An Electrically Programmable Split-Electrode Charge-Coupled Transversal Filter (EPSEF)

A CCD split-electrode transversal filter (EPSEF) with analog controlled tap weights is described. The programmable tap weighting utilizes a novel analog multiplier for sampled data, based on charge profiling underneath a resistive gate structure. The EPSEF device concept and the performance data of a prototype filter with eight programmable taps are presented. Applications of the EPSEF in several programmed filter functions and in an adaptive filter system are demonstrated

Introduction:Settler Colonies Between Roman Colonial Utopia and Modern Colonial Practice

This chapter shows the relevance of Carlo Sigionio’s reconstruction of Roman colonial practices for the history and theory of settler colonialism. It discusses how Sigonio’s analysis of Roman colonization as a vehicle of social emancipation implicitly criticized Venetian colonial strategies in the Eastern Mediterranean, and sketches its impact on European visions of overseas colonialism in the seventeenth and eighteenth centuries, highlighting English and Dutch examples of settler colonialism between Batavia (Jakarta) and Savannah, Georgia. For Sigonio, the Roman colony could be characterized as a well-ordered agrarian landscape concerned with protecting the property claims and political rights of a clearly defined community of citizen–farmers. With his detailed study of Roman colonial law and practice, Sigonio showed that there was a historical foundation for settler colonialism to work effectively. His reconstruction of the Roman settler colony made it possible to conceive of a colonial utopia as a concrete colonial practice

Colonial landscapes : demography, settlement organization and impact of colonies founded by Rome (4th-2nd centuries BC)

In conventional models, the Roman colonial countryside has been characterized as consisting of rigid systems of land division and a dense network of isolated, mono-nuclear peasant farms which were situated at regular intervals from each other. Yet, the evidence on which the conventional model of colonial settlement organization is based is very fragile. This book, therefore, critically re-examines the traditional understanding of colonial rural organization, focusing especially on issues of population density, land division, settlement organization and geo-political arrangements.LEI Universiteit LeidenThis programme was funded by the Netherlands Organisation for Scientific Research (NWO). I received additional funding from the Royal Netherlands Institute in Rome (KNIR) and from the Leiden University Fund (LUF).The Unification of the Mediterranean World (400 BC - 400 AD

A Framework for Evaluating Security in the Presence of Signal Injection Attacks

Sensors are embedded in security-critical applications from medical devices to nuclear power plants, but their outputs can be spoofed through electromagnetic and other types of signals transmitted by attackers at a distance. To address the lack of a unifying framework for evaluating the effects of such transmissions, we introduce a system and threat model for signal injection attacks. We further define the concepts of existential, selective, and universal security, which address attacker goals from mere disruptions of the sensor readings to precise waveform injections. Moreover, we introduce an algorithm which allows circuit designers to concretely calculate the security level of real systems. Finally, we apply our definitions and algorithm in practice using measurements of injections against a smartphone microphone, and analyze the demodulation characteristics of commercial Analog-to-Digital Converters (ADCs). Overall, our work highlights the importance of evaluating the susceptibility of systems against signal injection attacks, and introduces both the terminology and the methodology to do so.Comment: This article is the extended technical report version of the paper presented at ESORICS 2019, 24th European Symposium on Research in Computer Security (ESORICS), Luxembourg, Luxembourg, September 201

Surface visibility and the validity of settlement patterns in legacy survey datasets

The ground visibility of the terrain that is surveyed has a clear impact on detecting archaeological finds. Because the resulting distortions may influence the quality of the interpretation of single settlements and settlement patterns, various checks of the terrain and the collected data are needed. Therefore, in current survey projects different types of tests and data filtering are increasingly implemented both in the field and in the laboratory as a part of their methodology. However, some of the most important archaeological landscape projects were initiated long before an agreement on a standard methodology for field survey was reached. As a result, legacy datasets have been deemed to be of little value to present-day scholarship due to the current research standards. In this paper, we examine if legacy data can be useful to contemporary research by performing a study comparing legacy data collected by the Forma Italiae survey project to contemporary data collected by the LERC project. The Forma Italiae survey project was carried out in the late 20th century and produced a large dataset of archaeological sites in the area around the ancient town of Venusia (located in Southern Italy). We first analyzed the relationship between surface visibility and the density of identified Hellenistic-period sites by means of a statistical analysis, and then tested the reliability of the legacy site patterns by comparing them with new data recovered from the field in a recent re-survey of this region by our team as a part of the LERC project. We thus assessed the compatibility of the clustered pattern of sites detected by the Forma Italiae and the new LERC field surveys. At odds with more pessimistic estimations, we conclude that on the regional level and coarse scale of analysis the legacy survey data is representative and offers significant evidence to current scholarship for the study of ancient settlement patterns.This article is the revised version of a chapter in a PhD thesis (CASAROTTO 2018: 91-103) conducted in the framework of the Landscapes of Early Roman Colonization project (NWO project 360-61-040, Leiden University, KNIR).Peer reviewe

