Combined therapies of antithrombotics and antioxidants delay in silico brain tumor progression

Glioblastoma multiforme, the most frequent type of primary brain tumor, is a rapidly evolving and spatially heterogeneous high-grade astrocytoma that presents areas of necrosis, hypercellularity and microvascular hyperplasia. The aberrant vasculature leads to hypoxic areas and results in an increase of the oxidative stress selecting for more invasive tumor cell phenotypes. In our study we assay in silico different therapeutic approaches which combine antithrombotics, antioxidants and standard radiotherapy. To do so, we have developed a biocomputational model of glioblastoma multiforme that incorporates the spatio-temporal interplay among two glioma cell phenotypes corresponding to oxygenated and hypoxic cells, a necrotic core and the local vasculature whose response evolves with tumor progression. Our numerical simulations predict that suitable combinations of antithrombotics and antioxidants may diminish, in a synergetic way, oxidative stress and the subsequent hypoxic response. This novel therapeutical strategy, with potentially low or no toxicity, might reduce tumor invasion and further sensitize glioblastoma multiforme to conventional radiotherapy or other cytotoxic agents, hopefully increasing median patient overall survival time.Comment: 8 figure

A novel distributed architecture for IoT image processing using low-cost devices and open internet standards

Industry 4.0 can be defined as the integration of computers and automation to current industrial processes, with addition of smart and autonomous systems leveraged by machine learning techniques. In this scenario, a compact, dependable and fast controller is desired, featuring low energy consumption, easily programming and maintenance, with no mobile parts. Nowadays, computing power in single board computers, e.g. the Raspberry Pi among others, has been increased at a very important rate. In just three generations, Pi computers offer almost a two-fold speed gain, when compared to first models. Its design, an underlying video driver with general capabilities of regular OSes, makes them quite suitable to build image processing systems at very low cost, with no mobile parts and low energy consumption. However, designing such a system for industrial image processing is a tough challenge, since it implies to integrate cameras, image processing libraries, database servers and application software with graphical user interface, in an already resource constrained device. This work presents a new architecture for this kind of systems, by means of open internet standards, using a self-contained, high performance web server to publish a RESTful API and a set of web pages that use latest HTML5 capabilities to manage USB webcams and system data. This proposal also integrates OpenCV as a compiled script on client-side using the new WASM paradigm, with an optimized storage for images using -industry-standard RDBMS and a modular design that can target Windows and Linux as well.Sociedad Argentina de Informática e Investigación Operativ

Estimating contact rates between Metarhizium anisopliae–exposed males with female Aedes aegypti

Introduction: Effective control of Aedes aegypti will reduce the frequency and severity of outbreaks of dengue, chikungunya, and Zika; however, control programs are increasingly threatened by the rapid development of insecticide resistance. Thus, there is an urgent need for novel vector control tools, such as auto-dissemination of the entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana. The aim of this study was to estimate contact rates of M. anisopliae-exposed males with wild female Ae. aegypti. As a control the contact rates of untreated males with wild females was contrasted. Methods: The study was conducted in Reynosa, Mexico. The treatment and control households (n = 15 per group) were geographically separated by an arid and hot area that naturally prevented the flight of males between arms. In each control household, 40 M. anisopliae-exposed male Ae. aegypti were released per week for 8 weeks (specimens were exposed to a concentration of 5.96 × 107 conidia/cm2 for 24 h; n = 4,800 males). In each control household, 40 untreated males were released per week for 8 weeks (n = 4,800 males). All specimens were dust-marked prior to release. Mosquito abundance was monitored with human landing collections, and captured Ae. aegypti were examined for any dust-marking. Results: In the treatment households, the contact rate of Ae. aegypti females with marked, fungus-treated males was 14% (n = 29 females marked from 197). Where in the control households, the contact rate of females with marked, untreated males was only 6% (n = 22 marked from 365). In the treatment households the recapture rate of released males was at 5% and higher than that for the control households (which was 2%). Auto-dissemination of M. anisopliae from infected males to female Ae. aegypti was demonstrated through the recovery of an infected female from the floor of a household. Conclusions: Overall, the contact rate between M. anisopliae-infected males with the natural female population was 60% higher than for the control group of healthy males. The results provide further support to the release of fungus-exposed males as a potentially useful strategy against Ae. aegypti, though further research is required

