Resistance: An Arendtian Reading of Solidarity and Friendship in Foucault

Recent scholarship has firmly established the similarities between Arendt and Foucault, in particular with regard to the dangers of late-modern social processes. Yet, few have compared their accounts of resistance. This paper argues that although Foucault offers the more comprehensive account, it omits the encounter with the other as unique and unfathomable, which is central to Arendt’s. This omission is particularly striking given the authors’ shared belief that the danger of ‘the social’ and ‘governmentality’ lies in atomizing individuals and barring the development of a singular style of being, and their allusion to friendship and solidarity as sites of resistance. Drawing on Arendt, I show how Foucault restricts his thematization of solidarity and friendship to a reflexive praxis of the subject on her own limits, and argue instead for the relational dimension of resistance. I start by reconstructing their converging analysis of biological racism. I then continue with a discussion of resistance in Arendt, which she develops in response to the Shoah. More specifically, she provides a concept of solidarity and friendship that I draw on to extend Foucault’s analysis of the transnational solidarity among the governed in fighting for their rights vis-à-vis their governments; and of friendship in the context of his interrogation of the LGBT-movement

Barley 14-3-3 Biology

Lill, H. [Promotor]Boer, A.H. de [Copromotor

The description of names in the Vroegmiddelnederlands Woordenboek

The Vroegmiddelnederlands Woordenboek (Dictionary of Early Middle Dutch) is a perioddictionary, based on historical principles, which will describe the Dutch stock of words recorded in the 13th century. In this dictionary the onomastic material is completely incorporated into the articles. By means of various examples I will show in what way the !3th-century ftrst names, surnames and geographical names are handled in the dictionary and what kind of information they add to it

Are you connected?: A network perspective on cognitive dysfunction in early multiple sclerosis

Barkhof, F. [Promotor]Geurts, J.J.G. [Promotor]Polman, C.H. [Copromotor]Vrenken, H. [Copromotor

Agreement of MSmetrix with established methods for measuring cross-sectional and longitudinal brain atrophy

Introduction Despite the recognized importance of atrophy in multiple sclerosis (MS), methods for its quantification have been mostly restricted to the research domain. Recently, a CE labelled and FDA approved MS-specific atrophy quantification method, MSmetrix, has become commercially available. Here we perform a validation of MSmetrix against established methods in simulated and in vivo MRI data. Methods Whole-brain and gray matter (GM) volume were measured with the cross-sectional pipeline of MSmetrix and compared to the outcomes of FreeSurfer (cross-sectional pipeline), SIENAX and SPM. For this comparison we investigated 20 simulated brain images, as well as in vivo data from 100 MS patients and 20 matched healthy controls. In fifty of the MS patients a second time point was available. In this subgroup, we additionally analyzed the whole-brain and GM volume change using the longitudinal pipeline of MSmetrix and compared the results with those of FreeSurfer (longitudinal pipeline) and SIENA. Results In the simulated data, SIENAX displayed the smallest average deviation compared with the reference whole-brain volume (+ 19.56 ± 10.34 mL), followed by MSmetrix (− 38.15 ± 17.77 mL), SPM (− 42.99 ± 17.12 mL) and FreeSurfer (− 78.51 ± 12.68 mL). A similar pattern was seen in vivo. Among the cross-sectional methods, Deming regression analyses revealed proportional errors particularly in MSmetrix and SPM. The mean difference percentage brain volume change (PBVC) was lowest between longitudinal MSmetrix and SIENA (+ 0.16 ± 0.91%). A strong proportional error was present between longitudinal percentage gray matter volume change (PGVC) measures of MSmetrix and FreeSurfer (slope = 2.48). All longitudinal methods were sensitive to the MRI hardware upgrade that occurred during the time of the study. Conclusion MSmetrix, FreeSurfer, FSL and SPM show differences in atrophy measurements, even at the whole-brain level, that are large compared to typical atrophy rates observed in MS. Especially striking are the proportional errors between methods. Cross-sectional MSmetrix behaved similarly to SPM, both in terms of mean volume difference as well as proportional error. Longitudinal MSmetrix behaved most similar to SIENA. Our results indicate that brain volume measurement and normalization from T1-weighted images remains an unsolved problem that requires much more attention

An affective disorder in zebrafish with mutation of the glucocorticoid receptor

Upon binding of cortisol, the glucocorticoid receptor (GR) regulates the transcription of specific target genes, including those that encode the stress hormones corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone. Dysregulation of the stress axis is a hallmark of major depression in human patients. However, it is still unclear how glucocorticoid signaling is linked to affective disorders. We identified an adult-viable zebrafish mutant in which the negative feedback on the stress response is disrupted, due to abolition of all transcriptional activity of GR. As a consequence, cortisol is elevated, but unable to signal through GR. When placed into an unfamiliar aquarium ('novel tank'), mutant fish become immobile ('freeze'), show reduced exploratory behavior and do not habituate to this stressor upon repeated exposure. Addition of the antidepressant fluoxetine to the holding water and social interactions restore normal behavior, followed by a delayed correction of cortisol levels. Fluoxetine does not affect the overall transcription of CRH, the mineralocorticoid receptor (MR), the serotonin transporter (Serta) or GR itself. Fluoxetine, however, suppresses the stress-induced upregulation of MR and Serta in both wild-type fish and mutants. Our studies show a conserved, protective function of glucocorticoid signaling in the regulation of emotional behavior and reveal novel molecular aspects of how chronic stress impacts vertebrate brain physiology and behavior. Importantly, the zebrafish model opens up the possibility of high-throughput drug screens in search of new classes of antidepressants