First Light of Engineered Diffusers at the Nordic Optical Telescope Reveal Time Variability in the Optical Eclipse Depth of WASP-12b

We present the characterization of two engineered diffusers mounted on the 2.5 meter Nordic Optical Telescope, located at Roque de Los Muchachos, Spain. To assess the reliability and the efficiency of the diffusers, we carried out several test observations of two photometric standard stars, along with observations of one primary transit observation of TrES-3b in the red (R-band), one of CoRoT-1b in the blue (B-band), and three secondary eclipses of WASP-12b in V-band. The achieved photometric precision is in all cases within the sub-millimagnitude level for exposures between 25 and 180 seconds. Along a detailed analysis of the functionality of the diffusers, we add a new transit depth measurement in the blue (B-band) to the already observed transmission spectrum of CoRoT-1b, disfavouring a Rayleigh slope. We also report variability of the eclipse depth of WASP-12b in the V-band. For the WASP-12b secondary eclipses, we observe a secondary-depth deviation of about 5-sigma, and a difference of 6-sigma and 2.5-sigma when compared to the values reported by other authors in similar wavelength range determined from Hubble Space Telescope data. We further speculate about the potential physical processes or causes responsible for this observed variabilityComment: 11 pages, 9 figure

Transmission spectroscopy of the inflated exo-Saturn HAT-P-19b

We observed the Saturn-mass and Jupiter-sized exoplanet HAT-P-19b to refine its transit parameters and ephemeris as well as to shed first light on its transmission spectrum. We monitored the host star over one year to quantify its flux variability and to correct the transmission spectrum for a slope caused by starspots. A transit of HAT-P-19b was observed spectroscopically with OSIRIS at the Gran Telescopio Canarias in January 2012. The spectra of the target and the comparison star covered the wavelength range from 5600 to 7600 AA. One high-precision differential light curve was created by integrating the entire spectral flux. This white-light curve was used to derive absolute transit parameters. Furthermore, a set of light curves over wavelength was formed by a flux integration in 41 wavelength channels of 50 AA width. We analyzed these spectral light curves for chromatic variations of transit depth. The transit fit of the combined white-light curve yields a refined value of the planet-to-star radius ratio of 0.1390 pm 0.0012 and an inclination of 88.89 pm 0.32 degrees. After a re-analysis of published data, we refine the orbital period to 4.0087844 pm 0.0000015 days. We obtain a flat transmission spectrum without significant additional absorption at any wavelength or any slope. However, our accuracy is not sufficient to significantly rule out the presence of a pressure-broadened sodium feature. Our photometric monitoring campaign allowed for an estimate of the stellar rotation period of 35.5 pm 2.5 days and an improved age estimate of 5.5^+1.8_-1.3 Gyr by gyrochronology.Comment: 14 pages, 9 figures, Accepted for publication in A&

Broad-band spectrophotometry of the hot Jupiter HAT-P-12b from the near-UV to the near-IR

The detection of trends or gradients in the transmission spectrum of extrasolar planets is possible with observations at very low spectral resolution. Transit measurements of sufficient accuracy using selected broad-band filters allow for an initial characterization of the atmosphere of the planet. We obtained time series photometry of 20 transit events and analyzed them homogeneously, along with eight light curves obtained from the literature. In total, the light curves span a range from 0.35 to 1.25 microns. During two observing seasons over four months each, we monitored the host star to constrain the potential influence of starspots on the derived transit parameters. We rule out the presence of a Rayleigh slope extending over the entire optical wavelength range, a flat spectrum is favored for HAT-P-12b with respect to a cloud-free atmosphere model spectrum. A potential cause of such gray absorption is the presence of a cloud layer at the probed latitudes. Furthermore, in this work we refine the transit parameters, the ephemeris and perform a TTV analysis in which we found no indication for an unseen companion. The host star showed a mild non-periodic variability of up to 1%. However, no stellar rotation period could be detected to high confidence.Comment: 13 pages, 6 figures, Accepted for publication in A&

Long-Term Optical Monitoring of Eta Carinae. Multiband light curves for a complete orbital period

The periodicity of 5.5 years for some observational events occurring in Eta Carinae manifests itself across a large wavelength range and has been associated with its binary nature. These events are supposed to occur when the binary components are close to periastron. To detect the previous periastron passage of Eta Car in 2003, we started an intensive, ground-based, optical, photometric observing campaign. We continued observing the object to monitor its photometric behavior and variability across the entire orbital cycle. Our observation program consisted of daily differential photometry from CCD images, which were acquired using a 0.8 m telescope and a standard BVRI filter set at La Plata Observatory. The photometry includes the central object and the surrounding Homunculus nebula. We present up-to-date results of our observing program, including homogeneous photometric data collected between 2003 and 2008. Our observations demonstrated that Eta Car has continued increasing in brightness at a constant rate since 1998. In 2006, it reached its brightest magnitude (V ~ 4.7) since about 1860s. The object then suddenly reverted its brightening trend, fading to V = 5.0 at the beginning of 2007, and has maintained a quite steady state since then. We continue the photometric monitoring of Eta Car in anticipation of the next "periastron passage", predicted to occur at the beginning of 2009.Comment: Accepted by A&A. The paper contains 3 figures and 2 table

