Breaking waves on a dynamic Hele-Shaw beach

We report the formation of quasi-steady beaches and dunes via breaking waves in our tabletop ‘Hele-Shaw’ beach experiment. Breaking waves are generated by a wave maker, and zeolite particles act as sand. The tank is narrow, just over one-particle diameter wide, creating a quasi-2D set-up. Classical breaker types are observed on a time-scale of about a second. Beach formation under breakers occurs on a longer time-scale, and is a matter of minutes for a range of mono-chromatic wave frequencies. Alternating the wave maker motion between two frequencies generally leads to beach formation but occasionally to formation of a stable dune with water on either side. Finally, the Hele-Shaw configuration explored here experimentally lends itself to multi-scale modeling of beach dynamics

Revisiting Hele-Shaw dynamics to better understand beach evolution

Wave action, particularly during storms, drives the evo lution of beaches. Beach evolution by non-linear break ing waves is poorly understood due to its three-dimensional character, the range of scales involved, and our limited understanding of particle-wave interactions. We show how a novel, three-phase extension to the classic “Hele-Shaw” laboratory experiment can be designed that creates beach morphologies with breaking waves in a quasi-two-dimensional setting. Our thin Hele-Shaw cell simplifies the inherent complexity of three-phase dynamics: all dynamics become clearly visible and measurable. We show that beaches can be created in tens of minutes by several types of breaking waves, with about one-second periods. Quasi-steady beach morphologies emerge as function of initial water depth, at-rest bed level and wave-maker frequency. These are classified mathematically and lead to beaches, berms and sand bars

Fast Ejection Chain Algorithms for Vehicle Routing with Time Windows

This paper introduces new ejection chain strategies to effectively target vehicle routing problems with time window constraints (VRPTW). Ejection chain procedures are based on the idea of compound moves that allow a variable number of solution components to be modified within any single iteration of a local search algorithm. The yardstick behind such procedures is the underlying reference structure, which is the structure that is used to coordinate the moves that are available for the local search algorithm. The main contribution of the paper is a new reference structure that is particularly suited in order to handle the asymmetric aspects in a VRPTW. The new reference structure is a generalization of the doubly rooted reference structure introduced by Glover, resulting in a new, powerful neighborhood for the VRPTW. We use tabu search for the generation of the ejection chains. On a higher algorithmic level, we study the effect of different meta heuristics to steer the tabu chain ejection process. Computational results confirm that our approach leads to very fast algorithms that can compete with the current state of the art algorithms for the VRPTW.operations research and management science;

Canonical matrices of bilinear and sesquilinear forms

Canonical matrices are given for (a) bilinear forms over an algebraically closed or real closed field; (b) sesquilinear forms over an algebraically closed field and over real quaternions with any nonidentity involution; and (c) sesquilinear forms over a field F of characteristic different from 2 with involution (possibly, the identity) up to classification of Hermitian forms over finite extensions of F. A method for reducing the problem of classifying systems of forms and linear mappings to the problem of classifying systems of linear mappings is used to construct the canonical matrices. This method has its origins in representation theory and was devised in [V.V. Sergeichuk, Math. USSR-Izv. 31 (1988) 481-501].Comment: 44 pages; misprints corrected; accepted for publication in Linear Algebra and its Applications (2007

Hele-Shaw beach creation by breaking waves

Fundamentals of nonlinear wave-particle interactions are studied in a Hele-Shaw conguration with wave breaking and a dynamic bed. To design this configuration, we determine, mathematically, the gap width which allows inertial flows to survive the viscous damping due to the side walls. Damped wave sloshing experiments compared with simulations confirm that width-averaged potential-flow models with linear momentum damping are adequately capturing the large scale nonlinear wave motion. Subsequently, we show that the four types of wave breaking on real-world beaches also emerge on Hele-Shaw laboratory beaches, albeit in idealized forms. Finally, an experimental parameter study is undertaken to quantify the formation of quasi-steady beach morphologies due to nonlinear, breaking waves: berm or dune, beach and sandbar formation are all classied. Our research reveals that the Hele-Shaw beach conguration allows a wealth of experimental and modelling extensions, including benchmarking of forecast models used in the coastal engineering practice

