An international, multicentre evaluation and description of Burkholderia pseudomallei infection in cystic fibrosis

BACKGROUND: Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies. METHODS: We performed a literature search to identify all published cases of B. pseudomallei infection in CF. In addition we hand-searched respiratory journals, and contacted experts in infectious diseases and CF around the world. Supervising clinicians for identified cases were contacted and contemporaneous clinical data was requested. RESULTS: 25 culture-confirmed cases were identified. The median age at acquisition was 21 years, mean FEV(1) % predicted was 60 %, and mean BMI was 19.5 kg/m(2). The location of acquisition was northern Australia or south-east Asia for most. 19 patients (76 %) developed chronic infection, which was usually associated with clinical decline. Successful eradication strategies included a minimum of two weeks of intravenous ceftazidime, followed by a consolidation phase with trimethoprim/sulfamethoxazole, and this resulted in a higher chance of success when instituted early. Three cases of lung transplantation have been recorded in the setting of chronic B. pseudomallei infection. CONCLUSION: Chronic carriage of B. pseudomallei in patients with CF appears common after infection, in contrast to the non-CF population. This is often associated with an accelerated clinical decline. Lung transplantation has been performed in select cases of chronic B. pseudomallei infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0109-9) contains supplementary material, which is available to authorized users

Acute spontaneously resolving pulmonary vasculitis: a case report

This is the first description that we are aware of describing the spontaneous resolution of an acute pulmonary vasculitis, possibly secondary to microscopic polyangiitis. Haemoptysis is a common symptom for patients presenting to primary and tertiary referral centres, and pulmonary vasculitis is one of a variety of aetiologies that should always be considered. The pulmonary vasculitides are difficult diagnostic and management problems. They are encumbered by a relative paucity of level 1 evidence addressing their diagnosis, classification, and treatment. This is therefore an important paper to publish because it adds to the global breadth of experience with this important clinical condition.James B. Geake, and Graeme Maguir

Theory of Dispersed Fixed-Delay Interferometry for Radial Velocity Exoplanet Searches

The dispersed fixed-delay interferometer (DFDI) represents a new instrument concept for high-precision radial velocity (RV) surveys for extrasolar planets. A combination of Michelson interferometer and medium-resolution spectrograph, it has the potential for performing multi-object surveys, where most previous RV techniques have been limited to observing only one target at a time. Because of the large sample of extrasolar planets needed to better understand planetary formation, evolution, and prevalence, this new technique represents a logical next step in instrumentation for RV extrasolar planet searches, and has been proven with the single-object Exoplanet Tracker (ET) at Kitt Peak National Observatory, and the multi-object W. M. Keck/MARVELS Exoplanet Tracker at Apache Point Observatory. The development of the ET instruments has necessitated fleshing out a detailed understanding of the physical principles of the DFDI technique. Here we summarize the fundamental theoretical material needed to understand the technique and provide an overview of the physics underlying the instrument's working. We also derive some useful analytical formulae that can be used to estimate the level of various sources of error generic to the technique, such as photon shot noise when using a fiducial reference spectrum, contamination by secondary spectra (e.g., crowded sources, spectroscopic binaries, or moonlight contamination), residual interferometer comb, and reference cross-talk error. Following this, we show that the use of a traditional gas absorption fiducial reference with a DFDI can incur significant systematic errors that must be taken into account at the precision levels required to detect extrasolar planets.Comment: 58 pages, 11 figures, 1 table, 3 appendices. Accepted for publication in ApJS. Minor typographical corrections; update to acknowledgment

Biological action of 1.1-dimethylhydrazine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31963/1/0000005.pd

Effective CCTV and the challenge of constructing legitimate suspicion using remote visual images

This paper compares the effectiveness of public CCTV systems according to meta-reviews, with what might be expected based upon theoretical predictions. The apparent gulf between practice and prediction is explored in the light of the challenges faced by CCTV operators in terms of effective target selection. In addition, counter-intuitive reactions by members of the public to situational symbols of crime deterrence may also undermine the efficacy of CCTV. Evidence is introduced and reviewed that suggests CCTV operators may employ implicit profiles to select targets. Essentially, young, scruffy males who appear to be loitering are disproportionately targeted compared with their base rate use of surveyed areas. However, the extent to which such a profile is diagnostic of criminal intent or behaviour is unclear. Such profiles may represent little more than ‘pattern matching’ within an impoverished visual medium. Finally, suggestions for future research and effective CCTV operator practice are offered in order to improve target selection.Peer reviewe

Vitamin B6, and the toxicity of 1,1-dimethylhydrazine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33416/1/0000817.pd

Lunar dust characterization by polarimetric signature. I. Negative polarization branch of sphere aggregates of various porosities

Context. In support of NASA's exploration program and the return to the Moon, the polarimetric signature of dispersed individual Lunar regolith dust grains is studied to enable the characterization of the dust exopsheric environment by remote, in-situ, and standoff sensing. Aims. We explore the value of the negative polarization branch (NPB) as a signature for characterizing individual grains to determine if it can be used in the same way as for surfaces of planets and atmosphereless bodies. Results. Calculations show that polarization phase curves for spherical grains exhibit a sharp transition over a narrow range of size parameter between two distinct regimes, one typical of Rayleigh scattering and another dominated by a large NPB. The linear polarimetric signature observed for aggregates is a composite of a) the polarization induced by individual grains composing the aggregate and b) the polarization due to the aggregate as a whole dust grain. The weight of each component varies depending on the porosity of the aggregate. An NPB similar to the one observed for atmosphereless astronomical bodies is present for different ranges of the size parameter depending on the value of the porosity. It appears as a remnant of the negative branch exhibited by the single spherical grains. The sharper, narrow negative branch that is measured for some granular surfaces in the laboratory or seen in astronomical observations is not observed here.Comment: 7 pages, 8 figures, accepted for publication in Astronomy & Astrophysic