The spatial and age distribution of stellar populations in DDO 190

The spatial distribution of stellar populations, the star formation history, and other properties of the dIrr galaxy DDO 190 have been analyzed using color--magnitude diagrams (CMDs) of about 3900 resolved stars and the Ha fluxes of HII regions. From the mean color index of the red giant branch, a mean metallicity [Fe/H]=-2.0 is obtained. The I magnitude of the TRGB has been used to estimate the distance. DDO 190 is 2.9+/-0.2 Mpc from the Milky Way, 2.1 Mpc from the M 94 group (CnV-I), 2.4 Mpc from the M 81 group and 2.9 Mpc from the barycenter of the Local Group, all indicating that it is an isolated, field galaxy. The surface-brightness distribution of the galaxy is well fitted by ellipses of ellipticity e=1-a/b=0.1 and P.A.=82deg. The radial star density distribution follows an exponential law of scale length a=43."4, corresponding to 611 pc. The Holmberg semi-major axis to mu_B=26.5 is estimated to be r^B_(26.5)=3.'0. Stellar populations of different ages in DDO 190 show strong spatial decoupling, the oldest population appearing much more extended than the youngest. Stars younger than 0.1 Gyr occupy only the central 40'' (0.55 kpc); stars younger than a few (~4) Gyr extend out to ~80'' (125 kpc), and for larger galactocentric distances only older stars seem to be present. This behavior is found in all the dIrr galaxies for which spatially extended studies have been performed and could be related with the kinematical history of the galaxy.Comment: To be published in the AJ. 29 pages, 13 figure

Shape Isomerism at N = 40: Discovery of a Proton Intruder in 67Co

The nuclear structure of 67Co has been investigated through 67Fe beta-decay. The 67Fe isotopes were produced at the LISOL facility in proton-induced fission of 238U and selected using resonant laser ionization combined with mass separation. The application of a new correlation technique unambiguously revealed a 496(33) ms isomeric state in 67Co at an unexpected low energy of 492 keV. A 67Co level scheme has been deduced. Proposed spin and parities suggest a spherical (7/2-) 67Co ground state and a deformed first excited (1/2-) state at 492 keV, interpreted as a proton 1p-2h prolate intruder state.Comment: 4 pages, 5 figures, preprint submitted to Physical Review Letter

Дослідження підходів до оцінки стану конкурентоспроможності підприємств

Мета статті – наведення підходів до оцінки стану конкурентоспроможності підприємств

On the frequency and remnants of Hypernovae

Under the hypothesis that some fraction of massive stellar core collapses give rise to unusually energetic events, termed hypernovae, I examine the required rates assuming some fraction of such events yield gamma ray bursts. I then discuss evidence from studies of pulsars and r-process nucleosynthesis that independently suggests the existence of a class of unusually energetic events. Finally I describe a scenario which links these different lines of evidence as supporting the hypernova hypothesis.Comment: TeX, To appear in ApJ Letter

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition

The angiogenesis inhibitor sunitinib is a tyrosine kinase inhibitor that acts mainly on the VEGF and PDGF pathways. We have previously shown that sunitinib is sequestered in the lysosomes of exposed tumor and endothelial cells. This phenomenon is part of the drug-induced resistance observed in the clinic. Here, we demonstrate that when exposed to light, sequestered sunitinib causes immediate destruction of the lysosomes, resulting in the release of sunitinib and cell death. We hypothesized that this photoactivation of sunitinib could be used as a vaso-occlusive vascular-targeting approach to treating cancer. Spectral properties of sunitinib and its lysosomal accumulation were measured in vitro. The human A2780 ovarian carcinoma transplanted onto the chicken chorioallantoic membrane (CAM) and the Colo-26 colorectal carcinoma model in Balb/c mice were used to test the effects of administrating sunitinib and subsequently exposing tumor tissue to light. Tumors were subsequently resected and subject to immunohistochemical analysis. In A2780 ovarian carcinoma tumors, treatment with sunitinib+light resulted in immediate specific angio-occlusion, leading to a necrotic tumor mass 24 h after treatment. Tumor growth was inhibited by 70% as compared with the control group (**P= 4; P = 0.0002). Histology revealed that photoactivation of sunitinib resulted in a change in tumor vessel architecture. The current results suggest that the spectral properties of sunitinib can be exploited for application against certain cancer indications

The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena

Background: In 2018, a grant was provided for an evidence-based guideline on osteoporosis and fracture prevention based on 10 clinically relevant questions. Methods: A multidisciplinary working group was formed with delegates from Dutch scientific and professional societies, including representatives from the patient’s organization and the Dutch Institute for Medical Knowledge. The purpose was to obtain a broad consensus among all participating societies to facilitate the implementation of the updated guideline. Results: Novel recommendations in our guideline are as follows: - In patients with an indication for DXA of the lumbar spine and hips, there is also an indication for VFA. - Directly starting with anabolic drugs (teriparatide or romosozumab) in patients with a very high fracture risk; - Directly starting with zoledronic acid in patients 75 years and over with a hip fracture (independent of DXA); - Directly starting with parenteral drugs (denosumab, teriparatide, zoledronic acid) in glucocorticoid-induced osteoporosis with very high fracture risk; - A lifelong fracture risk management, including lifestyle, is indicated from the start of the first treatment. Conclusion: In our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implementation.</p

The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena

Background: In 2018, a grant was provided for an evidence-based guideline on osteoporosis and fracture prevention based on 10 clinically relevant questions. Methods: A multidisciplinary working group was formed with delegates from Dutch scientific and professional societies, including representatives from the patient’s organization and the Dutch Institute for Medical Knowledge. The purpose was to obtain a broad consensus among all participating societies to facilitate the implementation of the updated guideline. Results: Novel recommendations in our guideline are as follows: - In patients with an indication for DXA of the lumbar spine and hips, there is also an indication for VFA. - Directly starting with anabolic drugs (teriparatide or romosozumab) in patients with a very high fracture risk; - Directly starting with zoledronic acid in patients 75 years and over with a hip fracture (independent of DXA); - Directly starting with parenteral drugs (denosumab, teriparatide, zoledronic acid) in glucocorticoid-induced osteoporosis with very high fracture risk; - A lifelong fracture risk management, including lifestyle, is indicated from the start of the first treatment. Conclusion: In our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 “relatively new statements” that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implementation.</p

Frame dragging, vorticity and electromagnetic fields in axially symmetric stationary spacetimes

We present a general study about the relation between the vorticity tensor and the Poynting vector of the electromagnetic field for axially symmetric stationary electrovacuum metrics. The obtained expressions allow to understand the role of the Poynting vector in the dragging of inertial frames. The particular case of the rotating massive charged magnetic dipole is analyzed in detail. In addition, the electric and magnetic parts of the Weyl tensor are calculated and the link between the later and the vorticity is established. Then we show that, in the vacuum case, the necessary and sufficient condition for the vanishing of the magnetic part is that the spacetime be static.Comment: 16 pages Latex. Some minor changes in the text and typos correcte