遵从抑或解释：公司环境信息披露研究综述

随着经济发展模式从更多地生产转向可持续生产，公司环境信息披露正成为重要的政策工具。当前的公司环境信息披露实践主要表现为自愿性披露，相关的理论主要分为强调解释性质的经济披露理论，以及强调遵从性质的社会政治理论两个流派。在此基础上，近年的实证研究集中在公司环境信息披露与公司环境绩效之间的关系、公司环境信息披露的经济后果等领域。通过对公司环境信息披露的起源、定义、方式、动因和后果进行系统综述，罗列代表性的观点和证据，从而对该领域的研究逻辑进行梳理，并提出评论和展望，以利于更好地理解自愿性公司环境信息披露行为，促进相关的制度设计和理论发展。国家自然科学基金面上项目“污染型企业环境信息披露与融资动机及其后果”(71272081);中央高校基本科研业务费专项资金资助项目(20720151184

Identification of Polygonatum from Wuyishan and Its Surrounding Areas by ISSR Molecular Markers and Their HPLC Fingerprints

采用ISSR分子标记鉴定方法及HPLC色谱方法对武夷山及周边地区5份黄精植物样本进行DNA分子标记鉴定及指纹图谱分析,并通过聚类分析软件分别探讨其遗传相关聚类图谱。ISSR分子标记法能较好地对5份黄精植物样本进行区分,HPLC指纹图谱分析同样表明5份黄精样本化学成分存在一定的差别。DNA分子标记及HPLC指纹图谱分析的遗传相关聚类分析结果相似,表明武夷山及周边地区的野生黄精种质资源存在明显的差别。The purpose of this project was to identify and analyze the genetic relationships of 5 kinds of Polygonatum in Wuyishan and its surrounding areas. Using ISSR marker and HPLC molecular identification method for chromatographic methods analysis of DNA markers for identification and fingerprinting of 5 Polygonatum samples, the genetic correlation map of Polygonatum was studied by cluster analysis software. ISSR molecular marker method could be used to distinguish Polygonatum of Wuyishan and its surrounding areas. HPLC fingerprint analysis also showed that there were some differences in the composition of Wuyishan and its surrounding distribution. The results of genetic correlation cluster analysis were similar by ISSR and HPLC. There were obvious differences in the germplasm resources of Wuyishan and its surrounding areas from the DNA molecular markers and HPLC fingerprinting analysis results.福建省科技厅自然科学基金重点项目（2013Y0018）;福建省科技厅自然科学基金青年项目（2015J01065

Effects of the Xitongxiao prescription on apoptosis and proliferation of chondrocytes in knee

目的：探讨膝痛消方对促进软骨细胞增殖和抑制IL-1β诱导的软骨细胞凋亡的作用。方法：体外培养膝关节软骨细胞，用阿利新蓝染色方法检测软骨细胞蛋白多糖，用Ⅱ型胶原免疫荧光染色检测软骨细胞Ⅱ型胶原的表达，以鉴定软骨细胞；用MTS检测软骨细胞的增殖；用IL-1β诱导软骨细胞凋亡，AnnexinV/PI双染检测细胞凋亡。结果：膝关节剥离得到的细胞形态为多角形或梭形，阿利新蓝与Ⅱ型胶原免疫荧光染色均呈阳性，证明分离培养的细胞为软骨细胞。MTS实验结果发现膝痛消方提取物处理软骨细胞后检测到的OD值随浓度增加而增加且显著高于对照组。此外，IL-1β处理诱导软骨细胞凋亡，而膝痛消方提取物能够有效地抑制IL-1β引起的细胞凋亡。结论：膝痛消方能促进软骨细胞的增殖，抑制IL-1β诱导的软骨细胞的凋亡。以上发现为膝痛消方临床上治疗膝关节骨性关节炎提供药理作用依据。Objective:To investigate the effects of the Xitongxiao prescription on the cell proliferation and the inhibition of IL-1β-induced apoptosis of chondrocytes.Methods:To identify chondrocytes,the articular chondrocytes were cultured in vitro;staining with alcian blue was used to detect the protein polysaccharide,and staining with collagen immunofluorescence was used to examine the expression of type II collagen in chondrocytes.The proliferation of chondrocytes was determined by MTS.Apoptosis of chondrocytes was induced by IL-1β,and the effect of apoptosis was tested by Annexin V/PI double staining.Results:The morphology of the cells obtained from the knee joint was polygonal or fusiform.The tested results of Alcian blue and collagen immunofluorescence staining were positive.These together certified that the isolated cells were knee chondrocytes.MTS assay results showed that the detected OD values were dosedependently increased and they were significantly higher than those of the control group.In addition,the apoptosis of chondrocytes was induced by IL-1βtreatment.While the extract of the Xitongxiao prescription could effectively inhibit the IL-1β-induced apoptosis of chondrocytes.Conclusion:The Xitongxiao prescription could promote the proliferation of chondrocytes and inhibit the apoptosis of chondrocytes induced by IL-1β.The above findings may provide one of pharmacological mechanisms of the Xitongxiao for clinical treatment of knee osteoarthritis.厦门市科技计划项目(3502z20144031);福建省自然科学基金计划资助项目(2015J01065)