Broad-band spectrophotometry of HAT-P-32 b: search for a scattering signature in the planetary spectrum

Multicolour broad-band transit observations offer the opportunity to characterize the atmosphere of an extrasolar planet with small- to medium-sized telescopes. One of the most favourable targets is the hot Jupiter HAT-P-32 b. We combined 21 new transit observations of this planet with 36 previously published light curves for a homogeneous analysis of the broad-band transmission spectrum from the Sloan u′ band to the Sloan z′ band. Our results rule out cloud-free planetary atmosphere models of solar metallicity. Furthermore, a discrepancy at reddest wavelengths to previously published results makes a recent tentative detection of a scattering feature less likely. Instead, the available spectral measurements of HAT-P-32 b favour a completely flat spectrum from the near-UV to the near-IR. A plausible interpretation is a thick cloud cover at high altitudes

Health-related quality of life in Huntington’s Disease patients: a comparison of proxy assessment and patient self-rating using the disease-specific Huntington’s Disease health-related quality of life questionnaire (HDQoL)

Huntington’s disease (HD) is a fatal, neurodegenerative disease for which there is no known cure. Proxy evaluation is relevant for HD as its manifestation might limit the ability of persons to report their health-related quality of life (HrQoL). This study explored patient–proxy ratings of HrQoL of persons at different stages of HD, and examined factors that may affect proxy ratings. A total of 105 patient–proxy pairs completed the Huntington’s disease health-related quality of life questionnaire (HDQoL) and other established HrQoL measures (EQ-5D and SF-12v2). Proxy–patient agreement was assessed in terms of absolute level (mean ratings) and intraclass correlation. Proxies’ ratings were at a similar level to patients’ self-ratings on an overall Summary Score and on most of the six Specific Scales of the HDQoL. On the Specific Hopes and Worries Scale, proxies on average rated HrQoL as better than patients’ self-ratings, while on both the Specific Cognitive Scale and Specific Physical and Functional Scale proxies tended to rate HrQoL more poorly than patients themselves. The patient’s disease stage and mental wellbeing (SF-12 Mental Component scale) were the two factors that primarily affected proxy assessment. Proxy scores were strongly correlated with patients’ self-ratings of HrQoL, on the Summary Scale and all Specific Scales. The patient–proxy correlation was lower for patients at moderate stages of HD compared to patients at early and advanced stages. The proxy report version of the HDQoL is a useful complementary tool to self-assessment, and a promising alternative when individual patients with advanced HD are unable to self-report

Chronic Obstructive Pulmonary Disease Patients Have Greater Systemic Responsiveness to Ex Vivo Stimulation with Swine Dust Extract and its Components Versus Healthy Volunteers

Chronic obstructive pulmonary disease (COPD) is characterized by an airway and systemic inflammatory response. Bioaerosols/organic dusts are important agricultural pollutants that may lead to COPD. These environments are complex containing a rich source of various microbial components. The objective of this study was to determine whether individuals with COPD have enhanced systemic responsiveness to settled swine facility organic dust extract (ODE) or its main pathogenic components (peptidoglycan [PGN], lipopolysaccharide [LPS]) versus healthy volunteers. A modified whole blood assay (WBA) that included occupational levels of ODE and concentrations of LPS and PGN found in ODE was used to determine systemic responsiveness (mediator release), and sputum inflammatory markers were measured to explore for systemic and airway associations. Sputum samples were evaluated for cell counts, and TNF-α, IL-8/CXCL8, IL-6, and IL-10. Ex vivo whole blood stimulation with ODE, LPS, and PGN each resulted in significant mediator release in all subjects, the highest occurring with ODE; PGN resulted in significantly enhanced TNF-α and IL-8 as compared to LPS. COPD subjects demonstrated greater systemic responsiveness using the modified WBA versus healthy controls. Within COPD subjects, blood baseline TNF-α, IL-8, and IL-10 and ODE, PGN, and LPS-stimulated IL-8 levels significantly correlated with lung function. In conclusion, dust-induced mediator release was robust, and PGN, in part, resembled dust-induced mediator release. Subjects with COPD demonstrated increased mediator release following ex vivo whole blood stimulation with bioaerosol components suggesting that circulating blood cells in COPD subjects may be primed to respond greater to microbial/inflammatory insult

Probing the atmosphere of HD189733b with the Na I and K I lines

High spectral resolution transmission spectroscopy is a powerful tool to characterize exoplanet atmospheres. Especially for hot Jupiters, this technique is highly relevant, due to their high altitude absorption e.g. from resonant sodium (Na I) and potassium (K I) lines. We resolve the atmospheric K I-absorption on HD189733b with the aim to compare the resolved K I -line and previously obtained high resolution Na I-D-line observations with synthetic transmission spectra. The line profiles suggest atmospheric processes leading to a line broadening of the order of 10 km/s for the Na I-D-lines, and only a few km/s for the K I-line. The investigation hints that either the atmosphere of HD189733b lacks a significant amount of K I or the alkali lines probe different atmospheric regions with different temperature, which could explain the differences we see in the resolved absorption lines