The Relationship Between Caregiver Intimate Partner Violence, Posttraumatic Stress, Child Cognitive Self-development, And Treatment Attrition Among Child Sexual Abuse Victims.

Child sexual abuse (CSA) is a worldwide problem, with two-thirds of all cases going unreported. A wealth of research over the last 30 years demonstrates the negative emotional, cognitive, physical, spiritual, academic, and social effects of CSA. As a result, researchers and mental health professionals frequently attempt to measure the efficacy of treatment modalities in order to assess which treatments lead to better outcomes. However, in order to effectively study treatment outcomes, researchers must be able to track the status of child functioning and symptomology before, during, and after treatment. Because high levels of treatment attrition exist among CSA victims, researchers are unable to effectively study outcomes due to large losses in research participants, loss of statistical power, and threats to external validity (Kazdin, 1990). Moreover, due to the high prevalence of concurrent family violence, caregivers with intimate partner violence are more than twice as likely to have children who are also direct victims of abuse (Kazdin, 1996). Caregivers ultimately make the decisions regarding whether or not a child stays in treatment, and therefore, it is important to examine the influence of both parent factors (e.g., intimate partner violence) and child factors (e.g., traumatization and/or disturbances in cognitive selfdevelopment) on treatment attrition. This two-pronged approach of examining both child and family characteristics simultaneously with attrition patterns offers a more complete picture for the ways concurrent family violence influences treatment than looking at child and caregiver factors separately. The purpose of this study was to investigate the relationships between caregiver intimate partner violence, child posttraumatic stress (Trauma Symptom Checklist for Children [TSCC]; Briere, 1996), child cognitive self-development (Trauma and Attachment Belief Scale [TABS]; iv Pearlman, 2003), and treatment attrition. The statistical analyses in this study included (a) Logistic Regression, (b) Poisson Regression, and (c) Chi-square Test for Independence. Elevated TSCC subscale scores in posttraumatic stress predicted both an increased number of sessions attended and increased number of sessions missed. Elevated TABS subscale scores in self-trust predicted an increased number of sessions attended and decreased number of sessions missed. Elevated TABS subscale scores of other-intimacy and self-control predicted an increased number of sessions missed. Moreover, the presence of past or current caregiver intimate partner violence predicted a decrease in number of sessions attended. While no relationship existed between child posttraumatic stress or cognitive self-development and whether a child graduated or prematurely terminated from treatment, children with parents who confirmed past or current intimate partner violence were 2.5 times more likely to prematurely terminate from treatment

Sensitivity Analysis of the MGMT-STP27 Model and Impact of Genetic and Epigenetic Context to Predict the MGMT Methylation Status in Gliomas and Other Tumors.

The methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is an important predictive biomarker for benefit from alkylating agent therapy in glioblastoma. Our model MGMT-STP27 allows prediction of the methylation status of the MGMT promoter using data from the Illumina's Human Methylation BeadChips (HM-27K and HM-450K) that is publically available for many cancer data sets. Here, we investigate the impact of the context of genetic and epigenetic alterations and tumor type on the classification and report on technical aspects, such as robustness of cutoff definition and preprocessing of the data. The association between gene copy number variation, predicted MGMT methylation, and MGMT expression revealed a gene dosage effect on MGMT expression in lower grade glioma (World Health Organization grade II/III) that in contrast to glioblastoma usually carry two copies of chromosome 10 on which MGMT resides (10q26.3). This implies some MGMT expression, potentially conferring residual repair function blunting the therapeutic effect of alkylating agents. A sensitivity analyses corroborated the performance of the original cutoff for various optimization criteria and for most data preprocessing methods. Finally, we propose an R package mgmtstp27 that allows prediction of the methylation status of the MGMT promoter and calculation of appropriate confidence and/or prediction intervals. Overall, MGMT-STP27 is a robust model for MGMT classification that is independent of tumor type and is adapted for single sample prediction

