Quality assessment of studies comparing percutaneous ablative treatments in hepatocellular carcinoma.

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Glucose intolerance and hepatocellular carcinoma: recent findings for old diseases

In the last years, an increasing number of evidences on the influence of metabolic syndrome on the occurrence of hepatocellular carcinoma (HCC) have been developed. Type 2 mellitus diabetes (T2MD) has been found to increase the occurrence of primary liver tumors and to define a more aggressive carcinogenetic process. Furthermore, several preclinical and observational studies and a recent meta-analysis have shown that anti-diabetic drugs can modify the risk of HCC development in patients with T2DM. However, despite these evidences, underlying molecular mechanisms linking both pathological conditions have to be completely cleared yet. The study published by Gao et al. has found a possible molecular link between the two conditions, describing the predisposition to T2DM and HCC given by the haploinsufficiency of nuclear receptor coactivator 5 (NCOA5) in murine models. The authors have generated Ncoa5+/– (haploinsufficient) male mice and shown that 94% of male mutant mice developed HCC within 18 months of age, this in contrast with Ncoa5+/+ and Ncoa5+/– female mice. These results suggest that NCOA5 haploinsufficiency is linked to HCC development in male mice. Moreover, mutant male mice showed significantly elevated levels of fasting blood glucose and markedly decreased glucose tolerance and insulin sensitivity compared to Ncoa5+/+ littermates. This well-constructed work sheds light on the molecular link between T2DM and HCC and opens the way to further biological and clinical studies in the field of liver tumor prevention and treatment

Repeated transarterial chemoembolization: An overfitting effort?

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Designing Of Curricula Of Environmental Engineering And Constructions Engineering For Sustainability

The experience carried out at the University of Florence, Department of Civil and Environmental Engineering, in designing two new undergraduate curricula in “Environmental Engineering” and “Civil and Building Engineering for sustainability”, is reported. The bachelor in Environmental Engineering aims to train engineers capable of working in the field of protection of environment, territory and natural resources. The bachelor in Civil and Building Engineering for sustainability aims to train engineers capable of working in the field of structures, infrastructures, and constructions in general, as well as management and safety of construction processes. The development of the two curricula was based preliminarily on a national and international survey of degree programs of the same type and with shared learning outcomes. Subsequently, labour market needs were identified starting from discussions with all stakeholders, students and professors included. Teaching methods and methods for assessing students\u27 preparation have also been revised and the teaching plan of both curricula is characterized in the third year by the presence of multidisciplinary laboratories, focused on the most characterizing themes of each programme and the different disciplines with integrative and specific in-depth characteristics. Finally, a thorough design of the two courses contents has been initiated, based on the definition of the general educational objectives and the specific disciplines