Some aspects of hemodynamic disorders in patients with severe withdrawal syndrome

Arterial hypertension - the most common cardiovascular syndrome in many countries of the world. Up to 40-50% of the adult population of economically developed countries has an arterial pressure in excess of 140/90 mm Hg. Art. The author discusses the results of research conducted in 2010 -2012 inthe department of resuscitation and intensive care of theChernivtsiRegionalPsychiatric Hospital. 40 patients were examined: Group 1 - 20 patients diagnosed with withdrawal due to delirium alcohol. The results indicate significant hemodynamic disturbances in patients with withdrawal due to the use of delirium alcohol and patients with threatened delirium during hospitalization

Теоретические основы медицинской реабилитации = Theoretical foundations of medical rehabilitation

Gozhenko E A, Badyin I Yu, Gozhenko A I. Теоретические основы медицинской реабилитации = Theoretical foundations of medical rehabilitation. Journal of Education, Health and Sport. 2015;5(5):213-224. ISSN 2391-8306. DOI 10.5281/zenodo.17591http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%285%29%3A213-224https://pbn.nauka.gov.pl/works/559820http://dx.doi.org/10.5281/zenodo.17591Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja.Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 15.02.2015. Revised 27.04.2015. Accepted: 08.05.2015. Теоретические основы медицинской реабилитацииTheoretical Foundations of Medical Rehabilitation Е. А. Гоженко, И. Ю. Бадьин, А. И. Гоженко E A Gozhenko, I Yu Badyin, A I Gozhenko  Украинский НИИ медицины транспорта, ОдессаUkrainian Research Institute for Medicine of Transport, Odessa AbstractIn modern medicine, medical rehabilitation technology successfully developed and are an integral part of the effectiveness of the treatment of most diseases. The main objective in this case is to restore the structural and functional organization of organs and tissues to restore directed by discount disease functionality of an organism. It should be emphasized that the stimulation of the pathology of the compensation of disturbed functions in rehabilitation of existing technologies is always based on the inclusion of urgent adaptation mechanisms by increasing the intensity of functioning structures which, through subsequent actions (processes) are activated processes of hypertrophy and regeneration to ensure an increase in the number of functioning structures the basis of morphological changes are the basis of long-term mechanisms of adaptation / compensation, which are the basis of clinical adaptation. One of the promising methods of adaptation can be external bioprogramming. Keywords: medical rehabilitation, external bioprogramming, adaptation. В современной медицине технологии медицинской реабилитации успешно разрабатываются и являются неотъемлемой частью эффективности лечения большинства заболеваний. Основной задачей при этом является восстановление структурно-функциональной организации органов и тканей неправленое на восстановление сниженных при болезни функциональных возможностей организма. Стимуляция процессов компенсации нарушенных при патологии функций в существующих реабилитационных технологиях всегда основана на включении срочных механизмов адаптации за счет увеличения интенсивности функционирующих структур, которые посредством последующих воздействий (процессов) активируют процессы гипертрофии и регенерации обеспечивающих увеличению количества функционирующих структур на основе морфологических изменений, являющих базой долговременных механизмов адаптации/компенсации, которые являются основой клинической адаптации. Одним из перспективных методов адаптации может быть внешнее биопрограммирование. Ключевые слова: медицинская реабилитация, внешнее биопрограммирование, адаптация

Morphological changes in the kidneys of rats with experimental hemorrhagic stroke (intracerebral hemorrhage)

The article presents the results of the study of morphological changes in the kidneys in Wistar rats during the stroke. Hemorrhagic stroke modeling was performed by injecting 0.1-0.2 ml of autoblood through an opening in the temporal bone into the region of the inner capsule of the right hemisphere. To form a hematoma, a stereotaxic destruction was performed. The experimental group consisted of 6 animals, the control group was represented by intact rats (n=3) and rats after trepanation of the temporal bone but without the introduction of autoblood (n=3). The animals were removed from the experiment on days 3 and21. Inthe course of the study, the structural changes in the right and left kidneys were compared to determine the difference in the location of the disorders. According to the results of the histological examination of the medulla, the tendency to reduction of cytological disorders of the epithelium of the tubules of the left kidney was revealed, while in the right kidney the structural disturbances of the tubules of the nephrons and the collecting ducts of the papilla of the kidney were recorded. Based on these data, it is possible to assume renal involvement in rats on day 3 after a stroke and a frequency recovery on day 21. The described histological studies give  a new data on the development of structural changes in renal medulla in rats with hemorrhagic stroke, which can be associated with a violation of electrolyte exchanges at the level of the distal nephron segment

