我国模糊网纹溞（甲壳纲：双甲目）的补充描述

我国模糊网纹溞（甲壳纲：双甲目）的补充描述陈受忠，张世萍，宋希强中国科学院水生生物研究所武汉４３００７２华中在业大学水产系日本Ｕｅｎｏ氏在记述中国台湾的枝角类一文￣［２］的名录表中列入了模糊网纹（Ｃｅｒｉｏ－ｄａｐｈｎｉａｄｕｂｉａＲｉｃｈａｒｄ，１..

海洋来源放线菌HN-E31次生代谢产物的分离与鉴定

利用反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备高效液相色谱等分离方法,对采自中国南海的鸟氨酸微菌属放线菌HN-E31发酵液乙酸乙酯萃取部位的化学成分进行分离研究,通过1H NMR、13C NMR和质谱等波谱技术,并参照相关文献数据,对化合物进行结构鉴定。结果共分离得到了12个化合物,分别鉴定为:环(脯-缬)二肽(1)、环(脯-亮)二肽(2)、环(脯-异亮)二肽(3)、环(脯-苯丙)二肽(4)、环(亮-丙)二肽(5)、环(异亮-丙)二肽(6)、苯丙氨酸(7)、3-hydroxyacetyl-indole(8)、3-吲哚甲醛(9)、水杨酸(10)、尿嘧啶(11)和对羟基苯甲醛(12)。上述化合物均为首次从鸟氨酸微菌属放线菌中分离获得。国家自然科学基金项目(31201969);;厦门市海洋与渔业局科研项目(17GYY008NF04)~

JIT Production Sequencing Based on Blended Genetic Algorithms

JIT管理方式是实施CIMS工程中的一种重要的生产管理方式 ,以消除制造过程中的一切浪费为宗旨 ,消除和降低企业生产经营中的各种浪费 ,降低产品的成本 ,从而给企业带来了巨大的效益。JIT管理方式近来被广泛地应用于企业的生产经营管理中。在JIT生产方式中如何设计最佳的投产顺序计划问题一直是一个难题。在前人研究成果的基础上 ,使用把原有算法和自调整参数遗传算法相结合的混合遗传算法来求解这个问题。仿真结果表明这种算法是行之有效的。JIT is an important way for a CIMS project. Aiming to eliminate all wastes in the process of manufacture, it is effective to eliminate and reduce all kinds of wastes in production management, and cut down the cost of products, thus bringing the manufacturer to great benefits. So JIT has been widely used during the pastyears. In JIT mode of production, it is a difficult problem on how to design the optimal sequence. In this paper, Blended genetic algorithms (BGA) combining the proximal solution with genetic algorithms (GA) is used to solve the problem. The simulations show that the BGA is effective.厦门大学工科专项经费资助课题 (3 0 0 3

雷帕霉素衍生物对胰岛的毒性研究

目的探讨雷帕霉素及其衍生物依维莫司、地磷莫司、佐他莫司对胰岛的毒性作用。方法采用小鼠胰岛素瘤细胞(MIN6)作为体外研究胰岛细胞的对象,分别在含有依维莫司、地磷莫司、佐他莫司的培养基中孵育MIN6细胞48小时,通过Brdu检测细胞增殖、CCK8检测细胞活力、PI检测细胞周期、流式细胞术检测细胞凋亡以及ELISA检测细胞分泌胰岛素功能,观察3种雷帕霉素衍生物对MIN6细胞的影响。结果我们发现3种雷帕霉素衍生物均会对MIN6细胞的增殖和活力产生抑制作用。在细胞周期和凋亡实验中,与阴性对照组比较,3种衍生物对MIN6细胞的影响呈现抑制G1期向S期转变的趋势和促进细胞凋亡的趋势,但差异没有统计学意义。另外,3种衍生物与雷帕霉素一样,均可减少MIN6细胞分泌胰岛素,差异具有统计学意义。结论雷帕霉素及其衍生物依维莫司、地磷莫司、佐他莫司均对胰岛产生一定毒性。国家自然科学基金项目(31271038,81302546