Sensory analysis of heated sodium alginate film flavored with chicken stock

The spread of non-communicable diseases (NCD) is considered one of the top health problems worldwide. A low intake of fruits and vegetables in conjunction with a high consumption of foods rich in saturated and trans fats, salt and sugar has been reported to be the main cause of a considerable proportion of deaths associated to NCDs (World Health Organization (WHO), 2009; WHO, 2011). NCD Global Action Plan 2013?2020 proposes, among other objectives, to reduce the impact of diabetes, giving priority to actions to prevent overweight and obesity (WHO, 2016). For this reason, interventions aiming at encouraging people to engage in healthier eating habits have been identified as one of the top priorities for reducing the burden of NCD (Beaglehole et al., 2011). To assist in the achievement of these objectives, an alternative for roasted chicken skin was proposed in the research carried out by Báez et al. (2017). In this work, a heat treated calcium alginate dry film prepared with chicken stock was developed. This film presented similar characteristics to roasted chicken skin when it was heated. Heat treatment of the dry film for 15 min at 130 °C produced the development of an opaque maroon color and an increased in their brittleness. This information can be used by product developers, culinary scientists and professional chefs in designing food products in which these kinds of films are employed to wrap or cover the top of chicken meat pieces that are then subjected to cooking. These studies suggest a potential use of heat treated-chicken stock films as a substitute of roasted chicken skin since the crisp texture and optical properties were alike. This is the basis for the preparation of healthier alternatives to the traditional roasted skin through reduction unhealthy components, such as fat (including cholesterol) and carcinogenic compounds, without loss of overall flavor intensity (Báez et al., 2017). However, sensory studies are needed before the product can be recommended.Fil: Delorenzi, Nestor Jorge. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Tecnología; ArgentinaFil: Busti, Pablo Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Tecnología; ArgentinaFil: Llopart, Emilce Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Tecnología; ArgentinaFil: Báez, Germán David. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Verdini, Roxana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentin

Rgtsp: a generalized top scoring pairs package for class prediction

Summary: A top scoring pair (TSP) classifier consists of a pair of variables whose relative ordering can be used for accurately predicting the class label of a sample. This classification rule has the advantage of being easily interpretable and more robust against technical variations in data, as those due to different microarray platforms. Here we describe a parallel implementation of this classifier which significantly reduces the training time, and a number of extensions, including a multi-class approach, which has the potential of improving the classification performance. Availability and Implementation: Full C++ source code and R package Rgtsp are freely available from http://lausanne.isb-sib.ch/~vpopovic/research/. The implementation relies on existing OpenMP libraries. Contact: [email protected]

PD-1⁺ Tcf1⁺ CD8⁺ T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure.

Virus-specific PD1 <sup>+</sup> Tcf1 <sup>+</sup> memory-like CD8 <sup>+</sup> T cells (T <sub>ML</sub> s) maintain the CD8 <sup>+</sup> T cell response during chronic viral infection. However, the fate of these cells following cessation of persistent antigen exposure has been unclear. Here, we find that T <sub>ML</sub> s persist upon transfer into antigen-free hosts and form memory following recall stimulation. Phenotypic, functional, and transcriptome analyses show that T <sub>ML</sub> -derived memory cells resemble those arising in response to acute, resolved infection, but they retain features of chronically stimulated cells, including elevated PD-1 and Tox and reduced cytokine expression. This chronic infection imprint is largely accounted for by constitutive Tox expression. Virus-specific Tcf1 <sup>+</sup> CD8 <sup>+</sup> T cells that persist after clearance of systemic infection also display a chronic infection imprint. Notwithstanding, renewed virus exposure induces a recall response, which controls virus infection in part. Thus, cessation of chronic antigen exposure yields a memory CD8 <sup>+</sup> T cell compartment that reflects prior stimulation

Ex fumo lucem. Giorgio Fossati, Francesco Fontebasso e una raccolta di modelli per camini

Il contributo si sofferma su un libro di modelli oggi poco conosciuto, i "Varij disegni de camini de gabineti" dell’architetto e incisore ticinese Giorgio Fossati (1705-1785), edito a Venezia anteriormente al 1740. La raccolta, che si ispira alle numerose opere francesi in materia, testimonia della ricezione in ambito lagunare del più aggiornato gusto internazionale. In certa misura, inoltre, viene ad anticipare le Diverse maniere d’adornare i cammini (1769) di Giambattista Piranesi, maestro che gli studi più recenti pongono in rapporto con Fossati giustappunto nel corso del quinto decennio del secolo. Oltre a far noto un camino corrispondente a un disegno incluso nel volumetto calcografico, esistente in una sala di palazzo Contarini a San Beneto, il testo indaga le relazioni intercorse tra Fossati e il pittore Francesco Fontebasso, che, pur non dichiarando il proprio intervento, collaborò come peintre-graveur all’esecuzione di alcune delle dodici tavole che compongono la silloge

