Three water sites in upper mantle olivine and the role of titanium in the water weakening mechanism

Infrared spectroscopy on synthetic olivines has established that there are at least four different mechanisms by which hydrogen is incorporated into the crystal structure. Two mechanisms occur in the system MgO-SiO2-H2O associated with silicon and magnesium vacancies, respectively. A third mechanism is associated with trivalent cation substitution, commonly Fe3+ in natural olivine, while the fourth mechanism, which is the one most prevalent in natural olivines from the spinel-peridotite facies of the Earth’s upper mantle, is associated with Ti4+ [Berry et al., 2005]. Here first principles calculations based on density functional theory are used to derive the structure and relative energies of the two defects in the pure MgO-SiO2-H2O system, and possible hydrogen-bearing and hydrogen-free point defects in Ti4+-doped forsterite. Calculated structures are used to compare the predicted orientation of the O-H bonds with the experimentally determined polarization. The energies are used to discuss how different regimes of chemical environment, temperature (T), pressure (P), and both water content and water fugacity ( fH2O), impact on which of the different hydroxyl substitution mechanisms are thermodynamically stable. We find that given the presence of Ti impurities, the most stable mechanism involves the formation of silicon vacancies containing two protons charge balanced by a Ti4+ cation occupying an adjacent octahedral site. This mechanism leads to the water-mediated formation of silicon vacancies. As silicon is known to be the most slowly diffusing species in olivine, this provides a credible explanation of the observed water weakening effect in olivine

Towards an expanded model of litigation

Introduction: The call for contributions for this workshop describes the important new challenges for the legal search community this domain brings. Rather than just understanding the challenges this domain poses in terms of their technical properties, we would like to suggest that understanding these challenges as socio-technical challenges will be important. That is, as well as calling for research on a technical level to address these challenges we are also calling for work to understand the social practices of those involved in e-discovery (ED) and related legal work. A particularly interesting feature of this field is that it is likely that search technologies will (at least semi-)automate responsiveness review in the relatively near term and this will change the way that the work is organised and done in many ways – offering new possibilities for new ways of organising the work. As well as designing those technologies for automating responsiveness review we need to be envisioning how the work will be done in the future, how these technologies will impact the organisation of the case and so on. In this position paper we therefore outline the importance of understanding the wider social context of ED when designing tools and technologies to support and change the work. We would like to reinforce and expand on Conrad’s call for IR researchers to understand just what ED entails [2], include the stages that come both before and after core retrieval activities. The importance of considering the social aspects of work in the design of the technology has been established for some time. Ushering in this ‘turn to the social,’ and focusing on interface design, Gentner and Grudin [4] described how the GUI has already changed from an interface for engineers, representing the engineering model of the machine to one that supported single ‘everyman’ users (based on ideas from psychology). From then onwards the interface has evolved to support groups of users, taking into account the social and organisational contexts of use. This has particular resonance for the design of ED technologies: during ED in particular and the wider legal process there are often many lawyers involved – reviewing documents, determining issues, etc. Even if the way that their work is organised currently is not seen as collaborative in the traditional sense – with individual lawyers working on individual document sets to review them - their work needs to be coordinated and it seems likely that their work could be enhanced by, for example, knowledge of what their colleagues had found, how the case was shaping up, new key terms and facts turned up and so on. Work is often modelled for the purposes of design using process models, but this misses out on the richness and variety actually found when one examines how the work is carried out [3]. Technologies which strictly enforce the process models can often hinder the work, or end up being worked around as was the case with workflow systems since people interpret processes very flexibly to get the work done ([1], [3]). Other studies in other fields have found similar problems when systems are designed on for example cognitive models of how the work is done; they often do not take into account the situated nature of the work and thus they can be very difficult to use [5]. We believe, like [2], that a clear understanding of the social practices of ED is vital for the creation of high-quality, meaningful tools and technologies. We furthermore propose that work practice studies, to be used in combination with other methods, are a central part of getting the detailed understanding of the work practices central to designing useful and intelligent tools. Work practice studies would involve ethnographies, consisting primarily of observation, undertaken of practitioners engaging in the work of ED

Organ failure, outcomes and deprivation status among critically ill cirrhosis patients — a one-year cohort study

No abstract available

Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent

Objectives: Tert-butyl benzoquinone (TBBQ) is the oxidation product of tert-butyl hydroquinone (TBHQ), an antimicrobial food additive with >40 years of safe use. TBBQ displays potent activity against Staphylococcus aureus biofilms in vitro. Here, we report on studies to further explore the action of TBBQ on staphylococcal biofilms, and provide a preliminary preclinical assessment of its potential for use as a topical treatment for staphylococcal infections involving a biofilm component. Methods: The antibacterial properties of TBBQ were assessed against staphylococci growing in planktonic culture and as biofilms in the Calgary Biofilm Device. Established assays were employed to measure the effects of TBBQ on biofilm structure and bacterial membranes, and to assess resistance potential. A living skin equivalent was used to evaluate the effects of TBBQ on human skin. Results: TBBQ eradicated biofilms of S. aureus and other staphylococcal species at concentrations ≤64 mg/L. In contrast to other redox-active agents exhibiting activity against biofilms, TBBQ did not cause substantial destructuring of the biofilm matrix; instead, the antibiofilm activity of the compound was attributed to its ability to kill slow- and non-growing cells via membrane perturbation. TBBQ acted synergistically with gentamicin, did not damage a living skin equivalent following topical application, and exhibited low resistance potential. Conclusions: The ability of TBBQ to eradicate biofilms appears to result from its ability to kill bacteria regardless of growth state. Preliminary evaluation suggests that TBBQ represents a promising candidate for development as a topical antistaphylococcal biofilm agent

