Learning About Integrated Development Using Longitudinal Mixed Methods Programme Evaluation

Globally, millions of children are living without parental care. Families experience multiple challenges that lead to family–child separation, with financial hardship a common theme. The integration of interventions to strengthen families socially, emotionally, and economically is therefore a priority, but requires knowing which combination(s) of interventions might work for which households. This article reflects on an ongoing evaluation of two projects in Uganda that implemented integrated family and economic strengthening interventions with families at risk of a child being separated and those where a separated child was reunited. We discuss how the practical realities of integrated programming influence research design options and our attempts to mitigate the potential limitations of a non‑experimental design with the use of a mixed methods approach.Department for International Development (DFID

Recommendations for ethical approaches to genotype-driven research recruitment

Recruiting research participants based on genetic information generated about them in a prior study is a potentially powerful way to study the functional significance of human genetic variation. However, it also presents significant ethical challenges that, to date, have received only minimal consideration. We convened a multi-disciplinary workshop to discuss key issues relevant to the conduct and oversight of genotype-driven recruitment and to translate those considerations into practical policy recommendations. Workshop participants were invited from around the U.S., and included genomic researchers and study coordinators, research participants, clinicians, bioethics scholars, experts in human research protections, and government representatives. Discussion was directed by experienced facilitators and informed by empirical data collected in a national survey of IRB chairs and in-depth interviews with research participants in studies where genotype-driven recontact occurred. A high degree of consensus was attained on the resulting 7 recommendations, which cover informed consent disclosures and choices, the process for how and by whom participants are recontacted, the disclosure of individual genetic research results, and the importance of tailoring approaches based on specific contextual factors. These recommendations are intended to represent a balanced approach—protecting research participants, yet avoiding overly restrictive policies that hinder advancement on important scientific questions

Research Participants' Perspectives on Genotype-Driven Research Recruitment

Genotype-Driven Recruitment is a potentially powerful approach for studying human genetic variation but presents ethical challenges. We conducted in-depth interviews with research participants in six studies where such recruitment occurred. Nearly all responded favorably to the acceptability of recontact for research recruitment, and genotype-driven recruitment was viewed as a positive sign of scientific advancement. Reactions to questions about the disclosure of individual genetic research results varied. Common themes included explaining the purpose of recontact, informing decisions about further participation, reciprocity, “information is valuable,” and the possibility of benefit, as well as concerns about undue distress and misunderstanding. Our findings suggest contact about additional research may be least concerning if it involves a known element (e.g., trusted researchers). Also, for genotype-driven recruitment, it may be appropriate to set a lower bar for disclosure of individual results than the clinical utility threshold recommended more generally

Advancing HIV research with pregnant women: navigating challenges and opportunities

Concerns about including pregnant women in research have led to a dearth of evidence to guide safe and effective treatment and prevention of HIV in pregnancy. To better understand why these evidence gaps persist and inform guidance for responsible inclusion of pregnant women in the HIV research agenda, we aimed to learn what HIV experts perceive as barriers and constraints to conducting this research

Social conduct, learning and innovation: an abductive study of the dark side of agile software development

Agile methodologies have been adopted by an increasing number of organizations to improve their responsiveness. However, few studies have empirically analysed the effect of Agile on long-term organizational goals such as learning and innovation. Using an abductive approach, this study examines the relationships between self-regulated teams’ social conduct and their resulting learning and innovation. Results indicate that the perceived time pressure to get the job done greatly impedes team engagement in learning and innovation activities. Time pressure is affected by the various control strategies deriving from the implementation of Agile, which constitute its dark side: concertive, belief, diagnostic and boundary controls