Innovation at the Keck Observatory

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Humanities, Program in Writing and Humanistic Studies, 2005.Includes bibliographical references (leaves 27-30).A study of historical, current, and future developments at the Keck Observatory revealed a thriving philosophy of innovation. Intended to defy obsoletion and keep the observatory competitive over long time scales, this philosophy continues to resonate with Keck Observatory scientists. The Keck Observatory consists of two 1 0-meter telescopes situated near the apex of Mauna Kea on the big island of Hawaii. Three main innovations keep the observatory competitive. The observatory contains the first modem active optics-controlled segmented primary mirror, principally designed by Dr. Jerry Nelson. Though it currently reigns as the world's largest aperture at 10 meters, monolithic mirror supporters still question its viability. The observatory also links both primary mirrors together as a single 20-meter telescope using interferometry. Finally, the observatory employs both a natural and laser guide star adaptive optics system. Forward-thinking Keck scientists, however, are researching multi-conjugate adaptive optics systems. As a result of its innovations, Keck has retained its position as a major player in the realm of observational astronomy for over a decade.by Monica Godha Bobra.S.M

Land and Infrastructure Development in Peri-Urban Areas: Case Study of Gomti Nagar, Lucknow, India

The objectives of the paper is to determine the status of land and infrastructure in the peri-urban areas of Lucknow Municipal Corporation (LMC). Lucknow, being the capital of most populated state of the country, has lots of migration in search of jobs and better education. The growth of Lucknow peri-urban areas has propelled by the economic growth and demographic pressure. The growth of peri-urban areas has of the city has to sustain over a period of time. However, the predominance of growth form over the period of time has significant harmful impacts. It has thwarted mass transit development, separated rich and poor, caused unnecessary travel, consumed fragile land, and generated excessive public expenditures. The paper has tried to pursue three key objectives of the development of land and infrastructure in peri-urban areas of the Lucknow city. The first was to elaborate the main conceptual and theoretical debates concerned with peri-urban areas. Second, the paper considered planned development of land and infrastructure as an option for sustainable development of peri-urban areas. Third, how planned development of land and infrastructure would help other Indian cities in providing better services to their citizens

Biological and Social Economic Determinants of Adherence and Cure of Tuberculosis Treatment: Path Analysis Evidence from Yogyakarta

Background: Tuberculosis (TB) was an infectious disease which was still a health problem world­wide, including in Indonesia, which only had a population of around 261 million. The purpose of this study was to analyze biological and social economic determinants of adherence and cure of TB treatment.Subjects and Method: This was an analytic observational study with a case control design. The study was conducted in Bantul, Yogyakarta, from April to May 2019. A sample of 225 TB patients was selected by random sampling. The dependent variable was adherence and cure of TB treat­ment. The independent variables were age, gender, education, family income, nutritional status, healthy behavior, complication, family support, drug taking supervisor, drug taking adherence, environment, and smoking. The data were collected by questionnaire and analyzed by path analysis.Results: Adherence and cure of TB treat­ment was directly increased with good nutritional status (b= 076; 95% CI= 0.03 to 1.49; p= 0.042), drug taking adherence (b= 3.67; 95% CI= 1.47 to 5.92; p= 0.001), drug taking supervisor (b= 3.64; 95% CI= 1.26 to 6.02; p= 0.003), strong family support (b= 2.03; 95% CI= -3.85 to -0.21; p= 0.029), and healthy physical environment (b= 4.05; 95% CI= - 0.09 to 8.20; p= 0.056). Adherence and cure of TB treat­ment was directly decreased with age ≥65 years old (b= -0.54; 95% CI= - 1.85 to 0.75; p= 0.411), female gender (b= -0.05; 95% CI= - 0.86 to 0.76; p= 0.900), unhealthy behavior (b= -3.20; 95% CI= - 5.02 to -1.36; p= 0.001), smoking (b= -1.50; 95% CI= - 2.56 to -0.43; p= 0.006), complication (b= -1.41; 95% CI= - 2.60 to -0.23; p= 0.019). It was indirectly affected by nutritional status, education, family income, and healthy environment.Conclusion: Adherence and cure of TB treat­ment is directly increased with good nutritional status, drug taking adherence, drug taking supervisor, strong family support, and healthy physical environment. Adherence and cure of TB treat­ment is directly decreased with age ≥65 years old, female gender, unhealthy behavior, smoking, complication. It is indirectly affected by nutritional status, education, family income, and healthy environment.Keywords: tuberculosis treat­ment, drug taking adherence, path analysisCorrespondence: Tri Godha Fitriani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +6287738200610.Journal of Epidemiology and Public Health (2019), 4(4): 270-282 https://doi.org/10.26911/jepublichealth.2019.04.04.0