Analysis of heart rate variability in patients with chronic alcohol abuse

Article represents the results of studies on the use of the method of assessment of heart rate variability in patients with alcohol withdrawal syndrome without delirious syndrome and in patients with the condition as a result of alcohol withdrawal with delirium tremens in the intensive care unit. The studies were conducted on the first day of hospitalization in both groups of patients in the clinic. These data were compared with the norms of the corresponding options of heart rate variability and among themselves. The results indicate a significant autonomic dysfunction in patients with chronic alcohol dependence. The study determined the correlation between heart rate variability and hemodynamics in both groups

Prevention of colitis in rats receiving palm oil on the background of dysbiosis by using quertulin

Aim: Identify the possibility of preventing colitis that develops in rats when consuming palm oil against dysbiosis. Materials and Methods: Antidysbiosis agent "Quertulin" (Quercetin + Inulin + Citrate Ca) was used. Biological experiments were performed on rats receiving a non-fat diet (NFD). The second group of rats received a diet in which 15% of starch was replaced with 15% palm oil containing 42% palmitic acid (C16:0). The third group of rats received a diet of palm oil and, in addition, received quertulin 400 mg / kg daily for 38 days. Rats of the 2nd and 3rd groups for development of dysbiosis from the first day of the experiment received lincomycin (60 mg / kg) with drinking water for 5 days. The activity of elastase, catalase, urease, lysozyme and the content of malodialdehyde (MDA) was determined in the gut mucosal homogenates. The ratio of catalase and MDA was calculated by the antioxidant-prooxidant index of API, according to the ratio of relative activity of urease and lysozyme – the degree of dysbiosis. Results: In rats receiving palm oil on the background of dysbiosis, the activity of elastase, urease, MDA content and the degree of dysbiosis increases in the mucosa of the colon, but the activity of catalase, lysozyme, and index API decreases. In rats receiving quertulin, the level of elastase, MDA, catalase, urease and lysozyme normalized, the API index increased and the degree of dysbiosis decreased. Conclusions: Consumption of palm oil on the background of dysbiosis causes the development of colitis and dysbiosis by reducing the level of nonspecific immunity and antioxidant protection. Antidysbiotic mean Quertulin has mucosoprotective action

Interpersonal differences between of the entropies of EEG, HRV, immunocytogram and leukocytogram

Background. Previously, we have shown that in humans entropy of the normalized parameters of the HRV and SPD of loci of EEG significantly correlate with the entropy of Leukocytogram and Immunocytogram as well as parameters of immunity, which testifies to their modulating regulatory effects. This article is a direct extension of the previous one. Its purpose is the distribution of the observed contingent into groups that are homogeneous in terms of entropy of the HRV, EEG as well as Leukocytogram and Immunocytogram. Material and methods. In basal conditions in 37 men and 14 women with chronic pyelonephritis and cholecystitis in remission as well as without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood we determined relative content of components (RCC) of Immunocytogram (ICG) (T helper, T cytolytic, B and NK lymphocytes) and Leukocytogram (LCG) (Eosinophils, Stub and Segmentonucleary Neutrophils, Lymphocytes and Monocytes). Than we calculated for each locus of EEG and HRV as well as for ICG and LCG the Entropy (h) of normalized spectral power density (SPD) or RCC using Shannon’s formula. Results. The method of cluster analysis is revealed that in members of the major cluster (60%), the entropy of EEG, HRV, ICG and LCG varies within the normal range (-0,5σ ÷ +0,5σ). The members of the next largest cluster (23%) are characterized by a moderately increased entropy of the SPD of EEG in conjunction with the normal entropy of the ICG and the moderately reduced entropy of HRV and LCG. The members of the third cluster (9%) noted a significantly lower entropy (negentropy) of the SPD in loci F3, F4, T3 and C4; in addition, there is a moderate decrease in the entropy of the LCG. Instead, members of the last cluster (8) noted the negentropy of SPD in paired loci Fp1 and Fp2, T5 and T6, T3 and T4, F7 and F8 as well as O1 and O2; in addition, there is a moderate decrease in entropy of the ICG. The entropy of other EEG locus as well as of HRV and LCG is within the normal range. Conclusion. The enropy of HRV and SPD of loci of EEG as well as ICG and LCG is characterized by a large variation, which corresponds to the known wide variance of parameters of the ICG and LCG, which are subordinate to the regulatory influences of the central and autonomic nervous system

