Evidence attribution in the UniProt Knowledgebase

UniProtKB provides the scientific community with a comprehensive collection of protein sequence records containing extensive curated information including functional and sequence annotation. This information is derived from a variety of sources such as scientific literature and sequence analysis programs as well as data imported from automatic annotation systems and external databases. To allow users to ascertain the origin of each data item in a UniProtKB record, an evidence attribution system is being introduced which links each piece of information to its original source. This system allows users to trace the origin of all information, to differentiate easily between experimental and computational data, and to assess data reliability. The current system and plans for its future development and enhancement will be presented

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Poem by Eric Magrane

Effect of Exercise and Caloric Restriction on DMBA-Induced Mammary Tumorigenesis and Plasma Lipids in Rats fed High Fat Diets

A report submitted by David Magrane to the Research and Creative Production Committee in 1990 on effect of exercise and caloric restriction on DMBA-induced mammary tumorigenesis and plasma lipids in rats fed high fat diets

Characterization of Steroid Hormone Binding by the Synthetic Steroid, Danazol, to Cytoplasmic Receptors of Target Cells

A report by David Magrane submitted to the Faculty Research Committee in 1982 on the intracellular mechanisms underlying steroid regulation of target cells

Mechanism of Action of Adrenocorticotropin on the Isolated Adrenal Cell

A report submitted to the Faculty Research Committee by David Magrane in 1976 on the mechanism of action of Adrenocorticotropin on the isolated adrenal cell

Characterization of Steroid Hormone Binding and Induction in Estrogen Dependent Mammary Carcinomas

A report submitted by David Magrane to the Faculty Research Committee in 1983 on steroid hormone receptors and estrogen dependent mammary carcinomas

Sustainable Tourism Planning in Copenhagen; How Copenhagen uses a sustainable tourism model to create a liveable city

This research focuses on Copenhagen’s tourism planning. Over the past decades, the number of tourists in this city have grown exponentially. This trend expects to continue, with many experts believing tourism numbers to double by 2030. Therefore, the importance of a sustainable tourism model is of utmost importance. There is a necessity to re-imagine tourism and this study investigates how the city of Copenhagen changes the narrative from attracting mass tourism, to one that focuses on liveability of the city for both residents and tourists alike. Increased tourism is a two-fold issue, on one side it brings economic benefits into the city, while on the other side, it negatively impacts the city and its users. Using secondary data, this research analyses Wonderful Copenhagen’s strategies to prevent Overtourism. This paper contributes by providing a study with which to better understand the origins of Overtourism, its implications, and predicted future perspectives in respect to the issue. It brings to light progressive and experimental tourism models that seek to create sustainable tourism. This research found tourism planning in Copenhagen, a city not yet facing excessive tourism, has boldly taken steps towards re-imagining how tourism is marketed and dealt with. Significant effort in tackling or reversing the negative impacts of tourism has resulted in Copenhagen becoming a world leader in sustainable tourism practises and a role model for other cities to follow

UniProt Knowledgebase: a hub of integrated data

Data integration plays an increasingly important role in bringing together the large amounts of diverse information spread across disparate resources and presenting a comprehensive overview of these data to the scientific community. The UniProt Knowledgebase (UniProtKB) acts as a central hub of protein knowledge by providing a unified view of protein sequence and functional information. Manual and automatic annotation procedures are used to add data directly to the database while extensive cross-referencing to more than 120 external databases provides access to additional relevant information in more specialised data collections. UniProtKB also integrates data such as protein sequences, protein-protein interactions, Gene Ontology terms and official gene nomenclature from a range of resources. All information in UniProtKB is attributed to its original source, allowing users to trace the provenance of all data. In addition, UniProtKB data is made freely available in a range of formats to facilitate integration with other databases and the UniProt Consortium is committed to using and promoting common data exchange formats and technologies. This approach ensures that information is captured in the most appropriate resource for subsequent integration with other databases and also ensures maximum curation efficiency by preventing duplication of efforts across multiple resources. How UniProt achieves this data capture and integration will be presented. The UniProt resource is available at "www.uniprot.org":http://www.uniprot.org