3,743 research outputs found
Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated that hMLH1 and hPMS2 are widely expressed nuclear proteins with a distribution pattern very similar to that previously described for hMSH2. These observations showing similar localization of hMLH1 and hPMS2 with hMSH2 are consistent with the biochemical function of these proteins in DNA mismatch repair
Theory for the Doping Dependence of Spin Fluctuation Induced Shadow States in High-T Superconductors
We analyze the doping dependence of the intensity and energetical position of
shadow states in high -T superconductors within the 2D Hubbard model and
using our recently developed numerical method for the self consistent summation
of bubble and ladder diagrams. It is shown that shadow states resulting from
short range antiferromagnetic correlations occur for small but finite
excitation energies which decrease for decreasing doping, reflecting a
dynamically broken symmetry with increasing lifetime. Simultanously, the
intensity of these new states increases, the quasiparticle dispersion is
strongly flattened, and a pseudogap in the density of states occurs. Finally,
we discuss the importance of flat bands at the Fermi level and nesting of the
Fermi surface as general prerequisites for the observability of shadow states.Comment: 9 pages (TeX) with 3 figures (Postscript
Acute transverse myelitis in Lyme neuroborreliosis
Introduction: Acute transverse myelitis (ATM) is a rare disorder (1-8 new cases per million of population per year), with 20% of all cases occurring in patients younger than 18years of age. Diagnosis requires clinical symptoms and evidence of inflammation within the spinal cord (cerebrospinal fluid and/or magnetic resonance imaging). ATM due to neuroborreliosis typically presents with impressive clinical manifestations. Case presentation: Here we present a case of Lyme neuroborreliosis-associated ATM with severe MRI and CSF findings, but surprisingly few clinical manifestations and late conversion of the immunoglobulin G CSF/blood index of Borrelia burgdorferi sensu lato. Conclusion: Clinical symptoms and signs of neuroborrelial ATM may be minimal, even in cases with severe involvement of the spine, as shown by imaging studies. The CSF/blood index can be negative in the early stages and does not exclude Lyme neuroborreliosis; if there is strong clinical suspicion of Lyme neuroborreliosis, appropriate treatment should be started and the CSF/blood index repeated to confirm the diagnosi
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