Biologically active metabolites of plants. 10. Alkaloids of Fumaria officinalis L. and their biological activity

Šafratová M.: Biologicky aktivní metabolity rostlin 10. Alkaloidy Fumaria officinalis L. a jejich biologická aktivita. Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické botaniky a ekologie, Hradec Králové, 2013. Diplomová práce. 70 s. Předmětem diplomové práce bylo zpracování výtřepku alkaloidů z Fumaria officinalis L. (Fumariaceae). Pomocí sloupcové chromatografie a následně preparativního TLC byly izolovány tři alkaloidy, které byly podrobeny strukturní analýze (MS a NMR). První látka byla identifikována jako isochinolinový alkaloid stylopin, druhým izolovaným alkaloidem byl sinaktin a třetím izolovaným alkaloidem byl fumarilin. Všechny tři alkaloidy již byly dříve z F. officinalis izolovány. U všech tří alkaloidů byla testována jejich inhibiční aktivita vůči lidské erytrocytární acetylcholinesteráze (HuAChE) a lidské sérové butyrylcholinesteráze (HuBuChE). U stylopinu byly stanovené hodnoty IC50 HuAChE ˂ 1000 µM a IC50 HuBuChE ˂ 1000 µM. Pro sinaktin byly naměřeny hodnoty IC50 HuAChE = 632 ± 22 µM a IC50 HuBuChE ˂ 1000 µM. Hodnoty fumarilinu byly IC50 HuAChE ˂ 1000 µM a IC50 HuBuChE = 330 ± 12 µM. V porovnání se standardy byly stylopin, sinaktin i fumarilin málo aktivní. Žádná z izolovaných látek se proto nejeví jako léčivo vhodné v terapii Alzheimerovy...Šafratová M.: Biologically active metabolites of plants 10. Alkaloids of Fumaria officinalis L. and their biological aktivity. Charles University in Prague, Faculty of Pharmacy in Hradec Králové. Department of Pharmaceutical Botany and Ecology, Hradec Králové, 2013. Diploma thesis. 70 s. The object of this diploma thesis was to process the pool of alkaloids from Fumaria officinalis L. (Fumariaceae). Using column chromatography and preparative TLC three alkaloids were isolated which have been subjected to structural analysis (MS, NMR). The first substance was identified as isoquinoline alkaloid stylopin, others isolated alkaloid was sinactin and third isolated alkaloid was fumarilin. All three alkaloids have been previously isolated from F. officinalis. For all three alkaloids were tested for their inhibitory activity against human erythrocyte acetylcholinesterase (HuAChE) and human serum butyrylcholinesterase (HuBuChE). For stylopine IC50 values were determined IC50 HuAChE ˂ 1000 µM and IC50 HuBuChE ˂ 1000 µM. For sinactine were measured IC50 HuAChE = 632 ± 22 µM and IC50 HuBuChE ˂ 1000 µM. Values for fumariline IC50 HuAChE ˂ 1000 µM and IC50 HuBuChE = 330 ± 12 µM. In comparison with standards were stylopine, sinactine and fumariline not very active. None of the isolated compounds are therefore...Department of Pharmaceutical Botany and EcologyKatedra farmaceutické botaniky a ekologieFaculty of Pharmacy in Hradec KrálovéFarmaceutická fakulta v Hradci Králov

Children's reading surveys 2010 - 2016 in Europe: An Overview and Characteristics of Selected Surveys

Bakalářská práce ve svém úvodu stručně shrnuje koncept dětského čtenářství. Dále se věnuje vlivu rodiny na čtenářství dětí. Následně je zpracován přehled vyhledaných evropských výzkumů, které se věnují dětskému čtenářství, a analýza vybraných výzkumů s doporučeními pro český výzkum "České děti jako čtenáři". Klíčová slova Děti, čtenářství, výzkum, Evropa, rodinaThe bachelor thesis, in its introduction, briefly summarizes the concept of children's reading. It also focuses on the influence of the family on children's reading. Subsequently, an overview of searched European research devoted to child reading and analysis of selected research with recommendations for Czech research "Czech children as readers" is processed. Keywords Children, reading, research, Europe, familyInstitute of Information Studies and LibrarianshipÚstav informačních studií a knihovnictvíFilozofická fakultaFaculty of Art