CloudBench: an integrated evaluation of VM placement algorithms in clouds

A complex and important task in the cloud resource management is the efficient allocation of virtual machines (VMs), or containers, in physical machines (PMs). The evaluation of VM placement techniques in real-world clouds can be tedious, complex and time-consuming. This situation has motivated an increasing use of cloud simulators that facilitate this type of evaluations. However, most of the reported VM placement techniques based on simulations have been evaluated taking into account one specific cloud resource (e.g., CPU), whereas values often unrealistic are assumed for other resources (e.g., RAM, awaiting times, application workloads, etc.). This situation generates uncertainty, discouraging their implementations in real-world clouds. This paper introduces CloudBench, a methodology to facilitate the evaluation and deployment of VM placement strategies in private clouds. CloudBench considers the integration of a cloud simulator with a real-world private cloud. Two main tools were developed to support this methodology, a specialized multi-resource cloud simulator (CloudBalanSim), which is in charge of evaluating VM placement techniques, and a distributed resource manager (Balancer), which deploys and tests in a real-world private cloud the best VM placement configurations that satisfied user requirements defined in the simulator. Both tools generate feedback information, from the evaluation scenarios and their obtained results, which is used as a learning asset to carry out intelligent and faster evaluations. The experiments implemented with the CloudBench methodology showed encouraging results as a new strategy to evaluate and deploy VM placement algorithms in the cloud.This work was partially funded by the Spanish Ministry of Economy, Industry and Competitiveness under the Grant TIN2016-79637-P “Towards Unifcation of HPC and Big Data Paradigms” and by the Mexican Council of Science and Technology (CONACYT) through a Ph.D. Grant (No. 212677)

A P-Lingua based simulator for tissue P systems

AbstractInvestigations within the field of tissue-like P systems are being conducted, on one hand studying their computational efficiency, and on the other hand exploring the possibilities to use them as a computational modelling framework to biological phenomena.In both cases it is necessary to develop software that provides simulation tools (simulators) for the existing variety of tissue P systems. Such simulators allow us to carry on computations of solutions to computationally hard problems on certain (small) instances. Moreover, they also provide a way to verify tissue-like models for real biological processes, by means of experimental data.The paper presents an extension of P-Lingua (a specification language intended to become a standard for software devoted to P systems), in order to cover the class of tissue-like P systems, that were not considered in the previous release. This extension involves on one hand defining the syntax to be used, and on the other hand introducing a new built-in simulation algorithm that has been added to the core library of P-Lingua

Towards a Programming Language in Cellular Computing

AbstractSeveral solutions to hard numerical problems using P systems have been presented recently, and strong similarities in their designs have been noticed. In this paper we present a new solution, to the Partition problem, via a family of deterministic P systems with active membranes using 2-division. Then, we intend to show that the idea of a cellular programming language is possible (at least for some relevant family of NP-complete problems), indicating some “subroutines” that can be used in a variety of situations and therefore could be useful for designing solutions for new problems in the future

Congenital anomalies of the optic nerve

AbstractCongenital optic nerve head anomalies are a group of structural malformations of the optic nerve head and surrounding tissues, which may cause congenital visual impairment and blindness. Each entity in this group of optic nerve anomalies has individually become more prevalent as our ability to differentiate between them has improved due to better characterization of cases. Access to better medical technology (e.g., neuroimaging and genetic analysis advances in recent years) has helped to expand our knowledge of these abnormalities. However, visual impairment may not be the only problem in these patients, some of these entities will be related to ophthalmologic, neurologic and systemic features that will help the physician to identify and predict possible outcomes in these patients, which sometimes may be life-threatening. Herein we present helpful hints, associations and management (when plausible) for them