温带荒漠中温度和土壤水分对土壤呼吸的影响

荒漠对气候变化具有高度敏感性,深刻认识和量化非生物因子对荒漠生态系统土壤呼吸的影响具有重要意义。采用自动CO2通量系统(Li-8100)监测了梭梭(Haloxylon ammodendron)、假木贼(Anabasis aphylla)和盐穗木(Halostachys caspica)群落生长季土壤呼吸及温度、土壤含水量等,深入分析了水热因子对土壤呼吸的影响。土壤呼吸具有不对称的日格局,最小值出现在8:00,最大值在12:00～14:00。土壤呼吸的季节格局与气温变化基本同步,最小值在生长季末期(10月),最大值在生长季中期(6～7月)。梭梭、假木贼和盐穗木群落生长季平均土壤呼吸速率分别为0.76、0.52和0.46μmol CO2·m-2·s-1。气温对假木贼(51%)和盐穗木群落(65%)土壤呼吸季节变化的解释率高于梭梭(35%)。梭梭、假木贼和盐穗木群落土壤呼吸温度敏感性(Q10)逐渐增大,基础呼吸速率(R10)逐渐减小。剔除温度影响后,梭梭、假木贼群落土壤呼吸与土壤含水量呈显著的幂二次方函数关系,盐穗木群落两者关系却明显减弱,未达到显著水平。气温、土壤含水量的二元方程均能解释群落土壤呼吸大部分的时间变异:梭梭群落71%～93%、假木贼群落79%～82%、盐穗木群落70%～80%。人工模拟降水后土壤呼吸速率表现出降水后10min减小、180min时明显增加、达到最大值后再次衰减的现象。5和2.5mm降水处理下的土壤呼吸速率最大值和其后的递减值高于对照处理,土壤呼吸增加、达到峰值和其后递减过程与5cm土壤温度变化基本同步

尼美舒利胶囊致体温过低1例

患者男,18岁,体重70 kg,既往体健,因“咳嗽、咽痛伴畏寒、发热4 d“为主诉于2015年1月25日就诊。既往史无特殊,无药物、食物过敏史。入院体检:T 40.2℃,P 82次/MIn,r 20次/MIn,bP 112/60 MM Hg。神志清楚,对答切题。口唇红润,伸舌居中,口腔黏膜无异常,双侧扁桃体Ⅱ度肿大,表面可见散在脓点,见白色分泌物,咽部后壁充血水肿,见淋巴滤泡,咽反射正常,余未见明显异常。血常规:WbC 14.99x109·l-1,n 76.4%,Hb 141 g·l-1,PlT 231x109·l-1;C反应

确保馆藏信息交流与转换的一致性—— 美国馆藏说明标准述评

美国馆藏说明标准历经近40年的发展，发展较为成熟且修订经验丰富，但其发展过程并非一帆风顺，历经新旧标准的更迭、 两个标准的统一、标准的多次修订及再确认这样一个复杂漫长的过程。拟以美国馆藏说明标准原始文本为基础，结合翻译过程中的扩展研究与思考，从美国馆藏说明标准的发展历史、主要内容和特点、与其他标准之间的关系及数据项和数据元四个方面进行系统的梳理与分析，以期为我国馆藏说明标准的完善提供有益参考。国家社科基金项目“中美电子资源国家标准比较研究”(项目编号:16BTQ027)研究成果之

我国高校涉密学位论文的管理现状与思考

随着高校科研创新能力的增强,涉密学位论文的数量有日渐增长的趋势。然而我国目前部分高校对涉密学位论文重视不够,尚未形成系统的管理细则,具体管理也不甚规范,这些都为高校知识产权问题埋下了隐患。因此,科学界定涉密学位论文的范围、完善涉密学位论文的提交、评审和答辩流程,加强对涉密学位论文保存的管理,是高校在知识产权时代的必然选择

