Neighborhood Support and Children's Connectedness

Summarizes research on the links between levels of neighborhood support, such as neighbors helping one another, and other types of "connectedness" that contribute to children's healthy development -- with family, peers, community, and activities

A molecular and in vivo investigation of advanced prostate cancer: Deconstructing AMPK activity and developing an improved mouse model

Prostate cancer is one of the leading causes of cancer-related death in men. Prostate cancer is dependent on androgen receptor (AR)-mediated pathways, and AR is therefore targeted to treat advanced prostate cancer. Despite an initial response to current AR-targeted therapies, patients invariably relapse, due in large part to the reactivation of AR through a variety of mechanisms. My goal is to identify pathways downstream of AR that can be therapeutically targeted. We and others previously demonstrated that in prostate cancer, calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is a direct downstream target of AR, and can promote disease progression through the phosphorylation and activation of the 5’ AMP activated protein kinase (AMPK). AMPK is a major regulator of cell homeostasis. While it is well established that AMPK is required for processes like cell growth, development, and stress response, its role in cancer is enigmatic. AMPK can promote both oncogenic and tumor suppressive pathways in different contexts, making it challenging to target for cancer drug development. Interestingly, the α1 and α2 isoforms of the catalytic α subunit of AMPK have been shown to localize to distinct compartments within the cell, and molecular studies indicate that these isoforms have non-redundant functions. Furthermore, subcellular populations of AMPK behave differently in response to stress. Together, these findings suggest that separate populations of AMPK within the cell may behave differently, challenging the dogma of AMPK existing as a single signaling molecule. In the advanced stages of prostate cancer, the cancer spreads to local and distant lymph nodes and other organs. Prostate cancer metastasizes primarily to bone, with up to 90% of men who die of prostate cancer having bone metastases upon autopsy. A major limitation in the study of advanced prostate cancer is a lack of relevant preclinical models of disease progression. Rodents are the most commonly used animal models for studying prostate cancer, and many mouse models have been developed and are widely used in prostate cancer research. However, these models typically fail to recapitulate the full progression of prostate cancer in humans. In fact, there are currently no prostate cancer mouse models that reliably produce bone metastases at a similar rate to human disease. Given this issue, I sought to develop a tractable model of mouse prostate cancer metastasis that consistently metastasizes from the primary site to bone, as it does in human disease

Explanation classification depends on understanding: extending the epistemic side-effect effect

Our goal in this paper is to experimentally investigate whether folk conceptions of explanation are psychologistic. In particular, are people more likely to classify speech acts as explanations when they cause understanding in their recipient? The empirical evidence that we present suggests this is so. Using the side-effect effect as a marker of mental state ascriptions, we argue that lay judgments of explanatory status are mediated by judgments of a speaker’s and/or audience’s mental states. First, we show that attributions of both understanding and explanation exhibit a side-effect effect. Next, we show that when the speaker’s and audience’s level of understanding is stipulated, the explanation side-effect effect goes away entirely. These results not only extend the side-effect effect to attributions of understanding, they also suggest that attributions of explanation exhibit a side-effect effect because they depend upon attributions of understanding, supporting the idea that folk conceptions of explanation are psychologistic

Development of electrical test procedures for qualification of spacecraft against EID. Volume 2: Review and specification of test procedures

A combined experimental and analytical program to develop system electrical test procedures for the qualification of spacecraft against damage produced by space-electron-induced discharges (EID) occurring on spacecraft dielectric outer surfaces is described. A review and critical evaluation of possible approaches to qualify spacecraft against space electron-induced discharges (EID) is presented. A variety of possible schemes to simulate EID electromagnetic effects produced in spacecraft was studied. These techniques form the principal element of a provisional, recommended set of test procedures for the EID qualification spacecraft. Significant gaps in our knowledge about EID which impact the final specification of an electrical test to qualify spacecraft against EID are also identified

Ethnic Conflict: An Organizational Perspective

To talk about the behavior of others is to generalize especially if that behavior is perceived to be negative. As researchers who have studied ethnic discrimination and ethnic conflict for close to two decades, we have noticed, anecdotally at least, that this penchant for generalization is rampant in discussions of ethnic politics. Journalists and academics tend to talk about one or another ethnic group’s involvement in violence without specifying a political organizational agent. This kind of generalization is a serious obstacle to understanding conflicts and identifying solutions because it prevents policymakers and academics from getting at the messy reality of ethnic politics—especially when they become contentious or violent. This article explores how organizations often change their policies and shift back and forth between violent and nonviolent strategies, occasionally adopting both at the same time. In the process, this article provides a counter-balance to generally accepted wisdom concerning the relationship between ethnicity and conflict

Explanation classification depends on understanding: extending the epistemic side-effect effect

Our goal in this paper is to experimentally investigate whether folk conceptions of explanation are psychologistic. In particular, are people more likely to classify speech acts as explanations when they cause understanding in their recipient? The empirical evidence that we present suggests this is so. Using the side-effect effect as a marker of mental state ascriptions, we argue that lay judgments of explanatory status are mediated by judgments of a speaker’s and/or audience’s mental states. First, we show that attributions of both understanding and explanation exhibit a side-effect effect. Next, we show that when the speaker’s and audience’s level of understanding is stipulated, the explanation side-effect effect goes away entirely. These results not only extend the side-effect effect to attributions of understanding, they also suggest that attributions of explanation exhibit a side-effect effect because they depend upon attributions of understanding, supporting the idea that folk conceptions of explanation are psychologistic

Explanation classification depends on understanding: extending the epistemic side-effect effect

Our goal in this paper is to experimentally investigate whether folk conceptions of explanation are psychologistic. In particular, are people more likely to classify speech acts as explanations when they cause understanding in their recipient? The empirical evidence that we present suggests this is so. Using the side-effect effect as a marker of mental state ascriptions, we argue that lay judgments of explanatory status are mediated by judgments of a speaker’s and/or audience’s mental states. First, we show that attributions of both understanding and explanation exhibit a side-effect effect. Next, we show that when the speaker’s and audience’s level of understanding is stipulated, the explanation side-effect effect goes away entirely. These results not only extend the side-effect effect to attributions of understanding, they also suggest that attributions of explanation exhibit a side-effect effect because they depend upon attributions of understanding, supporting the idea that folk conceptions of explanation are psychologistic