Influence of family environment on adolescent reading

The diploma thesis, in its theoretical part, focuses on reading development, family environment in connection with reading and other factors, which influence reading. A list of other researches - foerign and Czech, which deal with adolescent reading - was also created. The aim of the work was to find out how the family environment and other factors affect the reading of adolescents. In practical part of this diploma thesis, the research of influence of family environment and other factors on reading of adolescents was made. The methods of questionnaire, focus group and individual qualitative interviews were used. Keywords Adolescents, reading, family, influence of family environment, factors influencing readingDiplomová práce se ve své teoretické části zabývá čtenářským vývojem, rodinným prostředím ve spojitosti se čtenářstvím a dalšími faktory, které čtenářství ovlivňují. Vytvořen byl také seznam dalších výzkumů - zahraničních a českých, které se čtenářstvím adolescentů zabývají. Cílem práce bylo zjistit, jak rodinné prostředí a další faktory ovlivňují čtenářství adolescentů. V praktické části tak byl proveden vlastní výzkum vlivu rodinného prostředí a dalších faktorů na čtenářství adolescentů. Použity byly metody dotazníku, focus group a individuálních kvalitativních rozhovorů. Klíčová slova Adolescenti, čtenářství, rodina, vliv rodinného prostředí, faktory ovlivňující čtenářstvíÚstav informačních studií a knihovnictvíInstitute of Information Studies and LibrarianshipFaculty of ArtsFilozofická fakult

Pragmatic licensing of Czech superstrong negative polarity items : an experimental study

In this study, we report an experiment focusing on pragmatic factors (unlikelihood presupposition) in licensing of Czech superstrong negative polarity items

Acquisition of polarity items in Czech children: An experimental study

The Czech polarity items i and ani are traditionally treated as English even. This paper deals with the acquisition of these polarity items in Czech children. These focus/scalar particles are specific for their sensitivity to probability. We aim to find out whether Czech children at primary school (junior school age) have already acquired i/ani and whether they are able to connect them correctly with alternatives on the scale of probability. The research was conducted with children from the second and the fourth grade at primary school. The paper represents an initial insight into this area since no similar research has been done in the Czech language so far.Linda Doleží: [email protected] Kurfürstová: [email protected] Šafratová: [email protected] Doleží is a language teacher and teacher trainer. She works as an Assistant Professor at Masaryk University Language Centre and at the Department of Czech Language of Faculty of Arts at Masaryk University. She focuses on teaching methodology, language acquisition and psycho- and neurolinguistics in multilingual contexts. Her current interests include language attrition phenomena and the role of emotions and trauma in language acquisition and attrition.Petra Kurfürstová is a graduate of upper secondary school teacher training in Czech language and literature at the Faculty of Arts at Masaryk University. In her M. A. thesis she dealt with the acquisition of scalar particles i and ani in Czech children. During her studies she was interested not only in child language acquisition and in teaching methodology but also in teaching Czech as a second language.Iveta Šafratová is a second-year doctoral student in a joint supervision of doctoral studies at the Department of Linguistics at Masaryk University and at the Seminar for English Philology at Georg-August-Universität Göttingen. She focuses on the syntaxsemantic- pragmatic interface and she is also interested in experimental linguistics. She is working on negation, especially scalar particles and polarity items in Czech.Linda Doleží - Masaryk UniversityPetra Kurfürstová - Masaryk UniversityIveta Šafratová - Masaryk University; Georg-August-Universität GöttingenCrnič, L. 2011. Getting Even [Unpublished PhD dissertation]. Massachusetts Institute of Technology.Doleží, L. 2014. Reduction and elaboration in Czech coordinate structures: An elicited imitation task. In: L. Veselovská & M. Janebová (eds.), Complex Visibles Out There. Proceedings of the Olomouc Linguistics Colloquium 2014: Language Use and Linguistic Structure, 387-400. Olomouc: Univerzita Palackého.Fox, D. & Hackl, M. 2006. The universal density of measurement. Linguistics and Philosophy 29(5): 537-586.Karttunen, L. & Karttunen, F. 1977. Even questions. In: NELS 7: Proceedings of the Seventh Annual Meeting of the North Eastern Linguistic Society, 115-34. Cambridge: MIT.Kim, S. 2011. Focus Particles at Syntactic, Semantic and Pragmatic Interfaces: The Acquisition of only and even in English [Unpublished PhD dissertation]. University of Hawaii at Manoa, Manoa.Krifka, M. 1995. The semantics and pragmatics of polarity items. Linguistic Analysis 25 (3-4): 209-57.Lamprecht, A., Šlosar, D. & Bauer, J. 1986. Historická mluvnice češtiny. Praha: Státní pedagogické nakladatelství.Mertins, B. et al. 2014. Identifikace konstituentů kompozit u předškolních dětí. Naše řeč 97(3): 146-165.Newman, E., Gowda, Y., Rosenstein, L. & Hackl, M. 2018. Polarity sensitivity of even in early child grammar. GALANA 8, Indiana University, Bloomington. Poster.Rámcový vzdělávací program pro základní vzdělávání [online]. Praha: MŠMT, 3-2017. Available from: http://www.nuv.cz/t/rvp-pro-zakladni-vzdelavani.Rooth, M. 1985. Association with Focus [Unpublished PhD dissertation]. University of Massachusetts.Saicová Římalová, L. 2013. Když začínáme mluvit... Lingvistický pohled na rané projevy česky hovořícího dítěte. Praha: Práce Filozofické fakulty Univerzity Karlovy, Varia.Sauerland, U. 2004. Scalar implicatures in complex sentences. Linguistics and Philosophy 27(3): 367-391.Smolík, F. & Bláhová, V. 2017. Comprehension of verb number morphemes in Czech children: Singular and plural show different relations to age and vocabulary. First Language 37(1): 42-57.Smolík, F. & Seidlová Málková, G. 2014. Vývoj jazykových schopností v předškolním věku. Praha: Grada.Spector, B. 2007. Scalar implicatures: Exhaustivity and Gricean reasoning. Questions in Dynamic Semantics 17: 225-249.Šafratová, I. 2018. Negation, NPI and Scales of Likelihood: An Experimental Study. [Unpublished Master’s thesis]. Masaryk University.Školní vzdělávací program pro základní vzdělání ZŠ a MŠ Rovečné. 2015. Rovečné.30 (3/2020)395