Drugs with anti-inflammatory effects to improve outcome of traumatic brain injury:a meta-analysis

Outcome after traumatic brain injury (TBI) varies largely and degree of immune activation is an important determinant factor. This meta-analysis evaluates the efficacy of drugs with anti-inflammatory properties in improving neurological and functional outcome. The systematic search following PRISMA guidelines resulted in 15 randomized placebo-controlled trials (3734 patients), evaluating progesterone, erythropoietin and cyclosporine. The meta-analysis (15 studies) showed that TBI patients receiving a drug with anti-inflammatory effects had a higher chance of a favorable outcome compared to those receiving placebo (RR = 1.15; 95% CI 1.01-1.32, p = 0.041). However, publication bias was indicated together with heterogeneity (I-2 = 76.59%). Stratified analysis showed that positive effects were mainly observed in patients receiving this treatment within 8 h after injury. Subanalyses by drug type showed efficacy for progesterone (8 studies, RR 1.22; 95% CI 1.01-1.47, p = 0.040), again heterogeneity was high (I-2 = 62.92%) and publication bias could not be ruled out. The positive effect of progesterone covaried with younger age and was mainly observed when administered intramuscularly and not intravenously. Erythropoietin (4 studies, RR 1.20; p = 0.110; I-2 = 76.59%) and cyclosporine (3 studies, RR 0.75; p = 0.189, I-2 = 0%) did not show favorable significant effects. While negative findings for erythropoietin may reflect insufficient power, cyclosporine did not show better outcome at all. Current results do not allow firm conclusions on the efficacy of drugs with anti-inflammatory properties in TBI patients. Included trials showed heterogeneity in methodological and sample parameters. At present, only progesterone showed positive results and early administration via intramuscular administration may be most effective, especially in young people. The anti-inflammatory component of progesterone is relatively weak and other mechanisms than mitigating overall immune response may be more important

Disentangling the effects of age and mild traumatic brain injury on brain network connectivity:A resting state fMRI study

INTRODUCTION: Cognitive complaints are common shortly after mild traumatic brain injury (mTBI) but may persist up to years. Age-related cognitive decline can worsen these symptoms. However, effects of age on mTBI sequelae have scarcely been investigated. METHODS: Fifty-four mTBI patients (median age: 35 years, range 19-64 years, 67% male) and twenty age- and sex-matched healthy controls were studied using resting state functional magnetic resonance imaging in the sub-acute phase. Independent component analysis was used to identify intrinsic connectivity networks (ICNs). A multivariate approach was adopted to evaluate the effects of age and group on the ICNs in terms of (static) functional network connectivity (FNC), intensities of spatial maps (SMs) and time-course spectral power (TC). RESULTS: We observed significant age-related changes for a) FNC: changes between 10 pairs of ICNs, mostly involving the default mode (DM) and/or the cognitive-control (CC) domains; b) SMs: intensity decrease in clusters across three domains and intensity increase in clusters across two domains, including the CC but not the DM and c) TC: spectral power decrease within the 0-0.15 Hz range and increase within the 0.20-0.25 Hz range for increasing age within networks located in frontal areas, including the anterior DM. Groups only differed for TC within the 0.065-0.10 Hz range in the cerebellar ICN and no age × group interaction effect was found. CONCLUSIONS: We showed robust effects of age on connectivity between and within ICNs that are associated with cognitive functioning. Differences between mTBI patients and controls were only found for activity in the cerebellar network, increasingly recognized to participate in cognition. Our results suggest that to allow for capturing the true effects related to mTBI and its effects on cognitive functioning, age should be included as a covariate in mTBI studies, in addition to age-matching groups