The study for schizophrenia patients of multi-disciplinary team in community rehabilitation services—take assertive community treatment in S.N, as an example

精神卫生既是公共卫生问题，也是重大的社会问题。中国内地共有严重精神障碍患者1600万人，精神分裂症患者780万人，其中90%的精神分裂症患者生活在社区，我国精神卫生服务模式正从单纯的医学模式向生理—心理—社会综合模式转变，建立多学科服务团队回应患者及家属的多元需求正在被越来越多的人推崇和认可。主动式社区治疗模式是一种应用于精神分裂症患者的社区照顾模式，该模式通过组建包括社工、精神卫生科医生、心理咨询师和护士等在内的多学科团队，帮助精神障碍患者逐渐恢复独立生活的能力，降低患者住院率，促进患者融入社区和社会。S市N区主动式社区治疗项目已运行4年，本研究拟通过主动式社区治疗项目研究多学科服务团队介入...Mental health problem is a public health problem and significant social problem. The chinese mainland have a total of 16 million patients with severe mental disorders,7.8 million patients with schizophrenia,90% of them live in community. In china, mental health service model is from the biomedical mode to the biological-psychology-social medical model, establish a multi-disciplinary service team b...学位：社会工作硕士院系专业：公共事务学院_社会工作硕士学号：1402014115052

Long-term Accompanying Service：Reflection on the Specialization in Social Work

自2006年以来,中国专业社会工作经历了快速发展的10年,一方面专业服务的范围和领域不断扩展;另一方面服务专业性的困惑和理论诉求越来越明显,尤其精神病人社区康复服务领域,这一矛盾更为突出。本研究跟踪深圳市南山区慢性病防治院的主动式社区治疗,这种访视社区重性精神病人的长期陪伴服务,发现：1.长期陪伴服务具有时间跨度较长、场景特征明显、服务焦点生活化、服务方式综合化和服务关系朋友化的特点,与专业推崇的目标清晰、成效明显的短期聚焦服务不同;2.长期陪伴服务是关注服务对象日常生活技能提升和社会歧视消除的场景服务,有自己的专业要求,是另一种专业的社会工作服务;3.中国本土专业社会工作采取的是试点推进的场景服务,作为场景服务的典型代表——长期陪伴服务,是本土社会工作成就自身专业性的最好方式。本研究的结论有利于本土社会工作者反思专业服务的标准,拓宽专业服务的视野。Since 2006,China is undergoing a rapid growth in social work. In contrast with the rapid expansion of thescopes and fields for social work,the need for specialization in social work is creasing. Especially in mental health service in community,this demand is even higher. This article is intended to study a project on mental health in community called Assertive community treatment carried out in Shenzhen for 4 years,and finds that： 1. the longstanding accompanying service is different from the short-term services; 2. the longstanding accompanying service is another kind of specialized social work; 3. the longstanding accompanying service is the best way for Chinese social workers to promote specialization of social work.国家社会科学基金重点项目《中国特色现代社会福利体系建构研究》（15ASH008）;深圳市南山区精神卫生社区康复（多学科主动式社区治疗项目）创新提升项

基于培养基压力控制的组织工程化生物膜动态培养系统的研究

目的研究压力大小可控的培养系统,以实现组织工程化生物膜的动态培养。方法根据帕斯卡定律的基本原理,设计培养基压力的控制方法,建立由培养皿、蠕动泵、压力控制模块、主控器与检测模块等组成的组织工程化生物膜动态培养系统。结果该系统可实现培养基于0.12～19.76 mmHg压力范围内的控制。结论该系统为适宜压力范围内的生物膜培养提供所需的压力环境,为组织工程化生物膜动态培养技术提供新思路

Study on HPLC Fingerprint of Chinese Marine Medicine Dried Scallop

目的建立海洋中药干贝高效液相色谱(HPlC)指纹图谱分析方法 ,为其质量控制和药材鉴别提供依据。方法采用反相AllTIMA-C18柱,水(A)和乙腈(b)为流动相,梯度洗脱,流速为0.8Ml/MIn,检测波长210nM,柱温20℃,进样体积30μl;采用高效液相色谱二极管阵列检测器-质谱联用技术(HPlC-dAd-MS)对其特征峰进行快速分析;采用相似度计算软件用于10批干贝药材的相似度评价。结果初步建立了干贝药材的HPlC指纹图谱,10批干贝药材指纹图谱有9个共有峰,相似度均在0.85以上;HPlC-dAd-MS分析获得的4个特征峰的紫外光谱和质谱信息,可用于干贝药材指纹图谱特征峰以及共有峰的准确确定。结论该方法准确、简单、稳定性好,为干贝药材的真伪鉴别及质量控制提供了科学依据。Objective To establish a chromatographic fingerprint of Dried Scallop,a kind of Chinese marine medicine,by high performance liquid chromatography (HPLC),and apply for quality assessment and control of medicine materials of Dried Scallop.Methods Separation was performed on an Alltima-C18 (250 mm × 4.6 mm,5μm),with mobile phase consisting of water (A) and acetonitrile (B) with gradient elution at the flow rate of 0.8 ml/min.The UV detection wavelength was 210 nm,column temperature was 20℃.Characteristic peaks of the fingerprint could be rapidly analyzed by high performance liquid chromatography-mass spectrometry (HPLC-MS),and the software of similarity analysis was used to calculate the similarity of all the Dried Scallop samples.Results All samples tested contained the same nine peaks,and the similarities of 10 batches of Dried Scallop were more than 0.85.MS and UV spectra of the 4 characteristic peaks obtained using HPLC-MS could be used to accurately confirm the characteristic and common peaks in fingerprint of Dried Scallop.Conclusion This method is simple,accurate and stable,and can provide scientific reference for the identification and quality control of Dried Scallop.国家自然科学基金(No.20602009;20905017);海洋公益性行业科研专项(No.200705011;200805039

