硫酸乙酰肝素蛋白聚糖在人乳头瘤病毒感染中的作用

人乳头瘤病毒(human papillomavirus,HPV)是一类无包膜的小DNA双链病毒,其衣壳蛋白由主要衣壳蛋白L1和次要衣壳蛋白L2组成,高危型HPV的持续感染是诱发宫颈癌的主要原因。HPV吸附入胞伴随着由多种受体引起衣壳蛋白L1和L2的变构,其中衣壳蛋白L1与细胞表面硫酸乙酰肝素蛋白聚糖(heparan sulfate proteoglycans,HSPG)之间的多重相互作用是病毒入胞的关键。经与HSPG相互作用后,HPV衣壳蛋白L2暴露病毒与入胞受体结合位点,进而介导病毒内吞入胞。因此,阐述HPSG在HPV感染细胞中的作用有助于进一步阐明HPV感染机制及致病机制,为HPV治疗性疫苗的研究提供一定的理论基础。本文就HSPG在HPV感染细胞中的作用进行综述。国家自然科学基金(31670935

やはりハイリスクアトピー児の母親は母乳を与えるならば鶏卵摂取の制限は必要ではないだろうか : 15年間のアレルギー検査の検討から

著者らは市立室蘭総合病院小児科で15年間にわたって持続する湿疹・咳・喘鳴・鼻汁・鼻閉などのある子どもと家族歴にアレルギー疾患のあるハイリスクアレルギーの子どもを対象にアレルギー検査をしてきた。総検査数は7871件でおよそ5000人の検査者のなかから1歳未満の乳児1263人を対象に母乳とアレルギー疾患の関連について特異的IgE 抗体のスコア値を中心に検討した。その結果、母乳由来による卵白アレルギーに対応するため早期介入すべきと考えた

使用層級分析法為基礎的評估機制進行演化式問題解決

出處：輔仁大

創造力支援系統 - 以資管專題論文製作為例

出處：真理大

以層級分析法為基礎的演化式知識取

出處：大葉大

Evolutionary Knowledge Acquisition Based on Analytic Hierarchy Process

出處：ICIC

MARine CarbOn Sequestration： Multiscale Regulation and Response to Global Changes

海洋是地表系统中最大的碳库，在全球碳循环中起着举足轻重的作用。显著影响地球气候系统。生物泵和微型生物碳泵是海洋储碳的两个重要途径，其储碳效率在很大程度上决定了海洋和大气中的碳库变动，是碳增汇的关键过程。本项目目标是阐明海洋固碳过程和储碳机理。诠释海洋酸化对固碳和储碳的影响．建立古海洋沉积碳库变动与全球变化的关联．深入揭示海洋生态系统储碳过程的多尺度调控机理。项目将从现代生物地球化学过程入手．研究不同层级水平上海洋生态系统的固碳过程、储碳机制及其对海洋酸化的响应：并结合不同沉积系统近2000年来的碳库变动，以及工业革命以来高分辨率的海水温度、pH值和碳库记录，探讨海洋碳库变动对自然变化和人类活动的响应机制．阐明生物泵和微型生物碳泵储碳的调控机理。项目的实施将显著提升我国在海洋碳循环和储碳机制研究领域的国际地位．为我国制定应对气候变化和实施海洋碳增汇政策提供科技支撑。Ocean is the largest carbon stock in the Earth, it plays an important role in the global carbon cycle, and significant impact on the Earth＇s climate system. Biological pump （BP） and microbial carbon pump （BCP） are two of the most important pathways for the carbon sequestrations, the efficiency of which determined the carbon stock changes in the ocean and atmosphere. The MARCO aims to clarify the ocean carbon sequestration mechanism of carbon process and interpretation of ocean acidification effect on carbon sequestration and storage, establish the ocean sedimentary carbon stock changes linked to global change, further analysis in the process of marine ecosystem carbon storage muhiscale regulation mechanism. According to the key scientific question and target, 4 themes ＂process of carbon fixation-carbon storage mechanism-acidification effect-sediment carbon stock changes＂ were set up around the core scientific question. Three typical ecological systems （eontinental shelf, basin and coral reefs） in the northern South China Sea with significant differences of biological community structure and carbon library changes were taken as the study sites. The MARCO will be initiated from the modern biogeochemical process, to demonstrate marine ecosystem carbon process and mechanism of carbon storage and its response to ocean acidification at different levels （gene protein-individual-species-community-ecosystem）. Combined with different carbon stock ehanges of sedimentary systems in 2000 years and high-resolution sea water temperature, pH and carbon library records since the industrial revolution, to explore the ocean carbon stock changes to natural changes and human activities in response mechanism, to clarify regulation mechanism of the biological pump and microbial carbon pump. The implementation of the MARCO will be a significant boost in the marine carbon cycle and carbon storage mechanism research in China, and provide data support for our country to make policies for dealing with climate change an致谢 科学技术部重点研发计划项目“全球变化及其应对”重点专项资助（2016YFA0601200）

Preliminary study on utilization of colloidal phosphorus in artificial seawater by two dinoflagellates

采用批次培养方法,研究了东海原甲藻(PrOrOCEnTruM dOngHAIEnSE)和链状亚历山大藻(AlEXAn-drIuM CATEnllA)对胶体磷的生物可利用性,并初步探讨了甲藻利用胶体磷的机制问题.结果表明东海原甲藻和链状亚历山大藻均能利用胶体磷生长繁殖.东海原甲藻在接种11 d后细胞密度在无机磷和胶体磷培养基中分别为10.53x107和3.43x107个/dM3.链状亚历山大藻在接种11 d后细胞密度在无机磷和胶体磷培养基中分别为39.0x105和28.3x105个/dM3.通过对比细胞密度,胶体磷对东海原甲藻生长的促进作用要低于无机磷的作用;胶体磷对链状亚历山大藻生长的促进作用与无机磷的作用相当.东海原甲藻和链状亚历山大藻在胶体磷源下碱性磷酸酶活性迅速升高,前期均显著高于各自无机磷组的碱性磷酸酶活性,碱性磷酸酶活力最高值分别为0.29和0.30μMOl/(dM3.H).初步结果表明,两种甲藻均能通过碱性磷酸酶的降解来利用胶体磷.Based on batch culture,the bioavailability of colloidal phosphorus(CP) for Prorocentrum donghaiense and Alexandrium catenlla was studied and the mechanism of dinoflagellate utilizing CP was preliminary discussed.The results showed that both species could utilize colloidal phosphorus for growth.For P.donghaiense,after 11 d,the cell densities of K2HPO4 and CP treatment were 10.53 × 107 and 3.43 × 107cells/dm3,respectively.For A.catenlla,after 11 days,the cell densities of K2HPO4 and CP treatment were 39.0 × 105 and 28.3 × 105 cells/dm3,respectively.The growth rate of P.donghaiense in CP was significantly lower than that in K2HPO4;while there is no significant difference between the effects of K2HPO4 and CP for A.catenlla's growth.In CP treatment,the concentrations of alkaline phosphatase activity of P.donghaiense and A.catenlla raised rapidly and got the highest values of 0.29 and 0.30 μmol/(dm3·h),respectively,both significantly higher than those in K2HPO4 treatment during early stage.Preliminary data showed that these 2 dinoflagellates could utilized CP via the induction of alkaline phosphatase.国家973计划资助项目(2011CB403603); 国家自然科学基金资助项目(41176112;40906040); 福建省自然科学基金资助项目(2011J01277); 国家海洋局海洋生态系统与生物地球化学重点实验室开放基金资助项目(LMEB201103