12 research outputs found
Probing Chemical Space with Alkaloid-Inspired Libraries
- Author
- A Ganesan
- A Verma
- A Wrobleski
- AA Shelat
- AM Boldi
- AM Meyer
- AM Szpilman
- BE Evans
- BM Trost
- BT Smith
- CA Lipinski
- CD Duarte
- D Camp
- DF Veber
- Digamber Rane
- DJ Newman
- E Fenster
- EG Perez
- F Kopp
- F Lovering
- F Lovering
- GL Thomas
- Gurpreet Singh
- H Lachance
- I Paterson
- J Zuegg
- James N. Plampin
- Jeffrey Aubé
- Jenna L. Wang
- JP Nandy
- JT Njardarson
- JW Daly
- K. J. Frankowski
- L Costantino
- L Costantino
- L Xue
- MD Burke
- Michael C. McLeod
- MS Butler
- N Gericke
- P MacLellan
- PA Clemons
- RA Bauer
- RA Pilli
- RA Pilli
- RW DeSimone
- RW Huigens
- S Wetzel
- SM Weinreb
- V Gracias
- Victor W. Day
- WHB Sauer
- X Li
- Y Zeng
- YK Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2014
- Field of study
Screening of small molecule libraries is an important aspect of probe and drug discovery science. Numerous authors have suggested that bioactive natural products are attractive starting points for such libraries, due to their structural complexity and sp3-rich character. Here, we describe the construction of a screening library based on representative members of four families of biologically active alkaloids (Stemonaceae, the structurally related cyclindricine and lepadiformine families, lupin, and Amaryllidaceae). In each case, scaffolds were based on structures of the naturally occurring compounds or a close derivative. Scaffold preparation was pursued following the development of appropriate enabling chemical methods. Diversification provided 686 new compounds suitable for screening. The libraries thus prepared had structural characteristics, including sp3 content, comparable to a basis set of representative natural products and were highly rule-of-five compliant
Probing chemical space with alkaloid-inspired libraries
- Author
- A Ganesan
- A Verma
- A Wrobleski
- AA Shelat
- AM Boldi
- AM Meyer
- AM Szpilman
- BE Evans
- BM Trost
- BT Smith
- CA Lipinski
- CD Duarte
- D Camp
- DF Veber
- Digamber Rane
- DJ Newman
- E Fenster
- EG Perez
- F Kopp
- F Lovering
- F Lovering
- GL Thomas
- Gurpreet Singh
- H Lachance
- I Paterson
- J Zuegg
- James N. Plampin
- Jeffrey Aubé
- Jenna L. Wang
- JP Nandy
- JT Njardarson
- JW Daly
- K. J. Frankowski
- L Costantino
- L Costantino
- L Xue
- MD Burke
- Michael C. McLeod
- MS Butler
- N Gericke
- P MacLellan
- PA Clemons
- RA Bauer
- RA Pilli
- RA Pilli
- RW DeSimone
- RW Huigens
- S Wetzel
- SM Weinreb
- V Gracias
- Victor W. Day
- WHB Sauer
- X Li
- Y Zeng
- YK Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
- Author
- AM Szpilman
- B Bacsa
- C Walsh
- E Bayer
- ED Brown
- F von Nussbaum
- FE Frerman
- GH Joyce
- H Hamamoto
- H Hamamoto
- H Itoh
- H Steen
- IB Seiple
- J Coste
- JC White
- JE Redman
- JMA Blair
