Direct Laser Sintering of Borosilicate Glass

Despite the advantages that selective laser sintering (SLS) offers in terms of material availability, many materials have yet to be explored for feasibility and even fewer are available on a commercial basis. This paper presents initial investigations for one such material, borosilicate glass, which could be of particular interest to filter manufacturers because it presents an attractive alternative to the conventional, time-consuming way of producing filters of various porosity classes. Process results are presented including a determination of the optimal parameter window and the effect of processing parameters on the density and surface quality. The effects of thermal post-processing and the inclusion of an additive are also discussed.Mechanical Engineerin

Direct Laser Sintering of Ceramics

For more than one decade layer manufacturing technologies assist the development of new products. Due to a layer-wise build-up of a three-dimensional geometry, nearly every complex design is producible in a short period of time. Selective Laser Sintering is a powderbased technique to produce plastic prototypes (Rapid Prototyping) or metal mould inserts (Rapid Tooling). The laser sintering of ceramic powder is not yet commercialized but applications could be both Rapid Prototyping and Rapid Tooling. The former involves the laser sintering of investment casting shells and cores to cast metal prototypes and the latter the laser sintering of ceramic master patterns for metal spray forming of steel mould inserts. The advantage compared to actual processes are a faster availability of the final product. To facilitate these applications, special ceramic powders as well as new process parameter combinations were investigated. This paper will present achieved results within the abovedescribed applications.Mechanical Engineerin

Induced Polyakov supergravity on Riemann surfaces of higher genus

An effective action is obtained for the $N=1$, $2D-$induced supergravity on a compact super Riemann surface (without boundary) $\hat\Sigma$ of genus $g>1$, as the general solution of the corresponding superconformal Ward identity. This is accomplished by defining a new super integration theory on $\hat\Sigma$ which includes a new formulation of the super Stokes theorem and residue calculus in the superfield formalism. Another crucial ingredient is the notion of polydromic fields. The resulting action is shown to be well-defined and free of singularities on \sig. As a by-product, we point out a morphism between the diffeomorphism symmetry and holomorphic properties.Comment: LPTB 93-10, Latex file 20 page

On the holomorphic factorization for superconformal fields

For a generic value of the central charge, we prove the holomorphic factorization of partition functions for free superconformal fields which are defined on a compact Riemann surface without boundary. The partition functions are viewed as functionals of the Beltrami coefficients and their fermionic partners which variables parametrize superconformal classes of metrics.Comment: 5 pages, LATEX, MPI-Ph/92-7

The Polyakov action on the supertorus

A consistent method for obtaining a well-defined Polyakov action on the supertorus is presented. This method uses the covariantization of derivative operators and enables us to construct a Polyakov action which is globally defined.Comment: 15 pages LaTe

Determinants of methicillin-susceptible Staphylococcus aureus native bone and joint infection treatment failure: a retrospective cohort study.

BACKGROUND: Although methicillin-susceptible Staphylococcus aureus (MSSA) native bone and joint infection (BJI) constitutes the more frequent clinical entity of BJI, prognostic studies mostly focused on methicillin-resistant S. aureus prosthetic joint infection. We aimed to assess the determinants of native MSSA BJI outcomes. METHODS: Retrospective cohort study (2001-2011) of patients admitted in a reference hospital centre for native MSSA BJI. Treatment failure determinants were assessed using Kaplan-Meier curves and binary logistic regression. RESULTS: Sixty-six patients (42 males [63.6%]; median age 61.2 years; interquartile range [IQR] 45.9-71.9) presented an acute (n = 38; 57.6%) or chronic (n = 28; 42.4%) native MSSA arthritis (n = 15; 22.7%), osteomyelitis (n = 19; 28.8%) or spondylodiscitis (n = 32; 48.5%), considered as "difficult-to-treat" in 61 cases (92.4%). All received a prolonged (27.1 weeks; IQR, 16.9-36.1) combined antimicrobial therapy, after surgical management in 37 cases (56.1%). Sixteen treatment failures (24.2%) were observed during a median follow-up period of 63.3 weeks (IQR, 44.7-103.1), including 13 persisting infections, 1 relapse after treatment disruption, and 2 super-infections. Independent determinants of treatment failure were the existence of a sinus tract (odds ratio [OR], 5.300; 95% confidence interval [CI], 1.166-24.103) and a prolonged delay to infectious disease specialist referral (OR, 1.134; 95% CI 1.013-1.271). CONCLUSIONS: The important treatment failure rate pinpointed the difficulty of cure encountered in complicated native MSSA BJI. An early infectious disease specialist referral is essential, especially in debilitated patients or in presence of sinus tract

