Students\u27 role in the development of an optional subjects-line in a medical curriculum

Context: In 1999, the medical curriculum of Ghent University underwent a fundamental change. The new curriculum is problem-based, emphasizing both horizontal and vertical integration. One of its remarkable qualities is the possibility of continuous evolution through permanent reflection and evaluation. The students, organised in the Student\u27s Association on Education, take an active part in this process. Recently, students remarked that the offer of optional subjects in the new curriculum was limited. Apart from the thesis, there was no formal opportunity to gain more in-depth knowledge on an individually chosen subject. Objective: To explore the possibilities of optional subjects in a medical curriculum. Design: Using a survey, fifth year students were questioned on the need for optional subjects. The results of this, as well as the inspiration we gained during a visit at the faculty of medicine of Maastricht University served as a starting point for a round-table meeting with members of the educational board. Interventions: As it is difficult to decide to what extent subjects can be optional, this matter was introduced gradually. Initially, one week in the fifth year of the curriculum was reserved for options. Students were also offered the possibility to suggest own subjects. Results: The first time this week was organised, thirteen optional subjects, proposed by lecturers, were offered. Additionally, one subject was suggested by a group of students: they set up a community-oriented educational programme in a secondary school in Ghent. The evaluation of both initiatives was organized by the students. The results were encouraging. Conclusions: The project we present is still in its infancy, but we work on the development of a complete \u27Exploration-continuum\u27. In this way, students should be able to deepen their knowledge in particular fields and attribute a personal tinge to their education. This might enhance the motivation and involvement towards their studies and future profession

Geometric and Radiometric Correction of Multibeam Backscatter Derived from Reson 8101 Systems

A common by-product of multibeam surveys is a measure of the backscattered acoustic intensity from the seafloor. These data are of immense interest to geologists and geoscientists since maps of the acoustic backscatter strength can be used to infer physical properties of the sea bottom, such as impedance, roughness and volume inhomogeneity. Before such maps can be created from multibeam acoustic backscatter data, however, two tasks must be performed. 1. The data must be geographically registered using the bathymetric profile collected by the multibeam (which accounts for full orientation and refraction), as opposed to using the traditional flat-seafloor assumption. This allows us to additionally calculate the true grazing angle. 2. The signal intensities must be reduced to as close a measure of the backscatter strength of the seafloor as possible by radiometrically correcting the data on a ping-by-ping basis for variables such as transmission power, beam pattern, receiver gain, and pulse length. The purpose of this research project is to develop software tools to perform the above corrections for a massive backlog of RESON SeaBat 8101 multibeam data, as collected by the NOAA ship Rainier. While the backscatter logged by the multibeam systems is not of prime importance to NOAA’s hydrographic charting mandate, they recognize the potential value of this data to the work of other sister agencies such as the U.S. Geological Survey (who is funding this project). The particular problems encountered with these data are that. Up to the end of 2001 field season, the backscatter data acquired by this system were collected from dedicated receiver beams, separate from those used for bathymetry. This receive beam is broad in the elevation plane (similar to a sidescan sonar) so that the variation in elevation angle with time must be indirectly inferred from the corresponding bathymetric profile. As some backscatter data are collected from slant-ranges beyond which bathymetric data are acquired, for that case the imaging geometry must be either inferred using a simple slope model, or derived from neighbouring swaths. Results of the application of full geometric and radiometric corrections will be presented

The role of the healthcare sector in the prevention of sexual violence against sub-Saharan transmigrants in Morocco : a study of knowledge, attitudes and practices of healthcare workers

Background: Sub-Saharan transmigrants in Morocco are extremely vulnerable to sexual violence. From a public health perspective, the healthcare system is globally considered an important partner in the prevention of sexual violence. The aim of this study is twofold. In a first phase, we aimed to identify the current role and position of the Moroccan healthcare sector in the prevention of sexual violence against sub-Saharan transmigrants. In a second phase, we wanted these results and available guidelines to be the topic of a participatory process with local stakeholders in order to formulate recommendations for a more desirable prevention of sexual violence against sub-Saharan transmigrants by the Moroccan healthcare sector. Methods: Knowledge, attitudes and practices of healthcare workers in Morocco concerning sexual violence against sub-Saharan transmigrants and its prevention were firstly explored in semi-structured interviews after which they were discussed in a participatory process resulting in the formulation of recommendations. Results: All participants (n=24) acknowledged the need for desirable prevention of sexual violence against transmigrants. Furthermore, important barriers in tertiary prevention practices, i.e. psychosocial and judicial referral and long-term follow-up, and in secondary prevention attitudes, i.e. active identification of victims were identified. Moreover, existing services for Moroccan victims of sexual violence currently do not address the sub-Saharan population. Thus, transmigrants are bound to rely on the aid of civil society. Conclusions: This research demonstrates the low accessibility of existing Moroccan services for sub-Saharan migrants. In particular, there is an absence of prevention initiatives addressing sexual violence against the sub-Saharan transmigrant population. Although healthcare workers do wish to develop prevention initiatives, they are dealing with structural difficulties and a lack of expertise. Recommendations adapted to the context of sub-Saharan transmigrants in Morocco are suggested

