A Curriculum Reform on University Teaching of Visual Communication Deasign at the New era

随着我国当前社会经济的发展、市场经济的转型和创意产业的兴起，我国设计教育领域迎来了前所未有的发展契机。面对发展创新型国家的战略机遇，设计教育如何培养出更多优秀的设计人才，成为设计教育界面临的严峻挑战。 而我国目前的设计教育还存在诸多问题。学校是教育人才培养的基地，而学校在培养人才的过程中在形式上一味追逐社会发展的脚步，却忽视了设计人员的质量培养，造成了目前设计人员数量与质量的不平衡。本文从我国目前视觉传达设计的教学现状出发，分析眼下设计人才培养中存在的种种问题，并结合国外发达国家的教学经验，提出对当下视觉传达设计专业课程改革的建议，以期对我国当前的设计教育改革有所启示。 本文共分为四个章节...With our current economic and social development and the rise of creative industries, Design education in China has embraced an unprecedented development opportunity. In the face of strategic opportunity of the development of an innovative country how to cultivate more excellent design talent in design Education is becoming a challenge of design education. But,there are many problems in our desi...学位：文学硕士院系专业：艺术教育学院美术系_美术学学号：1862007115165

Extended IR Service Trends

介绍环境变化扫描和IR深度服务的方向与趋势。</p

新媒体时代传播研究转型问题分析

新媒体时代给媒体传播带来一定的影响,从而引起了传播学界观念的变化。而伴随着媒体传播的变化发展,在传播认识、传播技术和传播活动方面,传播研究的内容也开始发生变化。本文在分析新媒体时代传播研究转型情况的基础上,对传播研究在新媒体时代的转型策略展开了探讨

The measure of active learning state among healthcare undergraduates

2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

间充质细胞外泌体促进小鼠胰岛内皮细胞血管生成的研究

目的探讨间充质细胞（MSC）外泌体对低氧条件下胰岛内皮细胞（MS-1）血管生成的影响。方法 MSC无血清低氧条件培养48 h,超滤离心法富集条件培养基中的外泌体,采用电镜和Western Blot的方法进行鉴定;通过血管形成试验比较分析不同条件下:常氧培养组（NOR组,21%O2、5%CO2）、低浓度氧培养组（HYP组,2%O2、5%CO2）、外泌体+低浓度氧共培养组（HYP+EXO组,2%O2、5%CO2）,MS-1细胞的血管形成能力;image J软件分析血管形成长度;PCR、Q-PCR检测血管内皮生长因子（VEGF） RNA水平的表达,Western Blot检测VEGF、HIF1α蛋白水平表达以及mTOR信号通路激活情况。采用单因素方差分析和SNK-q检验统计学分析。结果超滤离心法富集的MSC条件培养基中的外泌体,大小为30～100 nm,表达CD9,CD63,CD81等外泌体表面标志物;血管形成试验结果显示,低氧促进MS-1血管生成,HYP+EXO组形成明显的血管网状结构;HYP+EXO组血管形成相对长度（2386.0±137.7）像素与NOR组（393.3±174.2）像素和HYP组（1467.0±230.0）像素相比增强,差异有统计学意义（t=12.30,P=0.0065;t=15.74,P=0.0040）; PCR结果显示,HYP+EXO组VEGF相对表达量（20.26±9.972）较常氧对照组（1.000）和低氧组（6.521±3.501）均增强,差异有统计学意义（t=5.462,P=0.0009;t=4.238,P=0.0038）;同时,Western Blot结果显示VEGF蛋白水平表达升高,HIF1-α表达上调,mTOR发生磷酸化。结论 MSC外泌体可促进低氧条件下的小鼠胰岛内皮细胞血管生成。MSC外泌体可能通过上调HIF1-α,调节VEGF表达,激活mTOR信号通路,促进胰岛内皮细胞血管生成。国家自然科学基金青年项目(81601618);;福建省自然科学基金面上项目(2016J01582、2016J01580、2018J01349);;福建省科技创新联合资金重大项目(2017Y9127

