Origin and Evolution of Deep Brain Stimulation

This paper briefly describes how the electrical stimulation, used since antiquity to modulate the nervous system, has been a fundamental tool of neurophysiologic investigation in the second half of the eighteenth century and was subsequently used by the early twentieth century, even for therapeutic purposes. In mid-twentieth century the advent of stereotactic procedures has allowed the drift from lesional to stimulating technique of deep nuclei of the brain for therapeutic purposes. In this way, deep brain stimulation (DBS) was born, that, over the last two decades, has led to positive results for the treatment of medically refractory Parkinson’s disease, essential tremor, and dystonia. In recent years, the indications for therapeutic use of DBS have been extended to epilepsy, Tourette’s syndrome, psychiatric diseases (depression, obsessive–compulsive disorder), some kinds of headache, eating disorders, and the minimally conscious state. The potentials of the DBS for therapeutic use are fascinating, but there are still many unresolved technical and ethical problems, concerning the identification of the targets for each disease, the selection of the patients and the evaluation of the results

Particle-in-cell simulations of shock-driven reconnection in relativistic striped winds

By means of two- and three-dimensional particle-in-cell simulations, we investigate the process of driven magnetic reconnection at the termination shock of relativistic striped flows. In pulsar winds and in magnetar-powered relativistic jets, the flow consists of stripes of alternating magnetic field polarity, separated by current sheets of hot plasma. At the wind termination shock, the flow compresses and the alternating fields annihilate by driven magnetic reconnection. Irrespective of the stripe wavelength "lambda" or the wind magnetization "sigma" (in the regime sigma>>1 of magnetically-dominated flows), shock-driven reconnection transfers all the magnetic energy of alternating fields to the particles, whose average Lorentz factor increases by a factor of sigma with respect to the pre-shock value. In the limit lambda/(r_L*sigma)>>1, where r_L is the relativistic Larmor radius in the wind, the post-shock particle spectrum approaches a flat power-law tail with slope around -1.5, populated by particles accelerated by the reconnection electric field. The presence of a current-aligned "guide" magnetic field suppresses the acceleration of particles only when the guide field is stronger than the alternating component. Our findings place important constraints on the models of non-thermal radiation from Pulsar Wind Nebulae and relativistic jets.Comment: 25 pages, 14 figures, movies available at https://www.cfa.harvard.edu/~lsironi/sironi_movies.tar ; in press, special issue of Computational Science and Discovery on selected research from the 22nd International Conference on Numerical Simulation of Plasma

Do couples who use fertility treatments divorce more? Evidence from the US National Survey of Family Growth

BACKGROUND Undertaking fertility treatment is a stressful process and may lead to couple instability, but high levels of couple satisfaction have usually been observed during or just after treatment. However, the evidence on divorce is scarce. OBJECTIVES We investigated the association between the use of a wide range of fertility treatments and marital dissolution in a representative sample of American women in their first marriage. METHODS We applied discrete-time event history analysis to data from the US National Survey of Family Growth (NSFG), collected from 2002 through 2013‒2015, to compare divorce rates among women who experienced successful treatments or unsuccessful treatments and a natural birth or no birth within the marriage (N = 13,784). RESULTS Women who used fertility treatments had a lower risk of divorce up to 20 years after the marriage, compared to the other groups. The probability was especially low when the treatment was successful, but women who did not conceive after the treatment also showed a lower risk of divorce. CONCLUSION We found evidence that undertaking fertility treatment is associated with a lower risk of divorce, suggesting that it might strengthen couples’ relationships. The sociodemographic characteristics of couples undertaking treatment partly explained the association, but we were not able to control for the quality of the relationship before the treatment, which is likely to play a role

Radio light curves during the passage of cloud G2 near Sgr A*

We calculate radio light curves produced by the bow shock that is likely to form in front of the G2 cloud when it penetrates the accretion disk of Sgr A*. The shock acceleration of the radio-emitting electrons is captured self-consistently by means of first-principles particle-in-cell simulations. We show that the radio luminosity is expected to reach maximum in early 2013, roughly a month after the bow shock crosses the orbit pericenter. We estimate the peak radio flux at 1.4 GHz to be 1.4 - 22 Jy depending on the assumed orbit orientation and parameters. We show that the most promising frequencies for radio observations are in the 0.1<nu<1 GHz range, for which the bow shock emission will be much stronger than the intrinsic radio flux for all the models considered.Comment: 15 pages, 10 figures, accepted for publication in MNRA

