MANAGING CONFLICT IN SOCIAL SPHERE OF LABOUR

The article presents a model of problem-solving training in new technologies, methods of tracking the demand of multi-functional groups on the basis of a temporary type ofspecially designed subsystems for knowledge management. On the basis ofdiagnostic test characteristics are determined by the prevailing educational methods for sustainable conflict-free development, and analyzes the degree of interactivity, and, as a general result that gives a holistic view of the process of self-organization for innovation development

Genesis of categories of quality and standard of living: methodological issues

The article analyzes the concept of categories of quality and standard of living. We propose a series of quality control that characterize specific functions, dynamics, and the results of the processes of adaptation and development in the context of special adaptive mechanism. The elements of the adaptive mechanism speaking standard and new special features, performance and control elements of quality and standards of living

Models and functions of the control mechanism cost effectiveness of innovative development enterprises in the complex of economic facilities knowledge: organizational design methods

Organizational design of processes of functioning of the mechanism forеsight-controlling with the expected controlling properties of regulation of stability of development of the enterprises is caused by requirements of economy in the conditions of the growing uncertainty of the environment. Improvement of quality of regulation of profitability is directed to improvement of interaction of the enterprises with complex objects. Combination of design approach to development of the mechanism with processes of organizational design of procedures of its assessment and adjustment is necessary. Therefore, the research objective determined development of methods of organizational design of the decision-making processes defining structures, functions of coordination and control of results of regulation of parameters of quality of the mechanism of forеsight-controlling. The scientific novelty of a research is presented by the following methods: combination of design and process approaches to improvement of quality of interaction in a complex; development of the theory of management in the concept of combination of the principles of functioning of mechanistic and organic models of organizational design of the mechanism; formation of digital simulators of regulators of the mechanism according to the principles of integration and combination of approaches. The concept differs in new opportunities of use of the mechanism of forеsight-controlling. Preventive assessment of influences of regulators by results of monitoring of indicators of profitability in a zone of sustainable innovative development of the enterprise for criterion of a compromise of the purposes of profitability and innovation, centralization and specialization of processes of functioning is provided. On the basis of the developed standards of quality of regulation and reliability of their forecasts the following practical results at the enterprise object of a research are received: the algorithmic scheme of development and realization of digital model of organizational design and functioning of the mechanism of forеsight-controlling is created; the adjustability of processes of increase in profitability by specialized criteria of stability of development at stages of an innovative cycle of the enterprise is provided; the assessment of the actual indicators of quality on the basis of examination of initial parameters of quality of regulation is carried out; by results of mathematical modeling of the digital simulator of the mechanism of forеsight-controlling recommendations about correction of planned and target indicators of quality of formation of development strategies taking into account factors of economy of knowledge are developed; organizational and behavioural and economic indicators of strategy of functioning of an object with use of the mechanism of forеsight-controlling are defined. Continuation of researches is supposed in the directions of improvement of systems of post-industrial agglomeration of the region and country with use of mechanisms of forеsigh-controlling in complexes of organizational and power technological purpose. Monitoring of factors provides combination of resources of low carbon and “green” power that promotes transformation of grounds of waste as a part of a complex in power sources and zones of absorption of carbon dioxide

Models and functions of the mechanism for regulating the efficiency of innovative development of an enterprise in the complex of objects of the knowledge economy: theoretical and methodological foundations for the formation

The relevance of improving the theory of management in terms of indicators of economic efficiency of innovative development of enterprises is justified by the needs of high-tech industry. Mechanisms are needed to regulate the imbalance of their goals of economy and innovation using the resources of educational and scientific objects. The lack of monitoring of factors of the knowledge economy, the functioning of enterprises outside the complex of its facilities exacerbates the problems of imbalance of goals. The insufficient quality of interaction regulation in the complex determined the goal of developing new models of the theory and methodology for the formation of a mechanism with predictive and controlling properties of assessing and regulating target quality indicators of the functions of managing the economy of innovative development of enterprises. The theory model is represented by the system elements of the decomposition of the object of study, analysis of functions and structures of the mechanism for regulating the relationships of enterprises in the complex. The theory justifies the procedures of the methodology for the synthesis of the forsite-controlling mechanism of predicted indicators of the economy and initialization of enterprises based on the results of monitoring environmental factors. Theoretical and methodological foundations define a multivariable approach to the formation of a mechanism and the organizational design of its functioning processes in methodical part of the study. The approach is implemented in the concept of integrating the functions of foresight management and controlling the goals of economy and innovation of enterprise development in a complex using additional management functions. The novelty of the study is presented by the following results: concepts of theory are proposed that take into account the peculiarities of the processes of regulating the cost-effectiveness of innovative development of enterprises in the mechanism; development of models and functions for management of integration and combination of complex resources in innovative cycles of enterprises; external and internal environment monitoring subsystem is formed; modernized stability criteria, which determine the adjustment of the quality of functions in digital simulators of speed controllers of the mechanism for matching standard and additional functions; An expanded system of balanced indicators is justified, characterized by the stability of the results of regulating the imbalance of individual and group interests within the individual enterprise and their combination; mathematical models of evolutionary and hopping processes for forming a digital mechanism simulator are adapted. Scientific results make it possible to substantiate indicators of quality of regulation of cost-effectiveness of innovative development and to supplement planning tools in the methodological part of the study of the mechanism functioning processes and the algorithmic scheme of the digital model. The system of balanced indicators is implemented in the new structure Center for digital coordination of interests of complex facilities of the and the system of post-industrial agglomeration of the region

