Strain Response of FBG at Liquid Nitrogen Temperature

对光纤Bragg光栅（FBG）液氮（77 K）下的应变传感技术及应变特性进行了研究.实验和分析表明：常温下FBG反射谱中的单个中心峰在低温下会劈裂为多峰,它产生于光纤、粘贴胶和金属基底热膨胀系数间的差异引起的强烈非均匀热弹性应变,使常温下均匀的光栅变啁啾化.建立了多种技术手段,成功消除了低温多峰现象,并测得了FBG低温和常温下的应变传感特性.实验结果表明：FBG的应变灵敏系数与温度无关

New Materials of Plants in Fujian Province (Ⅰ)

在泉州湾植物调查时,发现福建省被子植物分布新记录5种(含变种),分别是:盐地碱蓬SuAEdA SAlSA、座地猪屎豆CrOTAlArIA nAnA VAr.PATulA、沙地叶下珠PHyllAnTHuS ArEnArIuS、肉叶耳草HEdyOTIS STrIgulOSA和佛欧里画眉草ErAgrOSTIS fAurIEI。标本存放于厦门大学植物标本馆(Au)。During the course of investigating the plants in Quanzhou bay,four newly recorded species and one newly recorded varieties of Angiosperm were found.They are Suaeda salsa,Crotalaria nana var.patula,Phyllanthus arenarius,Hedyotis strigulosa and Eragrostis fauriei.The voucher specimens are deposited in the Herbarium of Xiamen University(AU).海洋公益性行业专项经费项目(200705029、200905009-1

间充质细胞外泌体促进小鼠胰岛内皮细胞血管生成的研究

目的探讨间充质细胞（MSC）外泌体对低氧条件下胰岛内皮细胞（MS-1）血管生成的影响。方法 MSC无血清低氧条件培养48 h,超滤离心法富集条件培养基中的外泌体,采用电镜和Western Blot的方法进行鉴定;通过血管形成试验比较分析不同条件下:常氧培养组（NOR组,21%O2、5%CO2）、低浓度氧培养组（HYP组,2%O2、5%CO2）、外泌体+低浓度氧共培养组（HYP+EXO组,2%O2、5%CO2）,MS-1细胞的血管形成能力;image J软件分析血管形成长度;PCR、Q-PCR检测血管内皮生长因子（VEGF） RNA水平的表达,Western Blot检测VEGF、HIF1α蛋白水平表达以及mTOR信号通路激活情况。采用单因素方差分析和SNK-q检验统计学分析。结果超滤离心法富集的MSC条件培养基中的外泌体,大小为30～100 nm,表达CD9,CD63,CD81等外泌体表面标志物;血管形成试验结果显示,低氧促进MS-1血管生成,HYP+EXO组形成明显的血管网状结构;HYP+EXO组血管形成相对长度（2386.0±137.7）像素与NOR组（393.3±174.2）像素和HYP组（1467.0±230.0）像素相比增强,差异有统计学意义（t=12.30,P=0.0065;t=15.74,P=0.0040）; PCR结果显示,HYP+EXO组VEGF相对表达量（20.26±9.972）较常氧对照组（1.000）和低氧组（6.521±3.501）均增强,差异有统计学意义（t=5.462,P=0.0009;t=4.238,P=0.0038）;同时,Western Blot结果显示VEGF蛋白水平表达升高,HIF1-α表达上调,mTOR发生磷酸化。结论 MSC外泌体可促进低氧条件下的小鼠胰岛内皮细胞血管生成。MSC外泌体可能通过上调HIF1-α,调节VEGF表达,激活mTOR信号通路,促进胰岛内皮细胞血管生成。国家自然科学基金青年项目(81601618);;福建省自然科学基金面上项目(2016J01582、2016J01580、2018J01349);;福建省科技创新联合资金重大项目(2017Y9127

骨髓间充质细胞联合PDMS支架构建移植胰岛微环境的实验研究

目的为了提高移植胰岛的活性和功能,构建适合移植胰岛生存的微环境。方法采用聚二甲基硅氧烷(PDMS)和氯化钠晶体构建三维支架,联合骨髓间充质细胞(MSCs)、纤维蛋白和胰岛共同构建迷你\"人工胰腺\"。采用链脲佐菌素(STZ)诱导的糖尿病大鼠移植模型评价效果,将\"人工胰腺\"移植到糖尿病大鼠大网膜内,对照组行假手术,术后隔天监测移植大鼠血糖水平;数据采用t检验和曼-惠特尼U检验。结果用PDMS构建的三维巨孔支架,支架内可见大量不规则孔洞空间。胰岛和MSCs可成功装载入支架内,HE染色结果显示,支架孔内存在胰岛,胰岛周围包绕有MSCs。糖尿病大鼠大网膜内移植结果显示,移植后各时间点(1,3,5,7 d),\"人工胰腺\"移植组糖尿病大鼠血糖水平分别为(278.70±86.06) mg/dl、(323.50±44.29) mg/dl、(283.30±74.00) mg/dl、(304.80±13.33) mg/dl,较假手术对照组(606.00±52.40) mg/dl、(589.70±55.78) mg/dl、(615.00±54.84) mg/dl、(630.30±48.17) mg/dl均降低,差异具有统计学意义(t=7.96、9.15、8.82,U=0.00,P均<0.01)。结论 MSCs联合PDMS三维支架构建的微环境,可为移植胰岛提供生存的环境,为临床开展胰岛移植提供新的策略

Discrepancies between patients’ and pharmacists’ perceptions of the role of community pharmacists as advisors on the use of pharmaceuticals in Japan: A comparison prior to and following revision of the Pharmacists’ Act