d=2, N=2 Superconformal Symmetries and Models

We discuss the following aspects of two-dimensional N=2 supersymmetric theories defined on compact super Riemann surfaces: parametrization of (2,0) and (2,2) superconformal structures in terms of Beltrami coefficients and formulation of superconformal models on such surfaces (invariant actions, anomalies and compensating actions, Ward identities).Comment: 43 pages, late

W-algebras from symplectomorphisms

It is shown how $W$-algebras emerge from very peculiar canonical transformations with respect to the canonical symplectic structure on a compact Riemann surface. The action of smooth diffeomorphisms of the cotangent bundle on suitable generating functions is written in the BRS framework while a $W$-symmetry is exhibited. Subsequently, the complex structure of the symmetry spaces is studied and the related BRS properties are discussed. The specific example of the so-called $W_3$-algebra is treated in relation to some other different approaches.Comment: LaTex, 25 pages, no figures, to appear in Journ. Math. Phy

Invasive pulmonary aspergillosis in chronic obstructive pulmonary disease: an emerging fungal pathogen

ABSTRACTAcute invasive pulmonary aspergillosis occurs predominantly in immunocompromised hosts, with increasing numbers of cases of invasive aspergillosis among patients with chronic obstructive pulmonary disease (COPD) being reported. Among 13 cases of invasive aspergillosis diagnosed in COPD patients admitted to the intensive care unit with acute respiratory distress, the only risk factor for invasive fungal infection was corticosteroid treatment. Invasive aspergillosis should be suspected in COPD patients receiving steroid treatment who have extensive pulmonary infiltrates. Survival depends on rapid diagnosis and early appropriate treatment. A decrease or interruption of steroid treatment should be considered as part of the overall therapeutic strategy

Ocean redox structure across the Late Neoproterozoic Oxygenation Event: A nitrogen isotope perspective

International audienceThe end of the Neoproterozoic Era (1000 to 541 Ma) is widely believed to have seen the transition from a dominantly anoxic to an oxygenated deep ocean. This purported redox transition appears to be closely linked temporally with metazoan radiation and extraordinary perturbations to the global carbon cycle. However, the geochemical record of this transition is not straightforward, and individual data sets have been variably interpreted to indicate full oxygenation by the early Ediacaran Period (635 to 541 Ma) and deep ocean anoxia persevering as late as the early Cambrian. Because any change in marine redox structure would have profoundly impacted nitrogen nutrient cycling in the global ocean, the N isotope signature of sedimentary rocks (δ15Nsed) should reflect the Neoproterozoic deep-ocean redox transition. We present new N isotope data from Amazonia, northwest Canada, northeast Svalbard, and South China that span the Cryogenian glaciations (∼750 to 580 Ma). These and previously published data reveal a Nisotope distribution that closely resembles modern marine sediments, with a mode in δ15N close to +4 and range from −4 to +11. No apparent change is seen between the Cryogenian and Ediacarian. Data from earlier Proterozoic samples show a similar distribution, but shifted slightly towards more negative δ15N values and with a wider range. The most parsimonious explanation for the similarity of these Nisotopedistribution is that as in the modern ocean, nitrate (and hence O2) was stable in most of the middle–late Neoproterozoic ocean, and possibly much of Proterozoic Eon. However, nitrate would likely have been depleted in partially restricted basins and oxygen minimum zones (OMZs), which may have been more widespread than in the modern ocean