Role of maternal serum ferritin as a predictive marker in intrauterine growth restriction

Background: Intrauterine growth restriction (IUGR) is most common and distressing complication for both obstetrician and neonatologist. Measurement of maternal serum ferritin has also been used as a predictive marker of increase risk of IUGR. In pregnancy, ferritin level decreases with advancing gestation. Its lowest level is seen around 30-32 weeks of gestational age after which its concentration reaches plateau level.Methods: Total 326 antenatal women enrolled in the study. Maternal serum samples of all women were taken at 25th week and again at 30-32 weeks in trace free mineral evacuated tubes for assessment of serum ferritin by chemiluminescence. Mean of both values was calculated.Results: Mean ferritin value of women with average for gestational age neonates was 15.49 ng/ml and women with growth restricted neonates was 19.71 ng/ml. The women with mean serum ferritin above 20 ng/ml, were 6.26 times more likely to have asymmetrically growth restricted baby and 4.47 times more likely to have a symmetrically growth restricted baby when compared to women with serum ferritin value less then <20 ng/ml.Conclusions: In our study negative correlation was found between the value of serum ferritin and neonatal birth weight. In future large randomized control trial is needed to found association between maternal serum ferritin and IUGR.

A study of Relationship Marketing in business-to-business markets focusing on the Indian Jewellery sector

Relationship marketing today is one the most talked about contemporary marketing strategies and a new paradigm in marketing over a last few decades. However, the operational aspects of this paradigm are still vague and need more investigation. The purpose of this research is to understand the effect of relationship marketing in business-to-business sector emphasizing on Indian gems and jewellery Industry and how different factors add to the creation and development of relationships. The literature review discusses the emergence of relationship marketing, reasons for the shift from transactional to relationship marketing, types of relationship marketing, and factors leading to the development of relationships. For the purpose of this research qualitative research methodology has been chosen. The researcher has used 9 in-depth interviews to collect data in order to understand and satisfy the aims and objectives of this research. The results from the interviews have been analyzed and discussed by dividing them into various themes based on the literature review. Lastly, the concluding thoughts of this study discuss the limitations and recommendations

Adhesion of acidic lipid vesicles by 21.5 kDa (recombinant) and 18.5 kDa isoforms of myelin basic protein

AbstractMyelin basic protein (MBP) is thought to be responsible for adhesion of the intracellular surfaces of compact myelin to give the major dense line. The 17 and 21.5 kDa isoforms containing exon II have been reported by others to localize to the cytoplasm and nucleus of murine oligodendrocytes and HeLa cells while the 14 and 18.5 kDa isoforms lacking exon II are confined to the plasma membrane. However, we show that the exon II− 18.5 kDa form and a recombinant exon II+ 21.5 kDa isoform both caused similar aggregation of acidic lipid vesicles, indicating that they should have similar abilities to bind to the intracellular lipid surface of the plasma membrane and to cause adhesion of those surfaces to each other. The circular dichroism spectra of the two isoforms indicated that both had a similar secondary structure. Thus, both isoforms should be able to bind to and cause adhesion of the cytosolic surfaces of compact myelin. The fact that they do not could be due to differences in post-translational modification in vivo, trafficking through the cell and/or subcellular location of synthesis, but it is not due to differences in their lipid binding

Juvenile Nasopharyngeal Angiofibroma - A Case Report

15 year old male who presented with a 6 month history of nasal obstruction and recurrent nasal bleeding. He had had about ten episodes of epistaxis in the 3 months. Examination revealed that vital signs were essentially within normal limits.The nasal cavity revealed fresh blood in the right nasal cavity but the bleeding site could not be visualized. An impression of epistaxis secondary rhinosinusitis was made

Design and Testing of a Multi-Sensor Pedestrian Location and Navigation Platform

Navigation and location technologies are continually advancing, allowing ever higher accuracies and operation under ever more challenging conditions. The development of such technologies requires the rapid evaluation of a large number of sensors and related utilization strategies. The integration of Global Navigation Satellite Systems (GNSSs) such as the Global Positioning System (GPS) with accelerometers, gyros, barometers, magnetometers and other sensors is allowing for novel applications, but is hindered by the difficulties to test and compare integrated solutions using multiple sensor sets. In order to achieve compatibility and flexibility in terms of multiple sensors, an advanced adaptable platform is required. This paper describes the design and testing of the NavCube, a multi-sensor navigation, location and timing platform. The system provides a research tool for pedestrian navigation, location and body motion analysis in an unobtrusive form factor that enables in situ data collections with minimal gait and posture impact. Testing and examples of applications of the NavCube are provided