Objectives:In 2014, immediately prior to the revision of Article 25-2 of the Pharmacists’ Act, we conducted a survey on pharmacists’ and patients’ perceptions of pharmacists’ roles. A role discrepancy between the two was identified. The objective was to examine changes in role perceptions and awareness of pharmacists as medication specialists following revision to the Pharmacists’ Act.Methods:The survey was conducted using an Internet-based questionnaire. A total of 469 patients and 354 pharmacists responded to 12 questions about the perceived roles of pharmacists.Results:Analysis revealed that the only evaluation that changed as a result of revisions was pharmacists’ role as “family or regular pharmacist,” with scores dropping by about half. As in 2014, the high rating rate for pharmacists surpassed the high rating of patients for all other items. The greatest discrepancy in role perception was observed for the same three items (“Understanding the effects of the drugs the patients are taking,” “Understanding the health changes caused by the drugs dispensed to the patients,” and “Consciously protecting patients from the adverse effects of drugs”) as 2014.Conclusion:A major role discrepancy continues to exist between patients and pharmacists, and it is necessary for pharmacists to take on a more advanced role in patient care. Results suggest that pharmacists must monitor changes in patients’ lifestyles and provide clear explanations for patients to rate them highly as medication specialists.This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage)

Trisomy 21-induced Dysregulation of Microglial Homeostasis in Alzheimer’s Brains is Mediated by USP25

阿尔茨海默病（Alzheimer’s disease, AD）是一种最为常见的与记忆、认知能力退化相关的渐进性神经退行性疾病。唐氏综合征（Down’s syndrome, DS）是早发型阿尔茨海默病的一个重要风险因素，作为最常见的智力障碍遗传疾病，厦门大学医学院神经科学研究所王鑫教授团队揭示了治疗阿尔茨海默病和唐氏综合征新的治疗靶点，并且在小鼠模型上利用USP25小分子抑制剂成功地改善了阿尔茨海默病小鼠的认知功能，缓解了神经退行性病变的病理进程。该研究工作由王鑫教授指导完成，厦门大学医学院助理教授郑秋阳和博士生李桂林完成主要实验工作，王世华、朱琳、高月、邓青芳、张洪峰、张丽珊、吴美玲、狄安洁参与了部分研究工作。厦门大学医学院许华曦、赵颖俊和孙灏教授在研究过程中给予大力帮助和支持，清华大学董晨教授提供了Usp25基因敲除小鼠，厦门大学附属妇女儿童医院周裕林教授和郑良楷博士帮助收集了脑组织样品。Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer’s disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of USP25, a deubiquitinating enzyme encoded by chromosome 21, results in microglial activation and induces synaptic and cognitive deficits, whereas genetic ablation of Usp25 reduces neuroinflammation and rescues synaptic and cognitive function in 5×FAD mice. Mechanistically, USP25 deficiency attenuates microglia-mediated proinflammatory cytokine overproduction and synapse elimination. Inhibition of USP25 reestablishes homeostatic microglial signatures and restores synaptic and cognitive function in 5×FAD mice. In summary, we demonstrate an unprecedented role for trisomy 21 and pathogenic effects associated with microgliosis as a result of the increased USP25 dosage, implicating USP25 as a therapeutic target for neuroinflammation in DS and AD.This work was supported by the National Natural Science Foundation of China (31871077, 81822014, and 81571176 to X.W.; 81701130 to Q.Z.), the National Key R&D Program of China (2016YFC1305900 to X.W.), the Natural Science Foundation of Fujian Province of China (2017J06021 to X.W.), the Fundamental Research Funds for the Chinese Central Universities (20720150061 to X.W.), and the BrightFocus Foundation (A2018214F to Yingjun Zhao). 该研究工作得到国家重点研发计划项目、国家自然科学基金、福建省自然科学基金、厦门大学校长基金的资助和支持

探討不同床質型態對流體化床焚化爐去流體化行為之影響

[[abstract]]本研究為探討不同組成的床質對流體化床焚化爐去流體化之影響。配製不同組成的人工模擬廢棄物，來模擬燒結的產生。而床質種類分為四種：單一(Narrow)、二元(Binary)、平坦(Flat)及高斯(Gaussian)。並加入不同操作溫度、氣速及鹼金屬含量來探討對流體化床焚化爐去流體化之影響。實驗結果顯示隨著操作溫度的提升，其結塊去流體化的時間隨溫度增加而下降。而隨著操作氣速的增加，會使結塊去流體化的時間延長。而在Na濃度部分，當模擬廢棄物的Na濃度由0.5 %提升至0.9 %時，其結塊去流體化的時間隨Na濃度增加而明顯降低。而比較床質型態的影響，無論操作溫度、氣速及進料物Na含量為何，其去流體化時間皆是Narrow > Gaussian > Binary ≒ Flat。而由實驗結果亦顯示當氣速越低、溫度及Na濃度含量越高時，較床質本身特性對去流體化的影響較不明顯

液氮温区下光纤布拉格光栅应变传感器测量性能的研究

基于光纤布拉格光栅传感器的原理,研究了在液氮浸泡情况下光纤布拉格光栅应变传 感器的静态传输特性. 实验过程中利用悬臂梁原理和美国Micron Optics 公司生产的光栅波 长可调谐激光扫描法解调系统,分别测量了液氮浸泡中的悬臂梁的正应变和负应变,确定了 在液氮温度下悬臂梁应变与光纤光栅波长偏移量之间的关系. 为测量高温超导磁体的应变 提供了新的方法