- JP Nandy
- KC Nicolaou
- KL Morrison
- KMG O’Connell
- KS Lam
- KS Lam
- LA Carpino
- LA Carpino
- M Kaupp
- M Meldal
- M Murai
- M Santiago
- MF Chellat
- MS Butler
- N Maillard
- P Klán
- PM Wright
- Q Xiao
- R Bentley
- RJT Mikkelsen
- RM Epand
- RM Wilson
- S Friedrich-Bochnitschek
- S Lawrenson
- SE Rossiter
- SL Pedersen
- SL Schreiber
- T Kaji
- VS Fluxá
- WE Lambert
- Z Tynecka
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Synthesis at the molecular frontier
- Author
- A Das
- A Hinman
- A Padwa
- AM Szpilman
- AT Krueger
- Benjamin L. Miller
- BM Trost
- BR McNaughton
- D Chappell
- D Seebach
- DA LaVan
- DA Nicewicz
- DG Kingston
- DJ Newman
- DP Curran
- EA Dubikovskaya
- EJ Corey
- GL Thomas
- H Chen
- HE Johnson
- I Horvath
- I Vilotijevic
- JE Wulff
- JW Cornforth
- KC Nicolaou
- KJ Hale
- LF Tietze
- M Chanon
- M Koshino
- M-K Sun
- MJ Towle
- MS Chen
- N Hampp
- PA Wender
- PA Wender
- PA Wender
- PA Wender
- PA Wender
- PA Wender
- PA Wender
- Paul A. Wender
- PC Gareiss
- PT Corbett
- RA Yoder
- RM Wilson
- S Sudek
- SL Schreiber
- T Hudlicky
- TJ Maimone
- W Reppe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Review of 14 drowning publications based on the Utstein style for drowning
- Author
- A Schmidt
- AH Idris
- AH Idris
- AH Idris
- Ahamed H. Idris
- AJ Donoghue
- Allart M. Venema
- AM Venema
- Anthony R. Absalom
- B Champigneulle
- B Williams
- C Eich
- C Lin
- CS Youn
- D Szpilman
- DS Warner
- E van Beeck
- EM Lence
- EP Hess
- GL Foltin
- HM Bjornsson
- J Sempsrott
- J Tijssen
- JB Webber
- JE Buick
- JJ Bierens
- JK Kieboom
- JL Hunsucker
- Joost J. L. M. Bierens
- JP Orlowski
- L Joanknecht
- L Papa
- L Quan
- M Nitta
- M Wanscher
- NM Eschmann
- O Franek
- P Lunetta
- PD Tourigny
- PF Allan
- PK Suominen
- PS Auerbach
- R Vahatalo
- S Grmec
- SP Choi
- T Kitamura
- T Newton
- UM Schilling
- WJ Ma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dying to help: Fatal bystander rescues in Australian coastal environments
- Author
- A Attard
- A Turgut
- A. Brookes
- AD MĂ©nard
- AD Short
- AD Short
- AE Peden
- AE Peden
- AE Peden
- AM Venema
- Australia RLSS-
- B Barlas
- B Brighton
- B Castelle
- B Matthews
- C Brannstrom
- C Houser
- C McKay
- D Szpilman
- Eveline J. T. Rijksen
- G Masselink
- G. Masselink
- I Arozarena
- IJ Mackie
- J Howland
- J McCool
- J Wilks
- Jasmin C. Lawes
- JH Pearn
- JH Pearn
- JP Orlowski
- K Moran
- K Moran
- K. Moran
- K. Moran
- MT French
- N Cooney
- PA Leggat
- Qiang Zeng
- R Franklin
- RC Franklin
- RC Franklin
- RC Franklin
- Richard C. Franklin
- Robert W. Brander
- RW Brander
- S Avramidis
- S Pidgeon
- Shane Daw
- SLSA
- SM Willcox-Pidgeon
- VA Gensini
- WHO
- WHO
- WHO
- Y Zhu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Potential Ecological Roles of Artemisinin Produced by Artemisia annua L.
