Wormhole throats in <i> R ^m </i> gravity

We consider wormhole geometries subject to a gravitational action consisting of non-linear powers of the Ricci scalar. Specifically, wormhole throats are studied in the case where Einstein gravity is supplemented with a Ricci-squared and inverse Ricci term. In this modified theory it is found that static wormhole throats respecting the weak energy condition can exist. The analysis is done locally in the vicinity of the throat, which eliminates certain restrictions on the models introduced by considering the global topology.Comment: 12 pages, 3 figures. Update includes more references and clarification that "zero tidal force" class of models are considered. Accepted for publication in Classical and Quantum Gravit

Tropical cyanobacterial blooms: A review of prevalence, problem taxa, toxins and influencing environmental factors

© 2015, Page Press Publications. All rights reserved. Toxic cyanobacterial blooms are a major issue in freshwater systems in many countries. The potentially toxic species and their ecological causes are likely to be different in tropical zones from those in temperate water bodies; however, studies on tropical toxic cyanobacterial blooms are sporadic and currently there is no global synthesis. In this review, we examined published information on tropical cyanobacterial bloom occurrence and toxin production to investigate patterns in their growth and distribution. Microcystis was the most frequently occurring bloom genus throughout tropical Asia, Africa and Central America, while Cylindrospermopsis and Anabaena blooms occurred in various locations in tropical Australia, America and Africa. Microcystis blooms were more prevalent during the wet season while Cylindrospermopsis blooms were more prevalent during the dry period. Microcystin was the most encountered toxin throughout the tropics. A meta-analysis of tropical cyanobacterial blooms showed that Microcystis blooms were more associated with higher total nitrogen concentrations, while Cylindrospermopsis blooms were more associated with higher maximum temperatures. Meta-analysis also showed a positive linear relationship between levels of microcystin and N:P (nitrate:phosphate) ratio. Tropical African Microcystis blooms were found to have the lowest microcystin levels in relation to biomass and N:P (nitrate:phosphate) compared to tropical Asian, Australian and American blooms. There was also no significant correlation between microcystin concentration and cell concentration for tropical African blooms as opposed to tropical Asian and American blooms. Our review illustrates that some cyanobacteria and toxins are more prevalent in tropical areas. While some tropical countries have considerable information regarding toxic blooms, others have few or no reported studies

Reproductive ecology of wrinkle-lipped free-tailed bats Chaerephon plicatus (Buchannan, 1800) in Rrelation to Guano Production in Cambodia

Wildlife populations in Southeast Asia are subject to increasing pressure from climate change, habitat loss and human disturbance. Cave-roosting bats are particularly vulnerable to all three factors. Because of the ecological services they provide, it is important to assess specific vulnerabilities to inform their conservation management. We evaluated the reproductive phenology and body condition of Chaerephon plicatus for 14 months in 2015–2016 and quantified guano harvesting at the largest colony in Cambodia in 2011–2016. As in Thailand and Myanmar, two annual breeding cycles were recorded, characterized as continuous bimodal polyoestry, with parturition primarily occurring in April and October. Significant declines occurred in body condition between the late wet season and the late dry season, suggesting that bats experience increasing energetic stress as the dry season progresses. Annual guano harvests increased over the study period but could not be used as a proxy for monitoring population size due to the loss of unknown amounts during the wet season and unquantified movements of bats between C. plicatus colonies in the region. We recommend studies to determine the scale and drivers of such movements and creation of sustainable guano harvesting and population monitoring initiatives to ensure the conservation of C. plicatus colonies in Cambodia

Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts

BACKGROUND: The replication of mammalian genomic DNA during the S phase is a highly coordinated process that occurs in a programmed manner. Recent studies have begun to elucidate the pattern of replication timing on a genomic scale. Using a combination of experimental and computational techniques, we identified a genome-wide set of the earliest replicating sequences. This was accomplished by first creating a cosmid library containing DNA enriched in sequences that replicate early in the S phase of normal human fibroblasts. Clone ends were then sequenced and aligned to the human genome. RESULTS: By clustering adjacent or overlapping early replicating clones, we identified 1759 "islands" averaging 100 kb in length, allowing us to perform the most detailed analysis to date of DNA characteristics and genes contained within early replicating DNA. Islands are enriched in open chromatin, transcription related elements, and Alu repetitive elements, with an underrepresentation of LINE elements. In addition, we found a paucity of LTR retroposons, DNA transposon sequences, and an enrichment in all classes of tandem repeats, except for dinucleotides. CONCLUSION: An analysis of genes associated with islands revealed that nearly half of all genes in the WNT family, and a number of genes in the base excision repair pathway, including four of ten DNA glycosylases, were associated with island sequences. Also, we found an overrepresentation of members of apoptosis-associated genes in very early replicating sequences from both fibroblast and lymphoblastoid cells. These data suggest that there is a temporal pattern of replication for some functionally related genes

