ISAR: Ein Autorensystem für Interaktive Tische

Developing augmented reality systems involves several challenges, that prevent end users and experts from non-technical domains, such as education, to experiment with this technology. In this research we introduce ISAR, an authoring system for augmented reality tabletops targeting users from non-technical domains. ISAR allows non-technical users to create their own interactive tabletop applications and experiment with the use of this technology in domains such as educations, industrial training, and medical rehabilitation.Die Entwicklung von Augmented-Reality-Systemen ist mit mehreren Herausforderungen verbunden, die Endbenutzer und Experten aus nicht-technischen Bereichen, wie z.B. dem Bildungswesen, daran hindern, mit dieser Technologie zu experimentieren. In dieser Forschung stellen wir ISAR vor, ein Autorensystem für Augmented-Reality-Tabletops, das sich an Benutzer aus nicht-technischen Bereichen richtet. ISAR ermöglicht es nicht-technischen Anwendern, ihre eigenen interaktiven Tabletop-Anwendungen zu erstellen und mit dem Einsatz dieser Technologie in Bereichen wie Bildung, industrieller Ausbildung und medizinischer Rehabilitation zu experimentieren

Tractography Delineates Microstructural Changes in the Trigeminal Nerve after Focal Radiosurgery for Trigeminal Neuralgia

PURPOSE: Focal radiosurgery is a common treatment modality for trigeminal neuralgia (TN), a neuropathic facial pain condition. Assessment of treatment effectiveness is primarily clinical, given the paucity of investigational tools to assess trigeminal nerve changes. Since diffusion tensor imaging (DTI) provides information on white matter microstructure, we explored the feasibility of trigeminal nerve tractography and assessment of DTI parameters to study microstructural changes after treatment. We hypothesized that trigeminal tractography provides more information than 2D-MR imaging, allowing detection of unique, focal changes in the target area after radiosurgery. Changes in specific diffusivities may provide insight into the mechanism of action of radiosurgery on the trigeminal nerve. METHODS AND MATERIALS: Five TN patients (4 females, 1 male, average age 67 years) treated with Gamma Knife radiosurgery, 80 Gy/100% isodose line underwent 3Tesla MR trigeminal nerve tractography before and sequentially up to fourteen months after treatment. Fractional anisotropy (FA), radial (RD) and axial (AD) diffusivities were calculated for the radiosurgical target area defined as the region-of-interest. Areas outside target and the contralateral nerve served as controls. RESULTS: Trigeminal tractography accurately detected the radiosurgical target. Radiosurgery resulted in 47% drop in FA values at the target with no significant change in FA outside the target, demonstrating highly focal changes after treatment. RD but not AD changed markedly, suggesting that radiosurgery primarily affects myelin. Tractography was more sensitive than conventional gadolinium-enhanced post-treatment MR, since FA changes were detected regardless of trigeminal nerve enhancement. In subjects with long term follow-up, recovery of FA/RD correlated with pain recurrence. CONCLUSIONS: DTI parameters accurately detect the effects of focal radiosurgery on the trigeminal nerve, serving as an in vivo imaging tool to study TN. This study is a proof of principle for further assessment of DTI parameters to understand the pathophysiology of TN and treatment effects

Sensorimotor and Pain Modulation Brain Abnormalities in Trigeminal Neuralgia: A Paroxysmal, Sensory-Triggered Neuropathic Pain

Idiopathic trigeminal neuralgia (TN) is characterized by paroxysms of severe facial pain but without the major sensory loss that commonly accompanies neuropathic pain. Since neurovascular compression of the trigeminal nerve root entry zone does not fully explain the pathogenesis of TN, we determined whether there were brain gray matter abnormalities in a cohort of idiopathic TN patients. We used structural MRI to test the hypothesis that TN is associated with altered gray matter (GM) in brain areas involved in the sensory and affective aspects of pain, pain modulation, and motor function. We further determined the contribution of long-term TN on GM plasticity

Zur Einführung: Die Chamisso-Literatur

Mit der Frage nach sprachlicher und kultureller Zugehörigkeit befassen sich Menschen seit jeher. Viele Antworten auf diese Frage sind ethnonational motiviert und somit homogenisierend einfach. In einer Welt, die immer stärker von Globalisierung und Migration geprägt wird, werden immer mehr Stimmen laut, die sich auf der Suche nach Antworten nicht mit einem „Entweder-Oder“ begnügen, sondern die lebensweltlichen Prozesse der Verflechtung und Durchmischung in den Mittelpunkt ihrer Selbst- und Fremdwahrnehmung stellen.Literarisch verarbeitet führt dies zu Darstellungsmustern, die homogenisierende und somit vereinfachende, veraltete bzw. konstruierte ethnonational motivierte Grenzziehungen in Frage stellen. Ihr hybrider Charakter schafft sprachlich und inhaltlich Neues, das nicht nur durch sein Innovationspotential besticht, sondern auch aufgrund seiner Mehrfachzugehörigkeit alte Macht- und Wissensstrukturen dekonstruiert.Die vorliegende ZIF-Ausgabe widmet sich solchen literarischen Schaffensprozessen, die im Folgenden unter „interkultureller Literatur“ zusammengefasst werden. Am Beispiel der so genannten „Chamisso-Autorinnen und -Autoren“ setzen sich die Beiträgerinnen und Beiträger mit interkultureller Literatur im Kontext der Literaturwissenschaft sowie Literaturdidaktik auseinander und diskutieren ihren gesellschaftlichen Stellenwert