- Author
- A Bharati
- A Brockhoff
- A Zibaee
- AE Lenardis
- AK Tripathi
- AM Galal
- AM Szpilman
- BA Halkier
- CM Moore
- CZ Liu
- DA Miller
- DH Janzen
- DL Klayman
- DL Klayman
- EA Brisibe
- EA Kellogg
- EI Newman
- EM Soylu
- EY Chung
- F Emadi
- F Juteau
- F Levesque
- FE Dayan
- FE Dayan
- G Sharma
- GB Williamson
- GF Almeida de
- GH Posner
- HQ Tang
- I Rasooli
- Inderjit
- J Bajsa
- J Keiser
- J Li
- J Lydon
- JC Laughlin
- JCG Galindo
- JFS Ferreira
- JFS Ferreira
- JG Romagni
- JW Wang
- Karina Knudsmark Jessing
- KK Jessing
- KK Jessing
- KM Meepagala
- L Ni
- L Ni
- L Taiz
- LH Stiles
- M Shekari
- ME Maggi
- MI Qureshi
- MR Tellez
- MSR Nair
- Nina Cedergreeen
- NK Srivastava
- NK Tawfiq
- PC Allen
- PJ Rao
- PM O’Neill
- R Kapoor
- R Khosravi
- RC Joshi
- RC Panamanik
- RG Belz
- S Cavar
- S Herrmann
- S Hiradate
- S Krishna
- SM Hasheminia
- SM Palacios
- SO Duke
- SO Duke
- SO Duke
- Stephen O. Duke
- T Efferth
- TE Wallaart
- V Dhingra
- V Dhingra
- X Simonnet
- Y Pollack
- Y Zeng
- YC Wang
- ZH Qian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Accidental hypothermia–an update
- Author
- A Alfonzo
- A Bacher
- A Caen de
- A Claesson
- A Claesson
- A Claesson
- A Dembeck
- A Hughes
- A Koht
- A Kottmann
- A Mattu
- A Owda
- A Piacentini
- A Truhlar
- AA Topjian
- AB Williams
- AC Krismer
- AC Schmidt
- AD Rollstin
- AF Aslam
- AH Kaji
- AH Sepehripour
- AI Jones
- AM Karlsen
- AM Venema
- AS Wolberg
- AW Conn
- AW Zydlewski
- B Champigneulle
- B Dunne
- B Durrer
- B Schwarz
- Beat Walpoth
- BH Walpoth
- BH Walpoth
- BH Walpoth
- BJ Sran
- BS Romlin
- C Eich
- C Eich
- C Koscik
- C Richard
- C Storm
- CD Deakin
- CH Lee
- CL Lim
- CR Wira
- D Brannigan
- D Camboni
- D Maclean
- D Pujara
- D Skarda
- D Souza de
- D Stub
- D Szpilman
- D Szpilman
- D Szpilman
- D Withington
- DF Danzl
- DF Danzl
- DF Danzl
- DJ Waters
- DJA Brown
- DJA Brown
- DN Kyriacou
- Doug Brown
- DR Axelrod
- E Gruber
- E Hardenbergh
- E Kornberger
- E Mark
- E Ruttmann
- EJ Lavonas
- ER Ashwood
- F Doyle
- F Golden
- F Golden
- F Masaki
- FS Golden
- FS Southwick
- FW Moler
- G Corssen
- G Debaty
- G Debaty
- G Loppnow
- G Putzer
- G Putzer
- G Putzer
- G Strapazzon
- G Strapazzon
- G Wollenek
- Gabriel Putzer
- GG Giesbrecht
- GG Giesbrecht
- GG Giesbrecht
- GG Giesbrecht
- GG Giesbrecht
- GG Giesbrecht
- GG Giesbrecht
- GG Giesbrecht
- Giacomo Strapazzon
- GJ Ploeg van der
- GM Eastwood
- Gregor Broessner
- H Brugger
- H Brugger
- H Brugger
- H Brugger
- H Friberg
- H Gassler
- H Rahn
- HE Wang
- Hermann Brugger
- IR Rogers
- J Biem
- J Bierens
- J Fox
- J Hilmo
- J Rivers
- J Shin
- J Turtiainen
- JA Dobson
- JD Whitby
- JG Cohen
- JG Stone
- JJ Bierens
- JJ Osborn
- JK Kieboom
- JM Murkin
- JM Stocks
- JN McCullough
- JP Gillen
- JP Lundgren
- JP Nolan
- JP O’Connor
- JR Bagley
- JR Klein
- JR Laycock
- JR Roosa
- JS Gregory
- JS Hayward
- JW Miller
- JY Lefrant
- K Dyson
- K Jussila
- K Kinoshita
- K Kiridume
- K Lexow
- K Omori
- K Spooner
- K Tazarourte
- K Zafren
- K Zafren
- KA Delaney
- KH Polderman
- KN Hall
- KO Coskun
- KR Sheak
- KR Ward
- L Chhabra
- L Freer
- L Gordon
- L Gordon
- L Lawson
- L Moroder
- L Osborne
- L Pynnonen
- L Quan
- L Quan
- L Rupprecht
- L Wik
- Les Gordon
- LH Ban
- M Brodmann Maeder
- M Farstad
- M Gilbert
- M Laniewicz
- M Meyer
- M Papenhausen
- M Pasquier
- M Pasquier
- M Pasquier
- M Pytte
- M Roser
- M Strohle
- M Thalmann
