Jet Production in Association with Vector Bosons or Top Quarks

The LHC experiments ATLAS and CMS have measured V+jets and ttbar+jets final states over a large energy range in data collected between 2010 and 2012 at sqrt(s) = 7 TeV and sqrt(s) = 8 TeV. The results have been compared to pQCD calculations at NLO and have been used to validate novel Monte Carlo techniques

Effects of deep vertical placement of lime on corn and soybean response and soil chemical properties in conservation tillage systems

Abstract from introductionSoil acidity is one of the most influential factors in limiting crop production around the world. Roughly 30% of the Earth's total land area and as much as 70% of potentially farmable land is affected by soil acidity (Rengel, 2003). Soil acidity is common worldwide and can be found across almost all soil orders. However, acidity occurs predominantly in soils formed from acidic parent material or areas where weathering has occurred over a long period of time, such as Oxisols, Ultisols, Alfisols and Andisols (Jayawardane and Stewart, 1995). As a soil naturally weathers in humid climates, it will often result in an increasingly acidic profile due to the loss of base cations. In addition to naturally occurring weathering, soils under degradative management practices will often lead to an increased in soil acidity (Adams, 1984). A highly weathered or degraded soil often results in an acidic soil environment with hard and infertile subsoils that prove to be resistant and sometimes impenetrable to plant roots (Sumner et al., 1986). Similar studies conducted by Marsh and Grove (1992) and Caires et al. (2008) found strong correlations between both corn (Zea mays L.) and soybean (Glycine max (L.) Merr.) root growth and yield response to soil acidity

Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors.

IntroductionThe interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis.MethodsHuman CD14+ cells were isolated from healthy donors, cultured on dentine slices and coverslips and stimulated with IL-17A and/or receptor activator of NF-kappaB ligand (RANKL). Osteoclast differentiation was evaluated by gene expression, flow cytometry, tartrate-resistant acid phosphatase staining, fluorescence and electron microscopy. Physiologic bone remodelling was studied in wild-type (Wt) and IL-17A-/- mice using micro-computer tomography and serum RANKL/osteoprotegerin concentration. Functional osteoclastogenesis assays were performed using bone marrow macrophages isolated from IL-17A-/- and Wt mice.ResultsIL-17A upregulates the receptor activator for NF-kappaB receptor on human osteoclast precursors in vitro, leading to increased sensitivity to RANKL signalling, osteoclast differentiation and bone loss. IL-17A-/- mice have physiological bone homeostasis indistinguishable from Wt mice, and bone marrow macrophages isolated from these mice develop fully functional normal osteoclasts.ConclusionsCollectively our data demonstrate anti-IL-17A treatment as a selective therapeutic target for bone loss associated with autoimmune diseases

LACIS/FAU/CDS/FGA-UnB : inovação e sustentabilidade

Os desafios do século XXI exigem que mudanças de paradigmas tecnológicos sejam aceleradas visando minimizar impactos ambientais e desperdícios de recursos naturais, e reduzir emissões e poluições. Entre as atividades mais impactantes no planeta cita-se a produção do ambiente construído que é resultado de processos da Cadeia Produtiva da Indústria da Construção (CPIC). O estudo da aceleração da mudança de paradigmas tecnológicos está vinculado ao estudo do processo de inovação. A compreensão dos vetores de influência no processo de inovação da CPIC requer estudos que identifiquem como novas idéias são geradas e integradas ao processo de produção e aos produtos, o que exige que modelos específicos sejam desenvolvidos e testados na prática por meio de projetos pilotos. Os estudos que visam identificar as forças responsáveis pelo surgimento das inovações e que demonstram, com mais profundidade, as relações entre os diferentes atores e os vetores de influência se tornam relevantes. Neste sentido, entre as contribuições que vêm sendo dadas no âmbito da Universidade Brasileira, cita-se o Laboratório do Ambiente Construído, Inclusão e Sustentabilidade (LACIS/UnB). O objetivo deste artigo é apresentar a trajetória do LACIS/ FAU/CDS/FGA-UnB nos últimos cinco anos e os principais resultados da pesquisa aplicada à criação, teste e compartilhamento de tecnologias, metodologias e conhecimento com foco na cadeia produtiva da indústria da construção, gestão integrada de resíduos sólidos e processos regenerativos sociais e urbanos. A apresentação do processo evolutivo do LACIS requer a demonstração dos princípios teóricos que fundamentam a sua evolução, as origens e etapas do seu desenvolvimento e os resultados dos projetos de pesquisa aplicada. ______________________________________________________________________________________ ABSTRACTThe twenty-first century challenges require the acceleration of the technological paradigms changes in order to minimize environmental impacts and waste of natural resources, and reduce emissions and pollution. Among the main impactful activities on the planet quotes the production of the built environment which is a result of the processes of the productive chain of the construction industry (PCCI). The study of the acceleration of technological paradigm shift is linked to the study of the innovation process. The understanding of the influence vectors of the innovation process of PCCI requires studies that identify how new ideas are generated and integrated into the production process and products. These studies require the development of specific models which must be tested in practice through pilot projects. Studies aimed at identifying forces responsible for the emergence of innovations and demonstrating the relations between different actors and vectors of influence become relevant. In this sense, among the contributions that are being given in the University of Brasilia it can be quoted the Lacis/UnB. The aim of this paper is to present the trajectory of Lacis/FAU/CSD/FGA-UNB in the last five years and the main results of applied research with a focus on the productive chain of the construction industry, integrated management of solid waste and regenerative urban and social processes. A presentation of the Lacis evolutionary process requires the demonstration of theoretical principles that underlie its evolution, the origins and stages of its development and the results of the applied research projects