Stages of development of streptozotocin-induced experimental diabetes mellitus

The article presents data about the stages of experimental diabetes mellitus under conditions of the streptozotocin administration. It is noted that in the early development of experimental diabetes, changes in the kidneys proceeds in three stages: physiological adaptation; increasing morphological and functional changes and maladaptation; pathophysiological stage. The data related to changes in glomerular filtration rate, acid excretion, individual morphological alterations, etc. are given. The indicated changes in the opinion of the authors indicate an adaptive reaction of the system of regulation of water-salt metabolism and its main effector organ - the kidneys - to hyperosmia, caused by hyperglycemia with the subsequent formation of diabetic nephropathy

Relationships between the entropies of EEG, HRV, immunocytogram and leukocytogram

Background. In mathematics the entropy is a measure of uncertainty of a random function; in the theory of information entropy is a measure of uncertainty in a situation, any experience (test) that can have different consequences. The entropy is also a measure of disorder, the degree of chaos present in the system. CE Shannon linked the mathematical dependence of the concept of information and entropy, which characterizes the degree of ordering of the system. This estimate of the amount of information coincides with the estimation of the quantitative measure of elimination of uncertainty of entropy, the degree of organization of the system. It is well known about functional interactions between central and autonomic nervous and immune systems. In the context of this concept, we have prioritized research on the interconnections between the entropies of these systems. Material and methods. In basal conditions in 37 men and 14 women with chronic pyelonephritis and cholecystitis in remission as well as without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood we determined relative content of components (RCC) of Immunocytogram (ICG) (T helper, T cytolytic, B and NK lymphocytes) and Leukocytogram (LCG) (Eosinophils, Stub and Segmentonucleary Neutrophils, Lymphocytes and Monocytes). Than we calculated for each locus of EEG and HRV as well as for ICG and LCG the Entropy (h) of normalized spectral power density (SPD) or RCC using Shannon’s formula: Results. There was a complete absence of correlation between hHRV and hLCG (r=-0,03) as well as hICG (r=-0,03), whereas the relationship between hLCG and hICG is significant (r=-0,40; p<0,001). Accepting the entropy of EEG HRV as a factor, using the correlation analysis with step-by-step exclusion, we obtain the equations for dependent variables. Canonical correlation between hHRV&EEG, on the one hand, and hLCG&Immunity, on the other hand, is strong: R=0,814; R2=0,663; χ2(240)=296; p=0,008. Conclusion. The enropy of HRV and EEG significantly correlate with the entropy and parameters of immunity, which testifies to their modulating regulatory effects

Роль полиморфизма A1470T гена MCT1 в развитии выносливости и скорости у спортсменов = The role of A1470T gene polymorphism MCT1 in development speed and endurance in athletes

