P63 marker Expression in Usual Skin Cancers Compared With Non Tumoral Skin Lesions

Background: Non-melanoma skin cancers including basal cell carcinoma and squamous cell carcinoma are the most common malignant diseases in human. The aim of this study was to determine the expression of the P63 marker in common skin cancers and non-tumoral skin lesions and compared the difference between them. Materials and Methods: In this cross-sectional study, sampling was performed from the archive of sample blocks from patients admitted in Shahid Mohammadi Hospital during 2010-2011. Sixty samples (including 30 samples of non-tumoral skin lesions and 30 samples including basal cell carcinoma and squamous cell carcinoma) were studied. The evaluation of p63 gene expression was performed using immunohistochemistry method. Student’s T-test and Chi-square test were used for analysis of the data. Results: P63 gene were expressed in 4 cases (13.33 %) of non_tumoral lesions and all tumoral lesions (100%). In tumoral lesions, 5 cases (16.66 %) showed 1+ severity expression, 11 cases (36.66%) 2+severity expression and 14 cases (46.66 %) 3+severity expression. All 4 non-tumoral lesions showed 1+severity expression of P63gene. Conclusion: The results of this study indicated that the frequency and severity of gene expression of P63 could be used for differentiation between basal cell carcinoma and squamous cell carcinoma as well as non-tumoral skin lesions

Data ondaily fluoride intakebasedondrinking waterconsumptionpreparedbyhousehold desalinatorsworkingbyreverseosmosisprocess

In thisdataarticle,weevaluatedthedaily fluoride contentsin20 householddesalinatorsworking byreverseosmosis(RO)1 processin Bushehr,Iran.Theconcentrationlevelsof fluoride ininletandoutlet watersweredeterminedbythestandardSPADNSmethodusinga spectrophotometer(M501SingleBeamScanningUV/VIS,UK).The fluoridecontentinoutletwaterswerecomparedwithEPAandWHO guidelinesfordrinkingwater

Data ondaily fluoride intakebasedondrinking waterconsumptionpreparedbyhousehold desalinatorsworkingbyreverseosmosisprocess

In thisdataarticle,weevaluatedthedaily fluoride contentsin20 householddesalinatorsworking byreverseosmosis(RO)1 processin Bushehr,Iran.Theconcentrationlevelsof fluoride ininletandoutlet watersweredeterminedbythestandardSPADNSmethodusinga spectrophotometer(M501SingleBeamScanningUV/VIS,UK).The fluoridecontentinoutletwaterswerecomparedwithEPAandWHO guidelinesfordrinkingwater. & 2016TheAuthors.PublishedbyElsevierInc.Thisisanopenaccess article undertheCCBYlicens

Data onFe(II)biosorptiononto Sargassum hystrix algae obtainedfromthePersianGulfinBushehr Port, Iran

In thisarticle,weused Sargassum hystrix algae asbiosorbentfor removalofFe(II)fromaqueoussolutionsthatwascollectedalong the PersianGulfcoastline,Bushehr,Iran.Theconcentrationlevelof remaining Fe(II)inthesampleswasmeasuredbyusing flame atomic absorptionspectrometry(FAAS,VarianAA240,Australia). The isotherms,kineticsandmodelingdataofFe(II)biosorption onto Sargassum hystrix werealsopresented

P63 marker Expression in Usual Skin Cancers Compared With Non Tumoral Skin Lesions

Background: Non-melanoma skin cancers including basal cell carcinoma and squamous cell carcinoma are the most common cancers in human. The aim of this study was to determine the expression of P63 marker in usual skin cancers compared with non-tomoral skin lesions. Materials and Methods: In this cross-sectional study, sampling was performed from archival blocks of Shahid Mohammadi hospital patients during 2010-2011. 60 samples (including 30 samples of non tumoral skin lesions and 30 samples of basal cell carcinoma and squamous cell carcinoma) were studied and evaluation of p63 gene expression was done with Immunohistochemistry method. T-test and Chi-square were used for analysis of data. Results: P63 gene were expressed in 4 cases (13.33 %) of non tumoral lesions and all tumoral lesions (100 %). In tumoral lesions, 5 cases (16.66 %) showed 1+ severity experssion, 11 cases (36.66%) 2 + severity experssion and 14 cases (46.66 %) 3+severity experssion. All 4 non tumoral lesions shoed 1+ severity experssion of P63gene. Conclusion: The results of this study indicated that the incidence and severity of gene expression of P63 can be use for differentiation between basal cell carcinoma and squamous cell carcinoma as well as non-tumoral skin lesions.&nbsp