Acceleration in perpendicular relativistic shocks for plasmas consisting of leptons and hadrons

We investigate the acceleration of light particles in perpendicular shocks for plasmas consisting of a mixture of leptonic and hadronic particles. Starting from the full set of conservation equations for the mixed plasma constituents, we generalize the magneto-hydrodynamical jump conditions for a multi-component plasma, including information about the specific adiabatic constants for the different species. The impact of deviations from the standard model of an ideal gas is compared in theory and particle-in-cell simulations, showing that the standard-MHD model is a good approximation. The simulations of shocks in electron-positron-ion plasmas are for the first time multi-dimensional, transverse effects are small in this configuration and 1D simulations are a good representation if the initial magnetization is chosen high. 1D runs with a mass ratio of 1836 are performed, which identify the Larmor frequency \omega_{ci} as the dominant frequency that determines the shock physics in mixed component plasmas. The maximum energy in the non-thermal tail of the particle spectra evolves in time according to a power-law proportional to t^\alpha with \alpha in the range 1/3 < \alpha < 1, depending on the initial parameters. A connection is made with transport theoretical models by Drury (1983) and Gargate & Spitkovsky (2011), which predict an acceleration time proportional to \gamma and the theory for small wavelength scattering by Kirk & Reville (2010), which predicts a behavior rather as proportional to \gamma^2. Furthermore, we compare different magnetic field orientations with B_0 inside and out of the plane, observing qualitatively different particle spectra than in pure electron-ion shocks

A dual output polarimeter devoted to the study of the Cosmic Microwave Background

We have developed a correlation radiometer at 33 GHz devoted to the search for residual polarization of the Cosmic Microwave Background (CMB). The two instruments`s outputs are linear combination of two Stokes Parameters (Q and U or U and V). The instrument is therefore directly sensitive to the polarized component of the radiation (respectively linear and circular). The radiometer has a beam-width oif 7 or 14 deg, but it can be coupled to a telescope increasing the resolution. The expected CMB polarization is at most a part per milion. The polarimeter has been designed to be sensitive to this faint signal, and it has been optimized to improve its long term stability, observing from the ground. In this contribution the performances of the instrument are presented, together with the preliminary test and observations.Comment: 12 pages, 6 figures, in print on the Proc. SPIE Conf. - August 200

Particle Acceleration in Pulsar Wind Nebulae: PIC modelling

We discuss the role of particle-in-cell (PIC) simulations in unveiling the origin of the emitting particles in PWNe. After describing the basics of the PIC technique, we summarize its implications for the quiescent and the flaring emission of the Crab Nebula, as a prototype of PWNe. A consensus seems to be emerging that, in addition to the standard scenario of particle acceleration via the Fermi process at the termination shock of the pulsar wind, magnetic reconnection in the wind, at the termination shock and in the Nebula plays a major role in powering the multi-wavelength signatures of PWNe.Comment: 32 pages, 16 figures, to appear in the book "Modelling Nebulae" edited by D. Torres for Springer, based on the invited contributions to the workshop held in Sant Cugat (Barcelona), June 14-17, 201

TRIS II: search for CMB spectral distortions at 0.60, 0.82 and 2.5 GHz

With the TRIS experiment we have performed absolute measurements of the sky brightness in a sky circle at $\delta = +42^{\circ}$ at the frequencies $\nu =$ 0.60, 0.82 and 2.5 GHz. In this paper we discuss the techniques used to separate the different contributions to the sky emission and give an evaluation of the absolute temperature of the Cosmic Microwave Background. For the black-body temperature of the CMB we get: $T_{cmb}^{th}=(2.837 \pm 0.129 \pm 0.066)K$ at $\nu=0.60$ GHz; $T_{cmb}^{th}=(2.803 \pm 0.051 ^{+0.430} _{-0.300})K$ at $\nu=0.82$ GHz; $T_{cmb}^{th}=(2.516 \pm 0.139 \pm 0.284)K$ at $\nu=2.5$ GHz. The first error bar is statistic (1$\sigma$) while the second one is systematic. These results represent a significant improvement with respect to the previous measurements. We have also set new limits to the free-free distortions, $-6.3 \times 10^{-6} < Y_{ff} < 12.6 \times 10^{-6}$, and slightly improved the Bose-Einstein upper limit, $|\mu| < 6 \times 10^{-5}$, both at 95% confidence level.Comment: accepted for publication in The Astrophysical Journa