POST-TRAUMATIC STRESS DISORDER AFTER COVID-19 INTENSIVE CARE ADMISSION: CHARACTERISTICS AND PERSPECTIVES

An increase of psychopathology such as post-traumatic stress disorder (PTSD) is described in patients affected with COVID- 19 that stayed at an intensive care unit (ICU). However, data on follow-up and on impact of contextual factors are limited. In a single-center, observational study, PTSD symptomatology was prevalent among 38% of participants (n=8), persisting in clinical PTSD in 2 participants after one year. In patients with initial PTSD symptoms, scores on depression, anxiety and insomnia sca les were significantly higher. A higher mental burden due to avoidance of contact and a reduced quality of life was also retained in patients with PTSD symptoms

Chronic pain is common in mitochondrial disease

In the absence of cure, the main objectives in the management of patients with mitochondrial disease are symptom control and prevention of complications. While pain is a complicating symptom in many chronic diseases and is known to have a clear impact on quality of life, its prevalence and severity in people with genetically confirmed mitochondrial disease is unknown. We conducted a survey of pain symptoms in patients with genetically confirmed mitochondrial disease from two UK mitochondrial disease specialist centres. The majority (66.7%) of patients had chronic pain which was primarily of neuropathic nature. Presence of pain did not significantly impact overall quality of life. The m.3243A>G MTTL1 mutation was associated with higher overall pain severity and increased the likelihood of neuropathic pain compared to other causative nuclear and mitochondrial gene mutations. Although previously not considered a core symptom in people with mitochondrial disease, pain is a common clinical manifestation, frequently of neuropathic nature, and influenced by genotype. Given the impact on quality of life and treatment options available, pain-related symptoms should be carefully characterised and actively managed in this patient population

In vivo targeted DamID identifies CHD8 genomic targets in fetal mouse brain.

Funder: Royal SocietyFunder: Agouron InstituteGenetic studies of autism have revealed causal roles for chromatin remodeling gene mutations. Chromodomain helicase DNA binding protein 8 (CHD8) encodes a chromatin remodeler with significant de novo mutation rates in sporadic autism. However, relationships between CHD8 genomic function and autism-relevant biology remain poorly elucidated. Published studies utilizing ChIP-seq to map CHD8 protein-DNA interactions have high variability, consistent with technical challenges and limitations associated with this method. Thus, complementary approaches are needed to establish CHD8 genomic targets and regulatory functions in developing brain. We used in utero CHD8 Targeted DamID followed by sequencing (TaDa-seq) to characterize CHD8 binding in embryonic mouse cortex. CHD8 TaDa-seq reproduced interaction patterns observed from ChIP-seq and further highlighted CHD8 distal interactions associated with neuronal loci. This study establishes TaDa-seq as a useful alternative for mapping protein-DNA interactions in vivo and provides insights into the regulatory targets of CHD8 and autism-relevant pathophysiology associated with CHD8 mutations

Targeted DamID reveals differential binding of mammalian pluripotency factors.

The precise control of gene expression by transcription factor networks is crucial to organismal development. The predominant approach for mapping transcription factor-chromatin interactions has been chromatin immunoprecipitation (ChIP). However, ChIP requires a large number of homogeneous cells and antisera with high specificity. A second approach, DamID, has the drawback that high levels of Dam methylase are toxic. Here, we modify our targeted DamID approach (TaDa) to enable cell type-specific expression in mammalian systems, generating an inducible system (mammalian TaDa or MaTaDa) to identify genome-wide protein/DNA interactions in 100 to 1000 times fewer cells than ChIP-based approaches. We mapped the binding sites of two key pluripotency factors, OCT4 and PRDM14, in mouse embryonic stem cells, epiblast-like cells and primordial germ cell-like cells (PGCLCs). PGCLCs are an important system for elucidating primordial germ cell development in mice. We monitored PRDM14 binding during the specification of PGCLCs, identifying direct targets of PRDM14 that are key to understanding its crucial role in PGCLC development. We show that MaTaDa is a sensitive and accurate method for assessing cell type-specific transcription factor binding in limited numbers of cells

Prediction of electroconvulsive therapy response and remission in major depression: Meta-analysis

Electroconvulsive therapy (ECT) is considered to be the most effective treatment in severe major depression. The identification of reliable predictors of ECT response could contribute to a more targeted patient selection and consequently increased ECT response rates. Aims To investigate the predictive value of age, depression severity, psychotic and melancholic features for ECT response and remission in major depression. Method A meta-analysis was conducted according to the PRISMA statement. A literature search identified recent studies that reported on at least one of the potential predictors. Results Of the 2193 articles screened, 34 have been included for metaanalysis. Presence of psychotic features is a predictor of ECT remission (odds ratio (OR) = 1.47, P = 0.001) and response (OR = 1.69, P < 0.001), as is older age (standardised mean difference (SMD) = 0.26 for remission and 0.35 for response (P < 0.001)). The severity of depression predicts response (SMD = 0.19, P = 0.001), but not remission. Data on melancholic symptoms were inconclusive. Conclusions ECT is particularly effective in patients with depression with psychotic features and in elderly people with depression. More research on both biological and clinical predictors is needed to further evaluate the position of ECT in treatment protocols for major depression

SERVER VIRTUALIZATION USE PHPVIRTUALBOX

ABSTRACT Make the server as an important learning so that we know how to create a server in a computer network laboratory in the Faculty of Computer Science Soegijapranata Catholic University. Experimenting server has a big risk to the computer laboratory, therefore server virtualization is a solution that can minimize the risk of damage. Creating server virtualization using phpVirtualBox as a service for clients. The first process the server must connect to the network and have VirtualBox, phpVirtualBox as a service. The server has a phpVirtualBox service that can be accessed by a client via browser with IP address server. Keyword: Server, Client, VirtualBox, phpVirtualBox, Operating Syste