DOES PREOPERATIVE TIBIAL TUBEROSITY – TROCHLEAR GROOVE DISTANCE EFFECT ON POSTOPERATIVE PATELLAR INSTABILITY IN THE PATIENTS WITH KNEE ARTHROPLASTY DUE TO MEDIUM-ADVANCED KNEE OSTEOARTHRITIS?

Objectives: Determining tibial tubercle-trochlear groove distance range as measured before the operation in the patients to whom total knee prosthesis will be applied due to mid to advanced level of osteoarthritic and seeing the post-operative variations in tibial tubercle-trochlear groove distance and evaluating whether it has any impact on the patellofemoral instability that might develop after the operation.46 knees planned to be applied total knee prosthesis due to mid-advanced level of osteoarthritic were examined. Methods: In the preoperative and postoperative magnetic resonance images MRI routinely taken, tibial tubercle-trochlear groove distance was measured. Later it was examined whether there was correlation between these preoperative and postoperative tibial tubercle-trochlear groove measurements and the data recorded before operation. Results: Preoperative tibial tubercle-trochlear groove distance was found to be 8.83±3.54, postoperative tibial tubercle-trochlear groovedistance was found to be 8.30±3.89 and preoperative-postoperative tibial tubercle-trochlear groove variation was found to be 0,52±3,64 (p=0,337). In the patients whose alignment was 10 degrees or less, Pre-Op tibial tubercle-trochlear groove distance was measured as 8.74±3.18 and in the patients whose alignment was more than 10 degrees, it was measured as 8.89±3,83 ( p=0.888). In the patients whose alignment was 10 degrees or less, Post-Op tibial tubercle-trochlear groove distance was measured as 8.00±2.85 and in the patients whose alignment was more than 10 degrees, it was measured as 8.52±4.52 (p=0.661). In the patients whose alignment was 10 degrees or less, tibial tubercle-trochlear groove distance variation was measured as 0.74± 3.25 and in the patients whose alignment was more than 10 degrees, it was measured as 0.37± 3.95 (p=0.741). Conclusion: As a result, although tibial tubercle-trochlear groove distance was observed with a great variation in the osteoarthritic knees at stage 3-4, it was nonetheless measured within normal limits and Post-Op variation was not meaningful. Since this is the first study in the literature on the measurement of tibial tubercle-trochlear groove distance in the total knee prosthesis applications, we hope that it would shed some light on similar studies to be conducted in the future

Effects of Aminoguanidine on Glomerular Basement Membrane Thickness and Anionic Charge in a Diabetic Rat Model

We investigated the effect of aminoguanidine (AG) administration on GBM thickness, glomerular heparan sulfate (HS) content, and urinary albumin and HS excretion in diabetic rats. After induction of diabetes, female Wistar rats were divided into 2 groups: Group AGDM (n=11) received 1g/L aminoguanidine bicarbonate in drinking water, group DC (n=12) was given only tap water. Control rats received AG (group AGH, n=8) or tap water (group HC, n=8). At the end of a period of 8 weeks, urinary albumin and glycosaminoglycan (GAG) excretion was detected. GBM heparan sulfate distribution and count was determined under the electron microscope. The AGDM group had lower urinary albumin and GAG excretion than diabetic controls. GBM thickness was increased in diabetic rats compared to groups of AGDM and HC. In AGDM group alcian blue stained particle distribution and count in the GBM was similar to healthy controls. In conclusion AG prevents the decrease of anionic charged molecules in the GBM and GBM thickening. This can be one of the mechanisms by which AG decreases albuminuria in diabetic rats

ZOLEDRONIC ACID ADMINISTRATION ENHANCES FRACTURE HEALING IN THE OSTEOPOROTIC FRACTURES IN OVARIECTOMIZED RABBITS

Objectives: To evaluate the radiological, histological and mechanical effects on osteoporotic fracture healing of single-dose zoledronic acid (ZA) applied to an animal model with an experimentally created osteoporotic bone fracture. Methods: A total of 14 adult, female New Zealand rabbits, aged 5-6 months were used in the study. Bone mineral density (BMD) values were calculated from bone densitometry measurements and recorded. Bilateral ovariectomy was then applied to all the rabbits. At 10 weeks after ovariectomy, bone densitometry was again performed on all the animals and the BMD values were compared. Osteoporosis was accepted as having developed in animals determined with a reduction of 28% in BMD values. After the placement of a K-wire intramedullarly in the femurs of the rabbits, a closed fracture was created with the standard method. The animals were then randomly separated into 2 groups as the zoledronic acid group (ZAG) and the control group (CG). An infusion of 0.1mg/kg ZA was administered to the ZAG animals from the ear vein. With visualisation of bone union rabbits were sacrificed by decapitation. Radiological, mechanical and histological assesments were then applied. Results: In the histological evaluation, the mean histological score was determined as 5.00 in the ZAG and 3.00 in the CG. The difference between the groups was found to be statistically significant (p<0.001). In the radiological evaluation, the mean score was 7.00 in the ZAG and 6.25 in the CG. Even though higher points were obtained by the ZAG in the inter-observer evaluations, the difference between the groups was not statistically significant (p=0.073). In the mechanical evaluation, the elasticity collapse in negative proportion to rigidity was measured as 2.91 mm in the ZAG and 3.96mm in the CG (p=0.686). The rigidity data of the ZAG were higher in the mechanical tests but the difference between the groups was not statistically significant (p=0.086). Conclusion: As the results of the study showed that the ZAG had higher values than those of the CG in all the histological, mechanical and radiological evaluations, the application of a single dose of ZA can be considered to increase the healing of osteoporotic fractures