Identification of Bohai Sea crude oil based on characteristic fingerprinting by MSPD-RP-HPLC

建立渤海原油的高效液相色谱(HPlC)特征指纹图谱,为渤海原油的鉴别提供一种新方法。以氧化铝作为基质固相分散剂进行样品处理,采用HPlC法进行分析,双反相C18色谱柱串联,以乙腈-水为流动相,二元线性梯度洗脱,流速为1.0 Ml/MIn,柱温为20℃,双波长检测226 nM、254 nM,进样量10μl;采用所发展的方法对10批渤海原油样品进行分析,建立渤海原油的HPlC特征指纹图谱,结合相似度分析用于渤海原油的鉴别。该方法具有很好的精密度、重复性和稳定性,10批渤海原油特征指纹图谱有13个共有峰,结合相似度分析可以用于渤海原油样品的鉴别,说明HPlC特征指纹图谱是渤海原油鉴别的有力工具。Based on the high performance liquid chromatography(HPLC) characteristic fingerprinting,a new method for crude oil identification of Bohai Sea was developed.The sample pretreatment was done using matrix solid-phase dispersion,and Al2O3 was used as the dispersant.The chromatographic fingerprints were determined by injecting 10 L sample solution each time on two reverse phase C18 columns in series with the gradient elution solvent system composed of water and acetonitrile.The flow rate was 1.0 mL/min,the column temperature was maintained at 20℃ and the signals were acquired at 226 nm and 254 nm.The characteristic fingerprints of crude oil were established by analysis of ten representative samples derived from Bohai Sea,and identification was carried out by the similarity analysis of the characteristic fingerprints.The method was ideally suited for the fingerprinting of Bohai Sea crude oil with good precision,repeatability and stability.13 peaks were selected as the common peaks of the characteristic fingerprint and used for the similarity analysis,which could be applied to distinguish crude oil of Bohai Sea from that of other sources.The characteristic HPLC fingerprinting technique thus was a powerful tool for the identification of crude oil originated from Bohai Sea.海洋公益性行业科研专项(200705011;201005034-3);中国海监技术支撑体系项目;2008年海洋环境保护及节能减排专

Simultaneous determination of 7 nucleosides in Asterias rollestoni using reversed-phase high performance liquid chromatography

建立了罗氏海盘车中7种核苷化合物的反相高效液相色谱分析测定方法。采用超声波辅助提取,选用两根不同的C18色谱柱串联,以甲醇和0.2%(体积分数)乙酸/水溶液为流动相梯度洗脱分离。优化的色谱条件为:柱温为室温,检测波长为260nM,流速为0.8Ml/MIn,进样量为20μl。结果表明,7种核苷化合物在一定的浓度范围内线性关系良好,次黄嘌呤和胸苷的线性范围为0.65~40Mg/l,尿苷、黄嘌呤和肌苷的线性范围为0.80~40Mg/l,胸腺嘧啶的线性范围为1.15~40Mg/l,鸟苷的线性范围为0.50~40Mg/l。样品中7种核苷化合物的加标回收率为90.00%~105.00%,相对标准偏差为0.72%~3.23%。该方法操作简便、灵敏度高、重复性好,回收率高,适用于罗氏海盘车中7种核苷类成分的同时分析,也可用于罗氏海盘车的质量控制和综合评价。A method for the simultaneous determination of 7 nucleosides in Asterias rollestoni was devel-oped using reversed-phase high performance liquid chromatography ( RP-HPLC) .Analytes were extracted by ultrasonic-assisted extraction and separated on two different C18 columns,which were connected in se-ries,under the gradient elution with the mobile phases of methanol and 0.2% ( v/v) acetic acid/water at room temperature.The chromatographic conditions were as follows: flow rate,0.8 mL/min; detection wavelength,260 nm; injection volume,20 μL.Under the optimized conditions,good linear relationships between the values of mass concentrations and the peak areas of hypoxanthine,uridine,xanthine,thy-mine,inosine,guanosine and thymidine were observed in the ranges of 0.65-40,0.80-40,0.80-40,1.15-40,0.80-40,0.50-40,and 0.65-40 mg/L,respectively.The relative standard devia-tions were around 0.72%-3.23% and the recoveries were around 90.00%-105.00%.The results showed that the developed method is sensitive,accurate and reproducible.It is suitable for the analysis of nucleosides in Asterias rollestoni with high recoveries and it is expected to be used for the quality control and evaluation of Asterias rollestoni.国家自然科学基金项目(20905017);海洋公益性行业科研专项(200705011;200805039);海洋局青年基金项目(2010140);海洋一所基本科研业务专项(GY-022008T32;2010G25);中国科学院实验海洋生物学重点实验室开放基金课