Managing conflict in social sphere of labour

The article presents a model of problem-solving training in new technologies, methods of tracking the demand of multi-functional groups on the basis of a temporary type ofspecially designed subsystems for knowledge management. On the basis of diagnostic test characteristics are determined by the prevailing educational methods for sustainable conflict-free development, and analyzes the degree of interactivity, and, as a general result that gives a holistic view of the process of self-organization for innovation development

Intracellular DNA Damage by Lysine-Acetylene Conjugates

Previously, we reported the design and properties of alkyne C-lysine conjugates, a powerful and tunable family of DNA cleaving reagents. We also reported that, upon photoactivation, these molecules are capable of inducing cancer cells death. To prove that the cell death stems from DNA cleavage by the conjugates, we investigated intracellular DNA damage induced by these molecules in LNCap cancer cells using single cell gel electrophoresis (SCGE) assays. The observation of highly efficient DNA damage confirmed that lysine acetylene conjugate is capable of cleaving the densely compacted intracellular DNA. This result provides a key mechanistic link between efficient DNA cleavage and cytotoxicity towards cancer cells for this family of light-activated anticancer agents

Disulfides – Effective radical generators for flame retardancy of polypropylene

The potential of thirteen aliphatic, aromatic, thiuram and heterocyclic substituted organic disulfide derivatives of the general formula R-S-S-R’ as a new group of halogen-free flame retardants (FR) for polypropylene films have been investigated. According to DIN 4102-1 standard ignitibility test, for the first time it has been demonstrated that many of the disulfides alone can effectively provide flame retardancy and self-extinguishing properties to polypropylene (PP) films at already very low concentrations of 0.5 wt%. In an effort to elucidate the mechanism of the thermal decomposition of disulfide derivatives the fragmentation patterns of the evolved gases from a thermogravimetric analyzer (TGA) have been analyzed by simultaneous mass spectrometry (MS) and Fourier transform infrared spectrometry (FTIR). The main decomposition products initiated by homolytic scission of the S-S bond and/or scission of the C-S bond were identified as thiols, aliphatic and aromatic hydrocarbons, isothiocyanates (depending on the disulfide structures) with further evolution of elemental sulfur and sulfur dioxide at temperatures of above 300 oC and 450 oC, respectively. Based on this preliminary study, we have shown that disulfides represented by e.g. diphenyl disulfide (1), 5,5'-dithiobis(2-nitrobenzoic acid) (2), bis(1-phenyl-1H-tetrazol-5yl)-disulfide (4), 2-bisbenzothiazole-2,2′-disulfide (6) and N,N-dithiobis-(phtalimide) (10) constitute a new halogen-free family of additives for flame retarding of polypropylene

Visible-light-driven metal-free C-H functionalization: access to new bioactive tetrahydroisoquinoline-butenolide hybrids via domino amine oxidation/vinylogous mannich reaction

An efficient metal-free visible-light-driven two-step domino reaction towards new bioactive tetrahydroisoquinoline-butenolide hybrid compounds was developed for the first time. The combination of fluorescein as photosensitizer and thiourea as an additive was found to be the most effective way to promote an aerobic amine oxidation/vinylogous Mannich domino reaction sequence with yields up to 97% for a broad substrate scope. Both experimental and computational evidence supported the crucial role of singlet oxygen in the developed C H functionalization reaction. Furthermore, the data suggest that thiourea is essential due to its ability to act as an electron-transfer mediator and/or scavenger of reactive oxygen species. In addition, in vitro studies of tetrahydroisoquinoline-butenolide hybrid compounds demonstrated their high antischistosomal and anti-cancer activities

Organocatalytic sulfoxidation

Treatment of a sulfide with a catalytic amount of a 1,3 diketone in the presence of silica sulfuric acid as a co-catalyst and hydrogen peroxide (50% aq) as the stoichiometric oxidant leads to the corresponding sulfoxide product. The reaction is effective for diaryl, aryl-alkyl and dialkyl sulfides and is tolerant of oxidisable and acid sensitive functional groups. Investigations have shown that the tris-peroxide 2, formed on reaction of pentane-2,4-dione with hydrogen peroxide under acidic reaction conditions, can oxidise two equivalents of sulfide using the exocyclic peroxide groups whereas the endocyclic peroxide remains intact. Calculations provide a mechanism consistent with experimental observations and suggest the reaction proceeds via an initial acid catalysed ring opening of a protonated tris-peroxide prior to oxygen transfer to a sulfur nucleophile