Advances in formal Slavic linguistics 2017

Advances in Formal Slavic Linguistics 2017 is a collection of fifteen articles that were prepared on the basis of talks given at the conference Formal Description of Slavic Languages 12.5, which was held on December 7-9, 2017, at the University of Nova Gorica. The volume covers a wide array of topics, such as control verbs, instrumental arguments, and perduratives in Russian, comparatives, negation, n-words, negative polarity items, and complementizer ellipsis in Czech, impersonal se-constructions and complementizer doubling in Slovenian, prosody and the morphology of multi-purpose suffixes in Serbo-Croatian, and indefinite numerals and the binding properties of dative arguments in Polish. Importantly, by exploring these phenomena in individual Slavic languages, the collection of articles in this volume makes a significant contribution to both Slavic linguistics and to linguistics in general

Advances in formal Slavic linguistics 2017

Advances in Formal Slavic Linguistics 2017 is a collection of fifteen articles that were prepared on the basis of talks given at the conference Formal Description of Slavic Languages 12.5, which was held on December 7-9, 2017, at the University of Nova Gorica. The volume covers a wide array of topics, such as control verbs, instrumental arguments, and perduratives in Russian, comparatives, negation, n-words, negative polarity items, and complementizer ellipsis in Czech, impersonal se-constructions and complementizer doubling in Slovenian, prosody and the morphology of multi-purpose suffixes in Serbo-Croatian, and indefinite numerals and the binding properties of dative arguments in Polish. Importantly, by exploring these phenomena in individual Slavic languages, the collection of articles in this volume makes a significant contribution to both Slavic linguistics and to linguistics in general

Advances in formal Slavic linguistics 2017

Advances in Formal Slavic Linguistics 2017 is a collection of fifteen articles that were prepared on the basis of talks given at the conference Formal Description of Slavic Languages 12.5, which was held on December 7-9, 2017, at the University of Nova Gorica. The volume covers a wide array of topics, such as control verbs, instrumental arguments, and perduratives in Russian, comparatives, negation, n-words, negative polarity items, and complementizer ellipsis in Czech, impersonal se-constructions and complementizer doubling in Slovenian, prosody and the morphology of multi-purpose suffixes in Serbo-Croatian, and indefinite numerals and the binding properties of dative arguments in Polish. Importantly, by exploring these phenomena in individual Slavic languages, the collection of articles in this volume makes a significant contribution to both Slavic linguistics and to linguistics in general

Advances in formal Slavic linguistics 2017

Advances in Formal Slavic Linguistics 2017 is a collection of fifteen articles that were prepared on the basis of talks given at the conference Formal Description of Slavic Languages 12.5, which was held on December 7-9, 2017, at the University of Nova Gorica. The volume covers a wide array of topics, such as control verbs, instrumental arguments, and perduratives in Russian, comparatives, negation, n-words, negative polarity items, and complementizer ellipsis in Czech, impersonal se-constructions and complementizer doubling in Slovenian, prosody and the morphology of multi-purpose suffixes in Serbo-Croatian, and indefinite numerals and the binding properties of dative arguments in Polish. Importantly, by exploring these phenomena in individual Slavic languages, the collection of articles in this volume makes a significant contribution to both Slavic linguistics and to linguistics in general

Advances in formal Slavic linguistics 2017

Advances in Formal Slavic Linguistics 2017 is a collection of fifteen articles that were prepared on the basis of talks given at the conference Formal Description of Slavic Languages 12.5, which was held on December 7-9, 2017, at the University of Nova Gorica. The volume covers a wide array of topics, such as control verbs, instrumental arguments, and perduratives in Russian, comparatives, negation, n-words, negative polarity items, and complementizer ellipsis in Czech, impersonal se-constructions and complementizer doubling in Slovenian, prosody and the morphology of multi-purpose suffixes in Serbo-Croatian, and indefinite numerals and the binding properties of dative arguments in Polish. Importantly, by exploring these phenomena in individual Slavic languages, the collection of articles in this volume makes a significant contribution to both Slavic linguistics and to linguistics in general