Kozyrev A. V. Gozhenko A. I., Sikora K., Zukow W. Роль полиморфизма A1470T гена MCT1 в развитии выносливости и скорости у спортсменов = The role of A1470T gene polymorphism MCT1 in development speed and endurance in athletes. Journal of Education, Health and Sport. 2016;6(10):253-262. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.161067http://ojs.ukw.edu.pl/index.php/johs/article/view/3938   The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 02.10.2016. Revised 02.10.2016. Accepted: 15.10.2016.   РОЛЬ ПОЛИМОРФИЗМА A1470T ГЕНА MCT1 В РАЗВИТИИ ВЫНОСЛИВОСТИ И СКОРОСТИ У СПОРТСМЕНОВThe role of A1470T gene polymorphism MCT1 in development speed and endurance in athletes Kozyrev A. V. Gozhenko A. I., Sikora K., Zukow W.Козырев А. В. Гоженко А. И., Sikora K., Zukow W. International Technological University "Politehnica" Nikolaev (Mykolaiv)SE Research Institute of Medicine Transport (Odessa)WSG w BydgoszczyUKW w Bydgoszczy Международный технологический университет «Николаевская политехника» (г. Николаев)ГП НИИ Медицины транспорта (г. Одесса)WSG w BydgoszczyUKW w Bydgoszczy  Ключевые слова: полиморфизм, A1470T, ген, MCT1, выносливость, скорость, спортсменKey words: polymorphism, A1470T, gene, MCT1, speed, endurance, sportsman   РезюмеС усовершенствованием методов молекулярной биологии появилась возможность определения спортивных задатков с использованием генетических маркеров уже при рождении человека. В связи с этим внедрение молекулярно-генетических методов в практику спортивной науки существенно повысило прогностические возможности спортивного отбора и профессиональной ориентации и привело к формированию нового раздела спортивной науки – молекулярной генетики спорта [1].Целью исследования было определение возможности проведения спортивного отбора в академическую греблю и лёгкую атлетику на основании результатов молекулярно-генетического анализа полиморфизма A1470T гена MCT1.Объектом исследования была физическая работоспособность спортсменов, специализирующихся в академической гребле и лёгкой атлетике.Предметом исследования были молекулярно-генетические факторы обуславливающие физическую работоспособность спортсменов.В исследовании приняло участие 40 человек – 2 группы по 20 человек вкаждой. Опытную группу составили профессиональные спортсмены высокой квалификации, специализирующиеся в академической гребле. На момент проведения исследований, 15 спортсменов были мастерами спорта и 5 – мастерами спорта международного класса. Контрольную группу составили профессиональные спортсмены высокой квалификации, специализирующиеся в лёгкой атлетике, а именно в беге на спринтерские дистанции. На момент проведения исследований, 12 спортсменов были мастерами спорта и 8 – мастерами спорта международного класса. Возраст участников обоих групп составил от 19 до 25 лет.Полученные результаты позволяют сделать предположение о том, что превалирующая у спортсменов-гребцов аллель, является молекулярно-генетическим критерием склонности к выполнению физической деятельности, связанной с проявлением выносливости и связана с предрасположенностью к занятиям академической греблей.Превалирующая у спортсменов-легкоатлетов аллель, является молекулярно-генетическим критерием склонности к выполнению физической деятельности, связанной с проявлением скоростных качеств и связана с предрасположенностью к занятиям легкой атлетикой, а именно её спринтерскими беговыми дисциплинами. Данные аллели, могут быть рекомендованы в качестве диагностических генетических маркеров для оценки склонности к развитию и проявлению выносливости и скорости. SummaryImprovements in methods in molecular biology, it became possible to determine sporting inclinations using genetic markers already at birth man. In this connection, the introduction of molecular genetic methods in the practice of Sport Science has significantly increased predictive ability of sports and vocational guidance and selection led to the formation of a new section of sports science-molecular genetics sport [1]. The aim of the study was to determine the feasibility of holding sports selection in academic rowing and athletics on the basis of the results of molecular-genetic analysis of A1470T gene polymorphism MCT1. The object of the study was the physical performance of athletes specialised in rowing and athletics. The subject study were molecular genetic factors behind physical performance of athletes.In a study of 40 people participated-2 unit for 20 people each. Experimental group consisted of highly qualified professional athletes specialised in rowing. At the time of research, the 15 athletes were masters of sports and 5-Masters of sports of the international class. A control group consisted of professional athletes of high qualification, specializing in athletics, namely in the Sprint distance. At the time of research, 12 athletes were masters of sports and 8-masters of sports of the international class. Age of participants in both groups ranged from 19 to 25 years.The results lead to the assumption that prevailing in athletes-rowers allele, is a molecular genetic criterion propensity to perform physical activities related to the display of endurance and is associated with a predisposition to rowing lessons.The prevailing in athletes-athletes allele, is a molecular genetic propensity to fulfill the criterion of physical activity associated with the appearance of high-speed characteristics and is associated with a predisposition to athletics, namely its cross-country sprint disciplines. These alleles can be recommended as a diagnostic genetic markers for assessing the propensity for the development and manifestation of endurance and speed

The study of functional and metabolic continuum by metabolism parameters in blood plasma of healthy people as compared with patients with type 2 diabetes and hypertension against the background of type 2 diabetes

It is known that existing systems of regulation of energy homeostasis provide adequate needs of the body, depending on both the receipt and use of energy. Moreover, the organization of energy supply has its own characteristics in insulin-dependent and insulin-independent tissues. The main thing in the organization of energy supply is the achievement of the principle of compliance with the functional needs of the body, that is, the maintenance of the functional and metabolic continuum (FMC) We studied the metabolic parameters of FMC in healthy people and patients with type 2 DM and patients with hypertension against the background of type 2 DM according to the study of some indicators of blood plasma. The identified features, in our opinion, are one of the first manifestations of FMC disorder due to insulin resistance With the advent of insulin deficiency, there are increasing disturbances of energy metabolism, which are mainly caused by endothelial dysfunction and neuro-hormonal regulatory shifts of a stressful nature. The consequences or manifestations of these processes can probably be found in all environments of the body: blood, saliva, condensed air, that is, they have a systemic character