PAR13: HYPOTHETICAL VERSUS REAL WILLINGNESS TO PAY IN THE HEALTH CARE SECTOR: RESULTS FROM A FIELD EXPERIMENT

How does the brain carry out working memory storage, categorization, and voluntary performance of event sequences? The LIST PARSE neural model proposes an answer to this question that unifies the explanation of cognitive, neurophysiological, and anatomical data from humans and monkeys. It quantitatively simulates human cognitive data about immediate serial recall and free recall, and monkey neurophysiological data from the prefrontal cortex obtained during sequential sensory-motor imitation and planned performance. The model clarifies why both spatial and non-spatial working memories share the same type of circuit design. It proposes how the laminar circuits of lateral prefrontal cortex carry out working memory storage of event sequences within layers 6 and 4, how these event sequences are unitized through learning into list chunks within layer 2/3, and how these stored sequences can be recalled at variable rates that are under volitional control by the basal ganglia. These laminar prefrontal circuits are variations of laminar circuits in the visual cortex that have been used to explain data about how the brain sees. These examples from visual and prefrontal cortex illustrate how laminar neocortex can represent both spatial and temporal information, and open the way towards understanding how other behaviors may be represented and controlled by variations on a shared laminar neocortical design.National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624, N00014-95-1-0409

Phase I clinical trial evaluating the safety and efficacy of ADP-A2M10 SPEAR T cells in patients with MAGE-A10+ advanced non-small cell lung cancer

BACKGROUND: ADP-A2M10 specific peptide enhanced affinity receptor (SPEAR) T cells (ADP-A2M10) are genetically engineered autologous T cells that express a high-affinity melanoma-associated antigen A10 (MAGE-A10)-specific T-cell receptor (TCR) targeting MAGE-A10 METHODS: Eligible patients were HLA-A*02 positive with advanced NSCLC expressing MAGE-A10. Patients underwent apheresis; T cells were isolated, transduced with a lentiviral vector containing the TCR targeting MAGE-A10, and expanded. Patients underwent lymphodepletion with varying doses/schedules of fludarabine and cyclophosphamide prior to receiving ADP-A2M10. ADP-A2M10 were administered at 0.08-0.12×10 RESULTS: Eleven patients (male, n=6; female, n=5) with NSCLC (adenocarcinoma, n=8; squamous cell carcinoma, n=3) were treated. Five, three, and three patients received cells in dose group 1, dose group 2, and dose group 3/expansion, respectively. The most frequently reported grade ≥3 adverse events were lymphopenia (n=11), leukopenia (n=10), neutropenia (n=8), anemia (n=6), thrombocytopenia (n=5), and hyponatremia (n=5). Three patients presented with cytokine release syndrome (grades 1, 2, and 4, respectively). One patient received the highest dose of lymphodepletion (fludarabine 30 mg/m CONCLUSIONS: ADP-A2M10 demonstrated an acceptable safety profile and no evidence of toxicity related to off-target binding or alloreactivity. There was persistence of ADP-A2M10 in peripheral blood as well as ADP-A2M10 trafficking into the tumor. Given the discovery that MAGE-A10 and MAGE-A4 expression frequently overlap, this clinical program closed as trials with SPEAR T cells targeting MAGE-A4 are ongoing