A Comparative Analysis of Saffron and Methylprednisolone on Bleomycin-Induced Pulmonary Fibrosis in Rats

Background: The purpose of this study was to compare the effects of saffron and methylprednisolone on bleomycin-induced pulmonary fibrosis in rats. Methods: This study was conducted in Bushehr, southern Iran in 2017.The animals were divided into four groups of five rats each. Three groups were injected with a single intratracheal dose of bleomycin (5 mg/kg). The fourth group was administered with normal saline at the same volume (200 µl). Saffron extract dissolved in water was given to one group (100 mg /body weight) orally while intraperitoneal injection of methylprednisolone (2.5 mg/kg) injected to another one for 16 days. The rats were sacrificed 28 days following surgery and their right and left lungs were removed and washed for measuring lung indices, myeloperoxidase activities and finally histopathological examination. Results: Injection of bleomycin caused decrement of body weight aggravated by intraperitoneal methylprednisolone treatment. Lung indices were increased in the bleomycin-treated group compared with the control, while methylprednisolone, unlike saffron, had no preventive effects on it. Both saffron and methylprednisolone treatment prevented the increase in lung myeloperoxidase as a destructive enzyme. In addition, excessive collagen deposition and thickening of alveolar septa were significantly prevented with saffron treatment as compared to methylprednisolone injection following hematoxylin and eosin staining. Conclusion: Saffron with established antioxidant properties could prevent some detrimental effects in bleomycin-induced pulmonary fibrosis even more than methylprednisolone injection known as a standard therapy in this murine model. More investigations must be carried out to examine the beneficial or harmful effects of this remedy

The effect of land use configurations on concentration, spatial distribution, and ecological risk of heavy metals in coastal sediments of northern part along the Persian Gulf

In the present study, a total of 41 sediment samples were collected from the areas with different land uses: industrial (IS), urban (US), agricultural (AGS), and natural field (NS) in the northern coasts along the Persian Gulf from November 2016 to January 2017. Samples were analyzed to determine the concentration of heavy metals (Zn, Cu, Pb, Cd, Cr, and Ni). The mean concentration of Ʃ6 heavy metals in the samples taken from IS, US, AGS, NS were 2300.24, 251.02, 553.21, and 40.93 mg/kg, respectively. The predominant metals were Zn, Cu, and Pb and the mean concentrations of Ʃ3 metals (Zn, Cu, and Pb) in IS, US, AGS, NS areas were 2245.6, 241.44, 529.61, and 36.98 mg/kg, respectively. The results indicated that the mean concentrations of Ʃ6Metals/Ʃ3 metals in the IS and AGS samples were significantly higher than US and NS samples (p Cu (465.00) > Zn (427.16) > Cr (34.20) > Cd (19.45) > Ni (7.09); urban region: Zn (97.45) > Cu (79.90) > Pb (64.09) > Cr (5.30) > Ni (2.55) > Cd (1.73); agricultural region: Zn (247.88) > Pb (164.89) > Cu (116.84) > Cr (11.09) > Ni (7.45) > Cd (5.06); and natural fields: Zn (27.43) > Cu (6.34) > Pb (3.18) > Cr (1.94) > Ni (1.18) > Cd (0.83). According to geo-accumulation index (I-geo), the IS, US, and AGS were classified into “highly-extremely polluted”, “unpolluted-moderately polluted” and “highly polluted”, respectively. Similarly, in accordance with the ecological risk index (ERI), the IS and AGS fell into the very high and considerable categories, respectively, while US land uses area was categorized as low risk. Based on the results obtained from the present study, it can be concluded that the sediments of Asalouyeh coasts in the northern part of the Persian Gulf are heavily contaminated with heavy metals, causing serious negative effects on both the human being and environment