P63 marker Expression in Usual Skin Cancers Compared With Non Tumoral Skin Lesions

Abstract

Background: Non-melanoma skin cancers including basal cell carcinoma and squamous cell carcinoma are the most common malignant diseases in human. The aim of this study was to determine the expression of the P63 marker in common skin cancers and non-tumoral skin lesions and compared the difference between them. Materials and Methods: In this cross-sectional study, sampling was performed from the archive of sample blocks from patients admitted in Shahid Mohammadi Hospital during 2010-2011. Sixty samples (including 30 samples of non-tumoral skin lesions and 30 samples including basal cell carcinoma and squamous cell carcinoma) were studied. The evaluation of p63 gene expression was performed using immunohistochemistry method. Student’s T-test and Chi-square test were used for analysis of the data. Results: P63 gene were expressed in 4 cases (13.33 %) of non_tumoral lesions and all tumoral lesions (100%). In tumoral lesions, 5 cases (16.66 %) showed 1+ severity expression, 11 cases (36.66%) 2+severity expression and 14 cases (46.66 %) 3+severity expression. All 4 non-tumoral lesions showed 1+severity expression of P63gene. Conclusion: The results of this study indicated that the frequency and severity of gene expression of P63 could be used for differentiation between basal cell carcinoma and squamous cell carcinoma as well as non-tumoral skin lesions