White LED Phosphor Performance Tested by Spectro320e Spectrometer

我国lEd产业发展非常迅速,稀土钇铝石榴石(yAg)系列荧光粉广泛应用于白光lEd。德国InSTruMEnT SySTEMS公司的SPECTrO320E光谱仪适合光谱的精确测量,文章结合SPECTrO320E和远方公司的PE-5荧光粉激发装置,实现蓝光激发下黄色yAg荧光粉的色品坐标、相对亮度、量子效率等参数精确的测试,研究了仪器在不同的测试条件如暗电流、光电倍增管、密度滤光片等设置的不同,对测试结果的影响,并给出利用本装置测试荧光粉时应该注意的事项。LED industry in china develops rapidly.Yttrium aluminitum garnet(YAG) phosphors are widely applied in white LEDs.The Instrument Systems company's Spectro320e spectrometer is suitable for accurate measurement of the spectrum.It is combined in this paper with the Everfine company's PE-5 phosphor excitation device to achieve the accurate testing of yellow YAG phosphors excited by blue light,such as chromaticity coordinates,relative brightness and quantum efficiency.We also studied the influence of different testing conditions on the results,such as dark current,PMT and density filter.The cautions are provided herewhen using the Spectro320e spectrometer

普鲁兰基肿瘤靶向性纳米粒子的制备、稳定性和体外释放

背景:普鲁兰多糖以其独特的优点在纳米递药系统领域受到越来越多的关注,但是,以普鲁兰多糖为材料进行改性制备的肿瘤靶向的纳米药物载体仍有待进一步研究与开发。目的:观察纳米粒子和载药纳米粒子的体外稳定性及所包载药物的释放特征,初步评价其作为纳米药物载体的潜力。方法:应用透析法制备乙酰普鲁兰叶酸偶合体纳米粒子,以表阿霉素为模型药物,制备乙酰普鲁兰叶酸偶合体/表阿霉素载药纳米粒子(FPA/EPI),应用储存法考察其稳定性,应用透析袋法观测体外释放特征。结果与结论:乙酰普鲁兰叶酸偶合体纳米粒子和FPA/EPI的粒径分别为(204.2±10.9)nm和(273.4±11.0)nm,在蒸馏水和体积分数10%胎牛血清中表面电位均较低,乙酰普鲁兰叶酸偶合体纳米粒子在水溶液中粒径1年内未见显著改变。载药纳米粒子对所包载的药物表阿霉素进行很好地释放,pH5.0磷酸盐缓冲液中释放速度明显高于pH7.4;乙酰普鲁兰叶酸偶合体纳米粒子和FPA/EPI制备容易,稳定性好,初步说明了两种粒子可望成为新型肿瘤靶向药物递药系统

Preparation of self-assembled cholesterol modified pullulan nanopaticles

的:经琥珀酸间隔臂将胆甾醇连接到普鲁兰分子链上,对普鲁兰多糖进行疏水改性,获得不同取代度的胆甾醇基-普鲁兰(cholesterol-modified pullulan,CHSP)改性材料,并研究CHSP材料在水中的自组装性质。方法:利用1-乙基-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐(EDC)和4-二甲氨基吡啶(DMAP)催化琥珀酰胆甾醇(cholesterol succinate,CHS)与普鲁兰多糖反应,将琥珀酰胆甾醇接枝在普鲁兰分子链的羟基上,得到疏水改性的普鲁兰多糖衍生物。应用傅立叶红外光谱仪(Fourier transform infrared spectroscopy,FT-IR),核磁共振仪(proton nuclear magnetic resonance,1H-NMR)对产物进行表征。利用透析法制备自组装纳米球。通过透射电镜(transmission electron microscopy,TEM),动态激光粒度分析仪(dynamic laser lightscattering,DLS)表征了纳米粒的形态和粒径。以芘为荧光探针,通过荧光检测分析,测定CHSP的临界胶束浓度(critical... 【英文摘要】 Objective:To synthesize cholesterol-modified pullulan(CHSP) conjugates and to preparate self-assembled nanoparticles.Methods:The cholesterol-modified pullulan(CHSP) was prepared by the reaction of pullulan and cholesterol succinate(CHS) in DMSO,using EDC and DMAP as catalysts.The polymer structure was confirmed by the Fourier transform infrared spectroscopy(FT-IR) and proton nuclear magnetic resonance(1H-NMR).The self-assembled nanoparticles were analyzed by transmission electron microscopy(TEM),dynamic las...国家重大科学研究计划项目(2006CB933300);; 博士点基金(20060023050