Comparison of gene frequencies of 15 STR loci between patients with primary gastric adencarcinomas and the unrelated locals from Xiamen

目的比较15个短串联重复序列(STR)基因座基因频率在原发性胃腺癌患者和厦门地区正常人群中的分布,推测与胃腺癌相关的基因。方法123份血样采自本地区无癌家族史的健康人群,39份血样采自本地区胃腺癌患者。用聚合酶链反应(PCR)复合扩增结合四色荧光检测方法对血样DNA进行基因型分析,调查本地区健康人群和胃腺癌患者人群的基因频率分布,并根据两者的该15个基因座等位基因频率分布的差异性,推测易感连锁和抗性连锁的等位基因。结果厦门地区胃腺癌患者的TH01、vWA和FAG基因座的等位基因的分布与该地区健康人群比较差异有统计学意义(P<0·01)。在个别等位基因比较中,胃腺癌人群TH01-7的基因频率为0·0385,健康人群TH01-7的基因频率为0·2642,两者差异有统计学意义(P<0·01),相对危险度(RR)=0·1115;胃腺癌人群vWA-15基因频率0·0513,健康人群vWA-15的基因频率0·2927,两者差异有统计学意义(P<0·01),RR=0·1307;胃腺癌人群FAG-18的基因频率为0·1026,健康人群FAG-18的基因频率为0·0163,两者差异有统计学意义(P<0·01),RR=6·8998。结论TH01-7与胃腺癌相关联,其附近可能存在胃腺癌抗性基因;vWA-15附近有可能存在与胃腺癌相关的抗性基因;FAG-18与胃腺癌相关联,其附近可能存在胃腺癌易感基因。Objective To compare the gene frequencies of 15 STR loci between patients with primary gastric adencarcinomas and the unrelated locals from Xiamen in order to search for the genes correlated to the gastric adencarcinomas.Methods The control group consisted of 123 unrelated locals and the testing group was composed of 39 gastric adencarcinomas suffers. All genotypes of the sample DNA were analyzed by gene scan technology and multiplex PCR method with 4-colored fluorescence-labeled primers. All the polymorphic alleles of these 15 STR loci in unrelated healthy locals and patients with primary gastric adencarcinomas had been investigated. The sensitive or resistant genetic factors were inferred according to the statistical difference with distribution of allele frequencies.Results It showed that there were statistic differences (P<0.01)between controls and testing groups in allele frequencies of the three loci: TH01, vWA and FAG. The further exploration of the separated locus revealed that the gene frequency of TH01-7 in the gastric adencarcinomas suffers was 0.0385,but 0.2642 in the control group[P<0.01 and relative risk(RR)=0.1115];the gene frequency of vWA-15 in the gastric adencarcinomas suffers was 0.0513,but 0.2927 in the control group(P<0.01 and RR=0.1307);the gene frequency of FAG-18 in the gastric adencarcinomas suffers was 0.1026,but 0.0163 in the control group(P<0.01 and RR= 6.8998). Conclusions It is very possible that TH01 alleles may be associated with gastric adencarcinomas and it is possible that there is a resistant gene to gastric adencarcinomas near the region of TH01-7 locus; there is a resistant gene of gastric adencarcinomas near the region of vWA-15 locus; FAG alleles may be associated with gastric adencarcinomas and perhaps there is a sensitive gene of gastric adencarcinomas near FAG-18 locus

高壳溞属的初步研究(甲壳纲:双甲目)

本文描述了中国淡水枝角类新记录种&mdash;&mdash;长吻高壳溞的外部形态,记述了某些生物学问题,其次详细观察并描述了头孔这一重要分类学特征。重新编列了高壳溞属分种检索表

中国隆背溞属（甲壳纲：双甲目）一新记录

描述了中国隆背　属的一新记录，补充了属的特征并编制了本属的分种检索表