - excitement). 10. Paradise - Hell. Idioms of heaven and hell reflect the idea of religious values and disvalues [1]. The paper proposes a new dyad of value and disvalue associated with aesthetics: beauty - ugliness, absence of beauty. The aesthetic category of "beauty" is analyzed in correlation with the moral and ethical category of "truth" / "righteousness": symmetry at compliance; at non-compliance with the category of "truth" / "righteousness" (asymmetry)

Symmetric - Asymmetric correlation of the category "beauty" and the categories "truth"/"verity"

The relevance of the studied issue is conditioned by the urgent society need for a more detailed design of the value and anti-value system in the aspect of philosophy, sociology, politics and linguistics. Earlier we offered the following universal system of conventional values reflected in the language (at the level of phraseology): 1. Life - Death. 2. Health - Disease - vital values and anti-values (< Latin vita - life, vitalis - vital). 3. Happiness - Misfortune - hedonistic / spiritual value and its disvalue (< Greek hedone - 'pleasure'). 4. Homeland - Foreign land - a sacred value and its disvalue. In philosophy, sacred - "a mysterious conquering force" which "inspires and makes happy at the same time" [FES: 407]. 5. Work - Rest. Idleness - social and utilitarian value and disvalue (< Latin socialis - a common, public, utilitarian < Greek utilitas - benefit, profit) [FES: 470]. 6. Wealth - Poverty - material and utilitarian value and disvalue. 7. Mind - Stupidity - intellectual and cognitive value and disvalue pointing a man intelligence (< lat. intellektus - mind, intellect), knowledge, cognition (< Latin cognitio - knowledge, cognition). 8. Truth - Lie - the moral and ethical value and disvalue. The doctrine of morality, morals represented by ethics (< Greek ethiká, from ethos - custom, moral character). 9. Laughter - Crying - emotional and utilitarian value and disvalue. They reveal the benefit of emotions (Laughter) or their harm (Crying) (< lat. emoveo - stun, excite;. < French émotion - excitement). 10. Paradise - Hell. Idioms of heaven and hell reflect the idea of religious values and disvalues [1]. The paper proposes a new dyad of value and disvalue associated with aesthetics: beauty - ugliness, absence of beauty. The aesthetic category of "beauty" is analyzed in correlation with the moral and ethical category of "truth" / "righteousness": symmetry at compliance; at non-compliance with the category of "truth" / "righteousness" (asymmetry)

La Patrie : journal quotidien, politique, commercial et littéraire

09 novembre 18691869/11/09 (A29)

Bentonite clays of the Central Kyzylkum and their material composition and engineering and geological properties, Uzbekistan

The authors consider the conditions of occurrence, composition, and properties of the Eocene clays of the Paleogene, common in the northern part of Tamdytau, which were the foundation of the structures. The present study of the authors is aimed at studying the problem of the long-term interaction of Eocene clays with water and identifying the features of changes in their material composition and properties; the variability of the composition, properties of clays, and the reasons for these changes are analyzed. The main factors determining the differences in the composition and properties of Paleogene clays are: genetic - different salinity of the sea basin or less saline at which the reservoirs were connected with the open sea; zonal-climatic - different humidity and other physical properties. So far, no unified methodology has been developed for predicting the composition and properties of clays at the base of structures when interacting with water. The results of granulometric analysis established that Paleogene clays are classified as highly dispersed soils containing more than 55% of clay particles. Analysis of the diffraction pattern showed that the clay fraction of the studied samples contain montmorillonite (M), hydromica (H), kaolinite (K), mixed-layer formations of the montmorillonite-hydromica series

New cycloartane glycoside from astragalus mucidus

A new glycoside was isolated from the aerial part of Astragalus mucidus. Its chemical structure was characterized as a cycloartane triterpenoid using PMR and 13C NMR spectra (COSY, HMQC, HMBC). The glycoside was called cyclomucidoside A

Application of hyperspectral and multispectral datasets for mineral mapping

In this study, hyperspectral datasets are simulated from multispectral data using a spectral reconstruction approach which is a sensor-independent technique. This technique makes use of information from atmospherically corrected multispectral Remote Sensing (MRS) data and normalized ground spectra for the simulation of HRS data. In this study EO-1, the ALI dataset was used for the simulation of hyperspectral Remote Sensing (HRS) data to discover the Udaipur region’s unique minerals. A total of 61 spectral bands with 10 nm bandwidth were simulated. The simulated HRS data were validated using visual interpretation, statistical and classification approaches. Simulated HRS data from EO-1 Advanced Land Imager (ALI) has shown a high correlation with EO-1 Hyperion data. Spectral Angle Mapper (SAM) classification was also performed on simulated hyperspectral data for mineral mapping. It was observed that simulated hyperspectral data have shown comparable results with Hyperion and are better than their corresponding multispectral datasets