Role of metabolic pathways and sensors in regulation of dendritic cell-driven T cell responses

Dendritic cells are the canonical professional antigen-presenting cell and are therefore crucial in the generation of efficient adaptive T cell responses. It is now well described that immune cells – including dendritic cells – make drastic changes to their biology to transition between different life stages and to deal efficiently with the threat of infection. However, an unanswered question was if DCs with different T cell polarizing properties - that is to say they preferentially skew T cells towards a specific specialization (for example T helper 1 cells over T helper 2 cells) - rely on distinct metabolic characteristics for their T cell polarizing ability. This thesis tries to address that question by studying the metabolism of dendritic cells after in vitro stimulation with antigens or immunomodulatory compounds that are known to prime either T helper 1 cells, T helper 2 cells, T helper 17 cells or regulatory T cells. In addition, we interrogate the role of liver kinase B1 (LKB1) and mechanistic target of rapamycin complex 1 (mTORC1) in DC biology.LUMC / Geneeskund

Health effects and burden of disease due to exposure to chemicals at the workplace - an exploratory study

The RIVM investigated the probable contribution of exposure to chemicals at the workplace as the cause of some ten diseases. This exploratory study was requested by of the Ministry of Social Affairs and Employment, and presents for the first time an integrated estimation of the burden of disease due to occupational exposure to chemicals.For nine investigated diseases the study resulted in a burden of disease of approximately 47,000 DALYs, including about 1,900 deaths, due to exposure to chemicals at the workplace. DALY stands for 'Disability Adjusted Life Years', in which premature death and years with disease are weighted counted up. The largest contributions are formed by mesothelioma, lung cancer, asthma, and chronic obstructive pulmonary disease. The margin of uncertainty in the results is very large, mainly caused by the scarce and incomplete data, and amounts about a factor of 5.It was not possible to estimate the burden of disease due to reproductive disorders following occupational exposure to chemicals. However, results of recent research in this area indicate concern.Het RIVM heeft onderzocht wat het aandeel zou kunnen zijn van blootstelling aan chemische stoffen op de werkplek op het ontstaan van een tiental ziekten. Dit verkennende onderzoek is uitgevoerd in opdracht van het Ministerie van Sociale Zaken en Werkgelegenheid en geeft voor het eerst een integrale schatting van de ziektelast door blootstelling aan stoffen in de arbeidssituatie.De uitkomst van het onderzoek is dat voor negen onderzochte ziekten de blootstelling aan stoffen in de arbeidssituatie een geschatte ziektelast oplevert van ongeveer 47.000 DALY's per jaar, inclusief naar schatting circa 1.900 sterfgevallen. DALY staat voor 'Disability Adjusted Life Years', waarin vroegtijdige sterfte en jaren doorgebracht met ziekte op gewogen wijze bij elkaar worden opgeteld. De grootste bijdragen worden gevormd door borstvlieskanker, longkanker, astma en chronische luchtwegobstructie.De marge van onzekerheid in de genoemde uitkomsten is erg groot, wat vooral veroorzaakt wordt door de onvolledige gegevens, en bedraagt ongeveer een factor 5.Voor reproductiestoornissen was het niet mogelijk om een schatting te maken van de ziektelast tengevolge van werkgerelateerde blootstelling aan stoffen. De resultaten van recent onderzoek naar de relatie tussen blootstelling aan stoffen en reproductiestoornissen geven echter aanleiding tot zorg