F-Seq: a feature density estimator for high-throughput sequence tags

Summary: Tag sequencing using high-throughput sequencing technologies are now regularly employed to identify specific sequence features, such as transcription factor binding sites (ChIP-seq) or regions of open chromatin (DNase-seq). To intuitively summarize and display individual sequence data as an accurate and interpretable signal, we developed F-Seq, a software package that generates a continuous tag sequence density estimation allowing identification of biologically meaningful sites whose output can be displayed directly in the UCSC Genome Browser

CLIMODE bobber data report : July 2005 - May 2009

This report summarizes direct observations of Eighteen Degree Water (EDW) subduction and dispersal within the subtropical gyre of the North Atlantic Ocean. Forty acoustically-tracked bobbing, profiling floats (“bobbers”) were deployed to study the formation and dispersal of EDW in the western North Atlantic. The unique bobber dataset described herein provides insight into the evolution of EDW by means of direct, eddy-resolving measurement of EDW Lagrangian dispersal pathways and stratification. Bobbers are modified Autonomous Profiling Explorer (APEX) profiling floats which actively servo their buoyancy control mechanism to follow a particular isothermal surface. The CLIVAR Mode Water Dynamics Experiment (CLIMODE) bobbers tracked the 18.5°C temperature surface for 3 days, then bobbed quickly between the 17°C and 19°C isotherms. This cycle was repeated for one month, after which each bobber profiled to 1000 m before ascending to the surface to transmit data. The resulting dataset (37/40 tracked bobbers; more than half still profiling as of January 2010) yields well-resolved trajectories, unprecedented velocity statistics in the core of the subducting and spreading EDW, and detailed information about the Lagrangian evolution of EDW thickness and vertical structure. This report provides an overview of the experimental procedure employed and summarizes the initial processing of the bobber dataset.Funding was provided by the National Science Foundation under Grant No. OCE-0424492

Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission from Depression.

BACKGROUND: Ketamine as an antidepressant improves anhedonia as early as 2h post-infusion. These drug effects are thought to be exerted via actions on reward-related brain areas-yet, these actions remain largely unknown. Our study investigates ketamine's effects during the anticipation and receipt of an expected reward, after the psychotomimetic effects of ketamine have passed, when early antidepressant effects are reported. METHODS: We examined ketamine's effects during the anticipation and receipt of expected rewards on pre-defined brain areas, namely the dorsal and ventral striatum, the ventral tegmental area, the amygdala and the insula. We have recruited 37 male and female participants who remitted from depression and were free from symptoms and antidepressant treatments at the time of the scan. Participants were scanned, 2h after drug administration, in a double-blind cross over design (ketamine:0.5mg/kg and placebo) while performing a monetary reward task. RESULTS: A significant main effect of ketamine, across all ROIs, was observed during the anticipation and feedback phases of win and no-win trials. The drug effects were particularly prominent in the nucleus accumbens and putamen, which showed increased activation upon the receipt of smaller rewards compared to neutral. The levels of (2R,6R)-HNK, 2h post-infusion, significantly correlated with the activation observed in the ventral tegmental area for that contrast. CONCLUSIONS: These findings demonstrate that ketamine can produce detectable changes in reward-related brain areas, 2h after infusion, which occur without symptom changes and support the idea that ketamine might improve reward-related symptoms via modulation of response to feedback

Food Insecurity and Lived Experience of Students (FILES)

This paper provides evidence of the impact of Covid-19 on higher education students’ levels of food security and lived experiences. We surveyed higher education students, attending three universities in the UK and one in the USA, from 1st April to 30th April 2020, during the Covid-19 pandemic and after universities closed the majority of their buildings and ceased campus-based teaching. A total of 1,234 surveys were returned. The preliminary findings show that nearly 35% of students surveyed reported low or very low levels of food security and 41% of students were worried that their food would run out. We also found high levels of poor mental health and well-being; and mental health was associated with level of food security. The best predictor of the level of food security was students’ living arrangements during the Covid-19 pandemic. Students who were living on their own or with other students were more likely to experience low or very low levels of food insecurity compared to those students living with family members. The financial data collected show that many students relied on employment as their main source of income, and students are very worried about their current financial security. Furthermore, we found a relatively high reliance on ultra-processed foods as the main food type in students’ diets. The data from open-ended questions lend further support to the quantitative findings reported and provide further insight into students’ lived experiences. Finally, this paper concludes with key recommendations for policy makers, universities and student unions. (Submitted to the Education Select Committee Inquiry on The impact of COVID-19 on education and children’s services, 03 June 2020) FILES is a research collaboration involving a number of academics and student union officers from across England, Northern Ireland and the USA. The group’s key objective is to research food insecurity and lived experiences of students in Higher Education. Food insecurity has been explored in other populations, but no evidence has been presented that examines food insecurity and lived experiences of students in higher education following Covid-19 lockdown. Authors: Professor Greta Defeyter, Professor Paul Stretesky, Dr Mike Long, Dr Sinéad Furey, Dr Christian Reynolds, Dr Alyson Dodds, Dr Debbie Porteous, Dr Emily Mann, Mrs Christine Stretesky, Ms Anna Kemp, Mr James Fox, Mr Andrew McAnalle