Determination of five poisonous elements in holothurian sold on the market by Microwave Digestion with ICP—MS

建立了微波消解—电感耦合等离子体质谱法测定海参中Cu,AS,Cd,Hg,Pb 5种有毒元素含量的方法,采用In元素为内标,利用其回收率对以上5种元素的测定结果进行校正,该方法变异系数(CV%)为0.2%--4.0%,In元素加标回收率为96.7%--104.5%,说明该方法灵敏度高,结果准确可信。利用该方法对10批不同市售海参中5种有毒元素含量进行了测定,结果表明10批市售海参中的AS含量均超标,部分批次海参中的Cd、Pb超标,说明市售海参确实存在有毒元素超标的问题。A method based on microwave sample digestion and inductively coupled plasma-mass spectrometry(ICP—MS) detection was established for determination of Cu,As,Cd,Hg and Pb in holothurian sold on the market.Indium was used as internal standard element to calibrate the results of determination of these five elements.Determination limits of these five elements were in the range of 0.006～0.063 μg/g,coefficient of variation(CV%)were in the range of 0.2%～4.0%,and the recovery of In was in the range of 96.7%～104.5%.The method has been applied to determine the five poisonous elements in ten holothurian samples sold on the market.The results indicated that the over-standard problem of poisonous elements in holothurian sold on the market existed.The content of total arsenic was over standard in all the ten samples,but the over standard problem of lead and cadmium was only found in part of the samples.国家自然科学基金(20675021);中国近海海洋综合调查与评价908专项(908-02-05-04)资

Primary Exploration on Quality Evaluation of Holothurian Sold on the Market by HPLC Fingerprint

以10批不同产地刺参HPlC指纹图谱中的6个共有峰为评价指标,结合相似度分析,对不同刺参质量进行评价和检验。结果表明:不同批次刺参样品的6个色谱峰在指纹图谱分析过程中色谱行为相同,峰面积大,特征性强,能反映刺参的固有化学特征。结合相似度分析,可用于刺参质量评价。An optimized high performance liquid chromatography (HPLC) method was developed for the analysis of holothurian and the HPLC fingerprint was established from 10 batches of the holothurians from different habitats.The HPLC fingerprint showing 6 common characteristic peaks was used to explore the quality evaluation of holothurian and distinguish from the fakes with the similarity analysis.This method is accurate and reliable,providing a scientific basis for the quality control of holothurian and can be used to evaluate the quality of holothurian sold on the market.我国近海海洋综合调查与评价908专项(908-02-05-04):海洋药用生物资源评价和《中华海洋本草》编纂;海洋一所基本科研业务专项(GY-022008T32):海洋绿藻活性成分分析、鉴

利用同一土柱测定土壤水分和保守性溶质运移参数

利用数学模型预测土壤水分和溶质运移过程的准确性取决于所涉及的水力参数和土壤溶质运移参数的可靠性和精度。目前由于实验系统和研究方法的限制,在测定水力参数和溶质运移参数时所采用的土壤样本不一致,产生了样本误差。本文建立了利用同一土壤样本测定水力参数和溶质运移参数方法,即首先进行水平一维入渗实验,待土壤饱和后改换为供溶液试验,测定土壤边界层随时间的变化过程从而计算出溶质运移参数。与传统的利用土壤溶质穿透曲线获得参数的方法比较表明,本文提出的方法是可行的

科研机构引进电子资源科技支撑绩效评价研究与发展--以中国科学院集团引进外文电子期刊为例

介绍中国科学院文献情报中心在电子资源科技支撑绩效评价领域开展的工作以及取得的阶段性成果，为科研机构开展电子资源科技支撑绩效评价提供有益参考。结合国内外电子资源成效评估的理论与实践，构建以外文电子期刊为案例的电子资源科技支撑绩效评价指标体系，并进行实例评价；同时，根据研究所的科技支撑绩效评价需求，补充和完善面向研究所评价目的的电子资源科技支撑绩效评价指标体系。通过实例评价，构建的外文电子期刊科技支撑绩效指标体系具有可操作性；同时，融合研究所的评价需求，改造构建形成了满足集团牵头单位和研究所评价需求的外文电子期刊科技支撑评价指标体系。</p