204 research outputs found

    Giving Up the World for an Image

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    No abstract availableThis article was originally published by Parallel Press, an imprint of the University of Wisconsin-Madison Libraries, as part of The International Journal of Screendance, Volume 2 (2012), Parallel Press. It is made available here with the kind permission of Parallel Press

    Access To N-Based Heterocycles Via Sustainable Approaches

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    The main driving force in the development of new procedures for the construction of nitrogen heterocycles is represented by their ubiquity. Indeed, this class of organic scaffolds is frequently encountered in natural and synthetic bioactive products, agrochemicals and materials. The formation of new C–N bonds is one of the most fertile fields of research in organic chemistry, and a plethora of approaches are pursued for this goal. However, traditional strategies often suffer from having a negative impact on the environment. The use of hazardous solvents, noble metals, high temperatures and waste-producing methods is very common, although none of those features is aligned with the principles of green chemistry. Considering the ever-rising concerns regarding the conditions of the environment we live in, the urge to develop eco-friendly techniques is undeniable. During this PhD course, the goal of developing sustainable methods for the synthesis of various N-heterocycles has been achieved. This thesis reports the results of four methodology works (three of which have been published, and one will be submitted soon), in which the accessed scaffolds are: • azacarbolines, via an intramolecular oxidative cyclization of α-indolyl-hydrazones promoted by PhIO2, an iodine (V) reagent; • pyrrolo[2,3-b]indoles, obtained by the intramolecular oxidative amination of α-indolyl-hydrazones catalyzed by a combination of Cu (II) and Fe(III) salts in water as the sole solvent; • 1-aminoindoles, prepared by treating α-anilinyl-hydrazones with PIFA, an iodine (III) reagent; • and 1-aminopyrroles, via a formal FeIII-catalyzed [3 + 2] cyclodimerization of 1,2-diaza-1,3-dienes

    Proposing guidelines for responsible person eligibility in Malta

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    OBJECTIVES: To assess the current training and further education available to prospective Responsible Persons (RPs), to gather feedback from current RPs and industry stakeholders’ experiences and to recommend guidelines on what training and experience prospective RPs should undergo to become eligible for the role. METHOD: A focus group was organised with key stakeholders from the industry including representatives from the Medicines Authority, University of Malta and the Central Procurement and Supplies Unit (CPSU). Feedback on individual experiences was gathered. KEY FINDINGS: The most common recommendation from the focus group was the emphasis on the importance of having practical experience relative to the size and complexity of the operation. CONCLUSION: Guidelines to be proposed for a framework on accepting RPs should consider experience supported by knowledge on obligations and duties to be fulfilled by the RP.peer-reviewe

    Human vs non-human bone: identification and differentiation of fragmented skeletal remains using non-destructive methods

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    © Cranfield University, 2018Fragmented human and non-human bones can be found in forensic contexts, such as mass disasters, mass graves, and crime scenes, as well as in archaeological deposits. When fragmented skeletal remains are found, one of the first questions asked is whether or not the fragments are human or non- human. If none of the diagnostic features is visible, the origin of the fragments may be difficult to assess. Most of the methods currently employed to identify the origin of bone fragments, such as microscopic and biomolecular methods, are invasive and time consuming. The aim of the research presented in this thesis was to explore the potential of non-destructive procedures, such as GIS (Geographic Information System) software, morphological examination and Micro-Computed Tomography, in determining whether or not a bone fragment is human. These techniques were applied on skeletal features not commonly used for the human-nonhuman bone differentiation. Cranial suture patterns, cranial curvature and rib shaft curvature were assessed and measured using a GIS software. In addition, the morphology of the occipital condyles and the linea aspera of the femur were investigated and compared between human and non-human species. Finally, primary nutrient foramina and cross-sectional shape of long bones were analysed using micro-CT. More than 700 human and non-human bones were used; the non-human species selected are the ones whose remains are likely to be found in forensic or archaeological contexts in the United Kingdom. Most of the bone features considered and the procedures used in this study proved to be reliable for the differentiation between human and non-human fragmented bones. Blind tests performed on fragments whose human or non-human origin was not known further demonstrated the applicability and effectiveness of the methods and features explored in this study. The results of this research provide a valuable contribution to the fields of forensic anthropology, bioarchaeology, and comparative anatomy

    Companion and free-ranging Bali dogs: Environmental links with personality traits in an endemic dog population of South East Asia

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    Dogs living on Bali Island have been free-ranging for thousands of years. A large group of expatriates sometimes adopt Bali dogs and keep them restricted to their houses and backyards, as is typical in modern western cultures. This provides us with the unique opportunity to compare the personality traits of dogs to their lifestyle either living as human companions or as free-ranging animals, exploring at the same time the impact of demographic variables (such as age, sex, and neutered status) on personality. After controlling for internal consistency of the scales and between-observer variation, we found that free-ranging Bali dogs were rated as less active, less excitable, less aggressive towards animals, and less inclined to chase animals or humans than Bali dogs living as human companions. Among free-ranging dogs, females were found to be more excitable. Females in the whole sample were also more fearful of people. The results of this preliminary study suggest that a change in lifestyle, i.e. being adopted, and living in a confined environment has negative consequences on some canine personality traits, such as activity/excitability, aggression towards animals, and prey drive

    La dispersión de la identidad corporativa como generadora de problemas comunicacionales y organizacionales

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    La gestión comunicacional es transmisora de mensajes y generadora de imágenes en los diferentes públicos de la sociedad. Sean personas naturales o jurídicas (organizaciones), la comunicación parte necesariamente de la existencia de una base común: la identidad. La identidad corporativa, entendida como el conjunto de elementos empresariales, organizacionales, operacionales y de comportamiento compartidos por los miembros de una institución tiene que administrarse, pues solo con esta labor es que adquiere y genera valor; es decir, cumple su labor de activo intangible. Contrariamente, la ausencia de gestión permite la aparición de un fenómeno frecuente, pero hasta ahora no conceptualizado: la dispersión. El presente trabajo propone un marco teórico en torno a lo que es, cómo se genera y algunas formas en las que se presenta la dispersión de la identidad corporativa, situaciones de las cuales se derivan una serie de problemas comunicacionales y organizacionales que, de no haber una intervención para su solución, pueden convertirse en fallas estructurales que afectarían tanto el desarrollo como las actividades de la organización
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