- M Wanscher
- M Weuster
- M Zasa
- MA Tortorici
- MB Ducharme
- MB Ducharme
- ME Carr Jr
- Michael Holzer
- Michael Wanscher
- MJ Biggart
- MJ Tipton
- MJ Tipton
- MJ Tipton
- ML Mallet
- MM Stecker
- MN Cocchi
- Monika Brodmann Maeder
- MP Broek van den
- N Ito
- N Mongardon
- N Nielsen
- N Sargant
- N Sultan
- NY Chua
- O Henriksson
- O Henriksson
- O Henriksson
- O Kimberger
- O Thomassen
- OB Reite
- P Holmstrom
- P Lundgren
- P Mair
- P Nordberg
- P Paal
- P Paal
- P Paal
- P Suominen
- P Tikusis
- Peter Paal
- PF Iampietro
- PG Claret
- PK Suominen
- PK Suominen
- R Caluwe
- R Koller
- R Meyer
- R Oberhammer
- R Vahatalo
- RG Bolte
- RL Patel
- RS Loomba
- S Anderson
- S Hungerer
- S Komatsu
- S Kosinski
- S Kosinski
- S Lin
- S Maisch
- S Marland
- S Morita
- S Odegaard
- S Parnia
- S Rahman
- S Rubertsson
- SA Niazi
- SC Skaiaa
- SC Vince
- SE McIntosh
- SE McIntosh
- SJ Oliver
- T Camp-Rogers
- T Darocha
- T Darocha
- T Darocha
- T Deslarzes
- T Locher
- T Locher
- T Tveita
- T Willekes
- T Yagi
- TL Vanden Hoek
- TM Larabee
- TM Olasveengen
- TM Olasveengen
- TV McCaffrey
- U Althaus
- U Pietsch
- U Schmidt
- W Buzello
- WI Cranston
- X Xu
- Y Boue
- Y Boue
- Y Boue
- Z Mosayebi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Kreislaufstillstand in besonderen Situationen
- Author
- (UK) RC
- A Anthi
- A Bouchama
- A Bouchama
- A Bouchama
- A Chalkias
- A Claesson
- A Claesson
- A Claesson
- A Conde-Agudelo
- A Dasgupta
- A Dijkman
- A el-Banayosy
- A Forti
- A Galbois
- A Geibel
- A Gonzalez-Perez
- A Hiruta
- A Hunter
- A Kottmann
- A Mattu
- A Muraro
- A Muraro
- A Natale
- A Nishisaki
- A Page-Rodriguez
- A Pottle
- A Romero-Corral
- A Sacchetti
- A Sebe
- A Sheikh
- A Sheikh
- A Torbicki
- A Travers
- A Truhlar
- A Wahba
- A Zeiner
- A. Alfonzo
- A. Truhlář
- AB Channa
- AB Schneir
- AC Bronstein
- AC Krismer
- AC Miller
- AC Rossi
- AD Farmery
- AD Woolf
- AE Abbas
- AH Idris
- AH James
- AI Larsen
- AJ Bleyer
- AJ Handley
- AJ Layon
- AJ Lepere
- AL Gabry
- AL Huerta-Alardin
- AM Brown
- AM Kelly
- AM Venema
- American Heart Association in collaboration with International Liaison Committee on Resuscitation
- AN Flaris
- AP Goodwin
- AP Hall
- AS Lane
- AT Proudfoot
- AV Alfonzo
- AV Alfonzo
- B Bailey
- B Bailey
- B Brenner
- B Carbonne
- B Champigneulle
- B Doepker
- B Gibbison
- B Izci
- B Mahoney
- B McNally
- B Sibai
- B Surawicz
- BA Hulten
- BA Wallis
- BE Benson
- BE Heradstveit
- BE Winkler
- BF Banahan Jr
- BH Negus
- BH Rowe
- BH Walpoth
- BI Sasyniuk
- BJ Browne
- BJ Maron
- BJ Maron
- BJ Maron
- BJ Maron
- BJ Paice
- BK Kleinschmidt-DeMasters
- BL Risavi
- BM Baumann
- BM Clemency
- BM Patten
- BM Sibai
- BR O’Driscoll
- BS Chan
- BW Bottiger
- BW Böttiger
- BZ Horowitz
- C Anandan
- C Beauvoir
- C Bertrand
- C Bomken
- C Bova
- C Cetrullo
- C Deasy
- C Deasy
- C Deasy
- C Eich
- C Georgiou
- C Kill
- C Kleber
- C Koppel
- C Mendonca
- C Moore
- C Page
- C Powell
- C Sandroni
- C Sandroni
- C Schummer
- C Teodorescu
- C Testori
- C Wallmuller
- C Waruiru
- C Wood
- C Zimmer
- C. Lott
- C. Sandroni
- C.D. Deakin
- CA Barton
- CA Camargo Jr
- CBL El-Hamamy E
- CC Burlew
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- CH Lin
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- CK Grissom
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- D Bergum
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- D Stub