Las especies amenazadas son indicadoras de los puntos calientes de la regulación trófica en sentido descendente

Se ha considerado la introducción de mesopredadores y herbívoros extranjeros como el principal desencadenante de la extinción de mamíferos australianos. Estudios recientes sugieren que los efectos devastadores de las especies invasoras quedan mitigados por los superpredadores. Por lo tanto, la supervivencia de muchas especies amenazadas puede depender de la presencia y funcionalidad ecológica de los grandes predadores. El superpredador australiano, el dingo (Canis lupus dingo) ha sido muy perseguido por todo el continente, y es extremadamente raro encontrar poblaciones de dingos que no estén sujetas a un control letal. En este estudio pronosticamos que la presencia de especies amenazadas señala los lugares donde las poblaciones de dingos están relativamente intactas, y que su ausencia puede indicar que los dingos son raros o que sus poblaciones están socialmente fracturadas. La comparación entre un lugar que alberga a un marsupial amenazado, el kowari o rata marsupial de cola de pincel (Dasyuroides byrnei), y un lugar vecino, de donde falta el kowari, es concordante con el patrón que sugerimos. Palabras clave: Envenenamiento con 1080, Canis lupus dingo, Dasyuroides byrnei, Especie invasora, Control por predador, Superpredador.The introduction of alien mesopredators and herbivores has been implicated as the main driver of mammalian extinction in Australia. Recent studies suggest that the devastating effects of invasive species are mitigated by top–order predators. The survival of many threatened species may therefore depend on the presence and ecological functioning of large predators. Australia’s top predator, the dingo (Canis lupus dingo), has been intensively persecuted across the continent and it is extremely rare to find dingo populations that are not being subjected to lethal control. We predicted that the presence of threatened species point out places where dingo populations are relatively intact, and that their absence may indicate that dingoes are either rare or socially fractured. A comparison of a site which harbors a threatened marsupial, the kowari (Dasyuroides byrnei), and a neighboring site where the kowari is absent, offers support for this suggested pattern. Key words: 1080 poison–baiting, Canis lupus dingo, Dasyuroides byrnei, Invasive species, Predator control, Top predator.Se ha considerado la introducción de mesopredadores y herbívoros extranjeros como el principal desencadenante de la extinción de mamíferos australianos. Estudios recientes sugieren que los efectos devastadores de las especies invasoras quedan mitigados por los superpredadores. Por lo tanto, la supervivencia de muchas especies amenazadas puede depender de la presencia y funcionalidad ecológica de los grandes predadores. El superpredador australiano, el dingo (Canis lupus dingo) ha sido muy perseguido por todo el continente, y es extremadamente raro encontrar poblaciones de dingos que no estén sujetas a un control letal. En este estudio pronosticamos que la presencia de especies amenazadas señala los lugares donde las poblaciones de dingos están relativamente intactas, y que su ausencia puede indicar que los dingos son raros o que sus poblaciones están socialmente fracturadas. La comparación entre un lugar que alberga a un marsupial amenazado, el kowari o rata marsupial de cola de pincel (Dasyuroides byrnei), y un lugar vecino, de donde falta el kowari, es concordante con el patrón que sugerimos. Palabras clave: Envenenamiento con 1080, Canis lupus dingo, Dasyuroides byrnei, Especie invasora, Control por predador, Superpredador

Threatened species indicate hot-spots of top-down regulation

The introduction of alien mesopredators and herbivores has been implicated as the main driver of mammalian extinction in Australia. Recent studies suggest that the devastating effects of invasive species are mitigated by top-order predators. The survival of many threatened species may therefore depend on the presence and ecological functioning of large predators. Australia’s top predator, the dingo (Canis lupus dingo), has been intensively persecuted across the continent and it is extremely rare to find dingo populations that are not being subjected to lethal control. We predicted that the presence of threatened species point out places where dingo populations are relatively intact, and that their absence may indicate that dingoes are either rare or socially fractured. A comparison of a site which harbors a threatened marsupial, the kowari (Dasyuroides byrnei), and a neighboring site where the kowari is absent, offers support for this suggested pattern

Necrosis of a Guinea Pig Stomach after Contact with Povidone-Iodine: a Case Report

Rodents are the most frequently used animals in surgical experimentation. It is estimated that guinea pigs in particular are the third most commonly used species in this context. To disinfect guinea pigs’ skin, either alcohol or surgical iodine are most often used. In the context of an animal research project, a Nissen operation was performed in an adult male guinea pig. Because of accidental contamination of the operative field, a 10% povidone-iodine cutaneous solution was applied to the serosa of the anterior wall of the stomach and to the gastric fundus. The guinea pig died 12 hours after surgery due to an acute necrotizing hemorrhagic gastritis. Although there have been a few reports of povidone-iodine toxicity in the guinea pig, as far as the authors could determine, this is the first time that such a serious abdominal complication is reported. The authors believe that the possibility of a similar event should be taken into consideration when planning, executing and interpreting experiments in the guinea pig

Active cloaking of finite defects for flexural waves in elastic plates

We present a new method to create an active cloak for a rigid inclusion in a thin plate, and analyse flexural waves within such a plate governed by the Kirchhoff plate equation. We consider scattering of both a plane wave and a cylindrical wave by a single clamped inclusion of circular shape. In order to cloak the inclusion, we place control sources at small distances from the scatterer and choose their intensities to eliminate propagating orders of the scattered wave, thus reconstructing the respective incident wave. We then vary the number and position of the control sources to obtain the most effective configuration for cloaking the circular inclusion. Finally, we successfully cloak an arbitrarily shaped scatterer in a thin plate by deriving a semi-analytical, asymptotic algorithm.Comment: 19 pages, 14 figures, 1 tabl