Solutions to axion electrodynamics in various geometries

Recently there has been a surge of new experimental proposals to search for ultralight axion dark matter with axion mass, m_{a}≲1  μeV. Many of these proposals search for small oscillating magnetic fields induced in or around a large static magnetic field. Lately, there has been interest in alternate detection schemes which search for oscillating electric fields in a similar setup. In this paper, we explicitly solve Maxwell’s equations in a simplified geometry and demonstrate that in this mass range, the axion-induced electric fields are heavily suppressed by boundary conditions. Unfortunately, experimentally measuring axion-induced electric fields is not feasible in this mass regime using the currently proposed setups with static primary fields. We show that at larger axion masses, induced electric fields are not suppressed, but boundary effects may still be relevant for an experiment’s sensitivity. We then make a general argument about a generic detector configuration with a static magnetic field to show that the electric fields are always suppressed in the limit of large wavelength.National Science Foundation (U.S.) (Award No. 1806440

Novel mechanisms of eIF2B action and regulation by eIF2alpha phoshorylation

Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric G-protein that plays a critical role in protein synthesis regulation. eIF2-GTP binds Met-tRNAi to form the eIF2-GTP:Met-tRNAi ternary complex (TC), that is recruited to the 40S ribosomal subunit. Following GTP hydrolysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B. Phosphorylation of the eIF2α subunit in response to various cellular stresses converts eIF2 into a competitive inhibitor of eIF2B, triggering the integrated stress response. Dysregulation of eIF2B activity is associated with a number of pathologies, including neurodegenerative diseases, metabolic disorders, and cancer. However, despite decades of research, the underlying molecular mechanisms remain unknown. This is due in large part to the absence of a structural understanding of the eIF2B assembly and of the eIF2B:eIF2 interaction. Common methods, such as yeast genetics, have been unable to unambiguously determine these mechanisms. Meanwhile, expanded interest in the integrated stress response has uncovered a diverse array of pathologies for which therapeutic modulation of the eIF2B:eIF2 interaction may ameliorate or overcome disease states. In this dissertation, a combination of structural and biochemical techniques is employed to elucidate the mechanisms of eIF2B action and its regulation by eIF2α phosphorylation. The aim is to provide a direct, unambiguous, structural understanding of eIF2B assembly and of eIF2B’s interactions with phosphorylated and unphosphorylated eIF2α. The work described here was among the first to challenge the widely held notion of a pentameric eIF2B assembly, as eventually confirmed by the recent publication of eIF2B’s crystal structure. The work further aims to overturn another long-standing assumption regarding the nature of inhibition of eIF2B activity: that competitive inhibition is mediated by a “direct effect” of the negatively charged phosphate group on the eIF2α:eIF2B interaction. Instead, we present evidence for an “indirect effect,” whereby phosphorylation disrupts a novel intramolecular interface within eIF2α, exposing an eIF2α surface that binds eIF2B and is responsible for inhibition of eIF2B. In the end, we combine a structural model of the eIF2B:eIF2 complex with our novel mechanism of inhibition, placing them within the larger thermodynamic context of eIF2-GDP recycling by eIF2B.2017-09-08T00:00:00

Guest Recital: Julia Bogorad, Flute

Kemp Recital Hall Thursday Evening April 8, 1993 6:30p.m

Intraocular Lens Implant Image Quality: The Optico-Retinal Interface

Improvements in intraocular lens implants during the past ten years have revolutionized cataract surgery. Both anterior and posterior chamber lenses are currently in wide use, but the optical superiority of the posterior chamber location has yet to be demonstrated. To do so, a more detailed analysis is required of visual function than is clinically routine. Also required is appreciation that the retina is an integral part of the eye\u27s optical system because of its directional characteristics, which are known as the Stiles-Crawford effect. The optical quality of the pseudophakic eye is affected by the optics of the implant, its centration, and its anteroposterior position. Contrast sensitivity measurements in numerous pseudophakic patients are therefore necessary to determine the actual differences of in situ optical performances among different types of lens implants

Detecting Spam Publishers By Serving Honeypot Ads

Click fraud, wherein bots or other unauthorized users click on ads to falsely inflate click-through rates, is a major problem in the online ad industry. This disclosure describes a type of ad, known as a honeypot ad, that is not particularly attractive to humans, but for bots is indistinguishable from a genuine ad. Publishers who employ bots to fraudulently inflate click-through rates, or to misrepresent the popularity of their app or website, are detected when the number of clicks on such honeypot ads are substantially larger than the number of clicks on genuine ads

The effects of space radiation on thin films of YBa2Cu3O(sub 7-x)

This investigation had two objectives: (1) to determine the effects of space radiation on superconductor parameters that are most important in space applications; and (2) to determine whether this effect can be simulated with Co-60 gamma rays, the standard test method for space materials. Thin films of yttrium barium copper oxide (YBCO) were formed by coevaporation of Y, BaF2, and Cu and post-annealing in wet oxygen at 850 C for 3.5 h. The substrate used was (100) silicon with an evaporated zirconia buffer layer. The samples were characterized by four point probe electrical measurements as a function of temperature. The parameters measured were the zero resistance transition temperature (T sub c) and the room temperature resistance. The samples were then exposed to Co-60 gamma-rays in air and in pure nitrogen, and to 780 keV electrons, in air. The parameters were then remeasured. The results are summarized. The results indicate little or no degradation in the parameters measured for samples exposed up to 10 Mrads of gamma-rays in nitrogen. However, complete degradation of samples exposed to 10-Mrad in air was observed. This degradation is preliminarily attributed to the high level of ozone generated in the chamber by the gamma-ray interaction with air. It can be concluded that: (1) the electron component of space radiation does not degrade the critical temperature of the YBCO films described, at least for energies around 800 keV and doses similar to those received by surface materials on spacecraft in typical remote sensing missions; and (2) for qualifying this and other superconducting materials against the space-radiation threat the standard test method in the aerospace industry, namely, exposure to Co-60 gamma-rays in air, may require some further investigation. As a minimum, the sample must be either in vacuum or in positive nitrogen pressure

Coherent Self-Interactions of Dark Matter in the Bullet Cluster

Many models of dark matter include self-interactions beyond gravity. A variety of astrophysical observations have previously been used to place limits on the strength of such self-interactions. However, previous works have generally focused either on short-range interactions resulting in individual dark matter particles scattering from one another, or on effectively infinite-range interactions which sum over entire dark matter halos. In this work, we focus on the intermediate regime: forces with range much larger than dark matter particles' inter-particle spacing, but still shorter than the length scales of known halos. We show that gradients in the dark matter density of such halos would still lead to observable effects. We focus primarily on effects in the Bullet Cluster, where finite-range forces would lead either to a modification of the collision velocity of the cluster or to a separation of the dark matter and the galaxies of each cluster after the collision. We also consider constraints from the binding of ultrafaint dwarf galaxy halos, and from gravitational lensing of the Abell 370 cluster. Taken together, these observations allow us to set the strongest constraints on dark matter self-interactions over at least five orders of magnitude in range, surpassing existing limits by many orders of magnitude throughout.Comment: 10 pages, 2 figure