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- D Szpilman
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- D Whitcomb
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- D.A. Zideman
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- DA Wampler
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- E Bautista
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- E Gruber
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- E Hazouard
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- H Bohrer
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- H Brugger
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- J Apel
- J Belohlavek
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- J Bierens
- J Boyd
- J Boyd
- J Brown
- J Duflou
- J Ellerton
- J Engdahl
- J Geoghegan
- J Graf
- J Hilmo
- J Hinkelbein
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- J Jovic-Stosic
- J Khanagavi
- J Nanson
- J O’Grady
- J Robinson
- J Soar
- J Soar
- J Soar
- J Soar
- J Sprung
- J Sprung
- J Stoner
- J Zwingmann
- J. Dunning
- J. Soar
- J.J.L.M. Bierens
- J.P. Nolan
- JA Heit
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- JB Holcomb
- JB Holcomb
- JB Holcomb
- JB Mowry
- JC Nunes
- JC Rittenberger
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- JC Wang
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- JD Roderique
- JE Hollander
- JE Smith
- JF Knight
- JF Rhodes
- JG Meechan
- JH Bamber
- JH Mackay
- JH Modell
- JH Park
- JH Wee
- JH Wee
- JJ Bierens
- JJ Boyd
- JJ Henderson
- JJ Osterwalder
- JK Kieboom
- JL Kaplan
- JL Zimmerman
- JM Gao
- JM Gardin
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- JM Neal
- JM Tadie
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- JP Nolan
- JP Nolan
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- JT Niemann
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- JY Lefrant
- K Boyd
- K Cantwell
- K Choo
- K Crewdson
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- K Hashiba
- K Heard
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- K Lexow
- K Maekawa
- K Nielsen
- K Omori
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- K Rahman
- K Wanger
- K Watts
- K Zafren
- K Zafren
- K.-C. Thies
- KA Sporer
- KA Sporer
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- KF Adams
- KF Chung
- KG Harmon
- KI Kim
- KJ Choo
- KJ Davies
- KJ Schwenzer
- KJ Warner
- KK Chen
- KK Hung
- KK Johansen
- KL Machin
- KM Engebretsen
- KM Kew
- KP Cross
- KR Olson
- KY Chen
- L Baghirzada
- L Duley
- L Duley
- L Duley
- L Duley
- L Duley
- L Duley
- L Duley
- L Gordon
- L Gregorakos
- L Lamhaut
- L Lamhaut
- L Meng
- L Ortiz-Munoz
- L Quan
- L Rasmussen
- L Say
- L Sekhavat
- LA Geddes
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- Treatment of benzodiazepine overdose with flumazenil
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Truhlář A, Deakin CD, Soar J, et al. Kreislaufstillstand in besonderen Situationen. Notfall + Rettungsmedizin. 2015;18(8):833-903
Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies
- Author
- A Lemke
- A Nedal
- A Ogita
- Abu-Salah
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- AG Cioffi
- AM Szpilman
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- C Zhang
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- CR Valenzano
- D Cereghetti
- D Kong
- D LĂłpez
- D-G Kim
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