“If you are holding this letter”

“If you are holding this letter” a historical fiction novella that educates readers about the historical significance of World War II: what it was like to be an American soldier fighting in Europe and how the war effected the personal lives those on the home front. Through first-person narration, this thesis exposes readers to the horrors of the reality of war and soldiers’ miseries; the shifting gender norms in the United States; the passionate patriotism both at home and abroad; and the love between two seemingly insignificant young people as they navigate the tumultuous times of WWII through their devoted letters. This thesis consists of fictional prayers and letters between an American soldier fighting the war abroad and his girlfriend living in Chicago, Illinois. The soldier, Thomas Hartley, is first stationed in France and later, Poland. His girlfriend, Donna Mayes, gains her first employment opportunity working in a war production factory. Through letters and prayers from Thomas and Donna, the devastation of WWII is apparent in the lives of both soldiers and civilians at home, but, as the story illustrates, the war also brought great joy and fulfillment in some cases

Comparison of Diffusion-Weighted MRI Reconstruction Methods for Visualization of Cranial Nerves in Posterior Fossa Surgery

Diffusion-weighted imaging (DWI)-based tractography has gained increasing popularity as a method for detailed visualization of white matter (WM) tracts. Different imaging techniques, and more novel, advanced imaging methods provide significant WM structural detail. While there has been greater focus on improving tract visualization for larger WM pathways, the relative value of each method for cranial nerve reconstruction and how this methodology can assist surgical decision-making is still understudied. Images from 10 patients with posterior fossa tumors (4 male, mean age: 63.5), affecting either the trigeminal nerve (CN V) or the facial/vestibular complex (CN VII/VIII), were employed. Three distinct reconstruction methods [two tensor-based methods: single diffusion tensor tractography (SDT) (3D Slicer), eXtended streamline tractography (XST), and one fiber orientation distribution (FOD)-based method: streamline tractography using constrained spherical deconvolution (CSD)-derived estimates (MRtrix3)], were compared to determine which of these was best suited for use in a neurosurgical setting in terms of processing speed, anatomical accuracy, and accurate depiction of the relationship between the tumor and affected CN. Computation of the tensor map was faster when compared to the implementation of CSD to provide estimates of FOD. Both XST and CSD-based reconstruction methods tended to give more detailed representations of the projections of CN V and CN VII/VIII compared to SDT. These reconstruction methods were able to more accurately delineate the course of CN V and CN VII/VIII, differentiate CN V from the cerebellar peduncle, and delineate compression of CN VII/VIII in situations where SDT could not. However, CSD-based reconstruction methods tended to generate more invalid streamlines. XST offers the best combination of anatomical accuracy and speed of reconstruction of cranial nerves within this patient population. Given the possible anatomical limitations of single tensor models, supplementation with more advanced tensor-based reconstruction methods might be beneficial

Preliminary evidence for human globus pallidus pars interna neurons signaling reward and sensory stimuli.

The globus pallidus pars interna (GPi) is a component of the basal ganglia, a network of subcortical nuclei that process motor, associative, and limbic information. While non-human primate studies have suggested a role for the GPi in non-motor functions, there have been no single-unit studies of non-motor electrophysiological behavior of human GPi neurons. We therefore sought to extend these findings by collecting single-unit recordings from awake patients during functional stereotactic neurosurgery targeting the GPi for deep brain stimulation. To assess cellular responses to non-motor information, patients performed a reward task where virtual money could be won, lost, or neither, depending on their performance while cellular activity was monitored. Changes in the firing rates of isolated GPi neurons after the presentation of reward-related stimuli were compared between different reward contingencies (win, loss, null). We observed neurons that modulated their firing rate significantly to the presentation of reward-related stimuli. We furthermore found neurons that responded to visual-stimuli more broadly. This is the first single-unit evidence of human GPi neurons carrying non-motor information. These results are broadly consistent with previous findings in the animal literature and suggest non-motor information may be represented in the single-unit activity of human GPi neurons.NAH is supported by a Unilever/Lipton Graduate Fellowship in Neuroscience and a University of Toronto Fellowship. WDH is supported by a CIHR operating grant (98006). VV is a Wellcome Trust (WT) intermediate Clinical Fellow (WT093705MA).This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.neuroscience.2016.04.02