Giancarlo Brasca e l'Università Cattolica: la biografia del primo direttore amministrativo nelle carte conservate dall'Ateneo

La ricerca prende avvio dagli anni giovanili, vissuti da Giancarlo Brasca nel contesto dei rami giovanili dell’Azione Cattolica ambrosiana. Il primo capitolo si propone di ricostruire quale clima e quali personalità abbiano influito sulle scelte effettuate dal giovane Brasca. Da questo punto di vista particolare attenzione è stata dedicata al rapporto con padre Agostino Gemelli e con monsignor Francesco Olgiati. L’intensità del legame con i due protagonisti del mondo cattolico milanese del Novecento costituisce un elemento significativo anche nella scelta vocazionale che legò Brasca ai Missionari della regalità di Nostro Signore Gesù Cristo, Istituto secolare fondato da Gemelli. Il secondo capitolo della tesi si prefigge dunque di ricostruire il significato dell’adesione di Brasca alla proposta di vita dei Missionari e l’apporto da lui fornito alle vicende dell’Istituto e all’evoluzione dei rapporti di quest’ultimo con l’Università Cattolica. La scelta vocazionale di Brasca rappresenta infatti la chiave di lettura imprescindibile per comprendere e ricostruire le vicende di Brasca all’interno dell’Università Cattolica dai primi anni Quaranta fino alla sua scomparsa nel 1979. Il terzo e il quarto capitolo ricostruiscono dunque le vicende di Brasca sullo sfondo degli snodi fondamentali che segnarono lo sviluppo dell’ateneo: dalla laurea in Filosofia, passando per l’esperienza di direttore della Biblioteca, per giungere agli incarichi amministrativi di primissimo piano come segretario di amministrazione e, dal 1971, direttore amministrativo.The research begins from the years of one’s youth, lived by Giancarlo Brasca in the contest of Azione Cattolica’s young lines in Milan. First chapter proposes to reconstruct which atmosphere and which personalities influenced young Brasca’s choices. On this point of view particular attenction was dedicated to relation with Father Agostino Gemelli and Monsignor Francesco Olgiati. The intensity of relationship with two protagonists of catholic world in Milan represents a significant fact also in vocational choice that binded Giancarlo Brasca with Missionari della regalità di Nostro Signore Gesù Cristo, secular institution founded by Gemelli. So second chapter of dissertation proposes to reconstruct the meaning of Brasca’s adhesion to Missionari’s life proposal, his contribution to story of institution and to development of relation between this and Catholic University. Brasca’s vocational choice represents indeed a necessary keynote to understand and reconstruct Brasca’s story in Catholic University from ’40 to his death in 1979. So third and fourth chapters reconstruct Brasca’s events on the contest of Catholic University: from Philosophy degree moving to experience which director of Library, to arrive to very important administrative assignments like secretary of administration and, from 1971, administrative director

Leer y escribir en la formación de grado: una construcción colectiva

Se socializa en este artículo una investigación desarrollada en la Formación de Docentes en el nivel no uni­ver­sitario, referida a procesos de lectura y escritura en dicho nivel. Investigación desarrollada durante tres años, en la cátedra Psicología y Cultura en la Educación, correspondiente al primer año de los profesorados de Lengua, Educación Física, Artes Visuales, Inglés y Matemática. Se ha partido de la idea de comprender a la educación, esencialmente, como el desarrollo de una compren­sión compartida, desde una perspectiva mutua (Edwarsds, Mercer, 1987, p. 13). Asimismo se consideró que, la formación de los futuros docentes requiere de las prácticas de lectura y escritura, como un elemento central a su futuro rol profesional. Y que la lectura y la escritura exigidas en el nivel superior se aprenden en ocasión de enfrentar las prácticas de producción discursiva y consulta de textos propios de cada materia, y según las posibilidades de recibir orientación y apoyo por parte de quien domina la materia y participa de prácticas lectoescritoras. (Carlino, 2005, p. 22). Reforzando esta perspectiva las características y las condiciones con que los futuros docentes ingresan a la formación de grado, en lo que refiere a competencias mínimas de lecto-escritura. El rol del docente formador se erige como tutor de los procesos de lecto-escritura de los futuros docentes, quienes son comunicados sobre qué y para qué leer y escribir en la formación. Y la necesidad de entender a la escritura y la lectura como procesos de construcción colectiva e individual, en los cuales el error es parte fundante de dichos procesos