骨髓间充质细胞联合PDMS支架构建移植胰岛微环境的实验研究

目的为了提高移植胰岛的活性和功能,构建适合移植胰岛生存的微环境。方法采用聚二甲基硅氧烷(PDMS)和氯化钠晶体构建三维支架,联合骨髓间充质细胞(MSCs)、纤维蛋白和胰岛共同构建迷你\"人工胰腺\"。采用链脲佐菌素(STZ)诱导的糖尿病大鼠移植模型评价效果,将\"人工胰腺\"移植到糖尿病大鼠大网膜内,对照组行假手术,术后隔天监测移植大鼠血糖水平;数据采用t检验和曼-惠特尼U检验。结果用PDMS构建的三维巨孔支架,支架内可见大量不规则孔洞空间。胰岛和MSCs可成功装载入支架内,HE染色结果显示,支架孔内存在胰岛,胰岛周围包绕有MSCs。糖尿病大鼠大网膜内移植结果显示,移植后各时间点(1,3,5,7 d),\"人工胰腺\"移植组糖尿病大鼠血糖水平分别为(278.70±86.06) mg/dl、(323.50±44.29) mg/dl、(283.30±74.00) mg/dl、(304.80±13.33) mg/dl,较假手术对照组(606.00±52.40) mg/dl、(589.70±55.78) mg/dl、(615.00±54.84) mg/dl、(630.30±48.17) mg/dl均降低,差异具有统计学意义(t=7.96、9.15、8.82,U=0.00,P均<0.01)。结论 MSCs联合PDMS三维支架构建的微环境,可为移植胰岛提供生存的环境,为临床开展胰岛移植提供新的策略

Analysis of genetic effects for grain quality characters in late indica hybrid rice

以6个籼型野败三系不育系为母本,5个晚籼恢复系为父本,进行不完全双列杂交设计,对籼型杂交晚稻稻米品质性状的遗传效应进行分析.结果表明:糙米率、精米率、垩白粒率、碱消值和胶稠度等5个性状同时受到种子遗传效应和细胞质遗传效应的控制,但细胞质遗传效应都大于种子遗传效应.整精米率、垩白度和透明度等3个性状只受到种子遗传效应的控制,并且都以种子显性遗传效应为主.直链淀粉含量同时受到种子遗传效应和母体植株遗传效应的控制,但以种子显性遗传效应为主.粒长和长宽比同时受到母体植株加性遗传效应和母体植株显性遗传效应的控制.不育系451A、全丰A、长丰A及恢复系蜀恢527、科恢752、岳恢94是配制优质杂交晚稻组合的优异亲本.Six CMS(Fuyi A etc.) and 5 late-restorers(Minghui 63 etc.) were used in partial diallel crosses to analyse the genetic effects of grain quality characters in late indica hybrid rice,using seed quantitative traits genetic models and analysis methods developed by Zhu Jun in cereal crops.The results showed that the 5 characters were simultaneously controlled by seed genetic effects and cytoplasmic genetic effects in percentage of brown rice,percentage of milled rice,percentage of chalky grain,gelatinization temperature and gel consistency,but the cytoplasmic genetic effects were all higher than the seed genetic effects.The 3 traits were only controlled by seed genetic effects in percentage of head rice,chalkiness and translucency,and the effects were all mainly come from seed dominance genetic effects.Amylose content was controlled by seed genetic effects and maternal genetic effects,but was mainly controlled by seed dominance genetic effects.The 2 traits were simultaneously controlled by maternal additive genetic effects and maternal dominance genetic effects in kernel length and length/breadth ratio.The 6 materials were available parents for breeding late indica hybrid rice combinations with good quality,which included the CMS of 451 A,Quanfeng A and Changfeng A,the restorers of Shuhui 527,Kehui 752 and Yuehui 94.福建省自然科学基金资助项目(B0310020