Towards a responsible agenda for academic literacy development: considerations that will benefit students and society

The transition from secondary to higher education (HE) requires a change of cultural mindset (cf. Darlaston-Jones et al., 2003; Leki, 2006). It is widely accepted that the academic performance and motivation of first year students to stay in HE depend, among others, on how well they integrate into the university environment (Brinkworth et al., 2009). Academic integration or acculturation takes different forms. The premise of this article is that students have to learn to engage with academic discourse, i.e., they must acquire the community’s communicative currency, defined as different kinds of language used to reflect the community’s current norms, practices, values and expectations (cf., among others, Duff, 2010; Gee, 1998, 2000; Hyland, 2009). As reflective and responsible practitioners we therefore need to outline a critical agenda for academic acculturation by reviewing the debate on the nature of literacy and,  particularly, by discussing similarities and differences in epistemology and approaches to literacy. Such an agenda will have to recognise insights gained from, in particular, the New Literacy Studies (Street, 1998, 2004) and the Academic Literacies movement (Lea & Street, 1998; Lillis & Scott, 2007), but it will also become enriched by a linguistic perspective (Biber, 2006; Blanton, 1994; Bachman & Palmer, 1996; Halliday, 1978, 1985, 1993, 1996, 2002; Hyland, 2009). In developing a template for the agenda we accordingly acknowledge the theoretical defensibility and the feasibility of different approaches to academic acculturation.Keywords: academic literacy development, academic discourse, academic  acculturation or integration, higher educatio

Reading Ability and Academic Acculturation: The Case of South African Students entering Higher Education

First-year students experience a range of challenges when transferring from secondary to higher education (HE) (cf. Darlaston-Jones et al. 2003, Leki 2006, Brinkworth et al. 2009). This is no different in South Africa, where deviating levels of preparedness for the demands of HE is a recurring theme (Slonimsky and Shalem 2005, Van Schalkwyk 2008, Scott 2009, Yeld 2009, Van Dyk 2010, Van Dyk and Coetzee-Van Rooy 2012). Weideman (2003:56) rightfully points out that the inability to understand and utilise appropriate academic discourse has a detrimental effect on academic success. Young students need to acculturate to the academic environment while adopting the academic community’s currency (Van de Poel and Gasiorek 2012a:294). With this article, we wish to contribute to the discussion by reporting on the academic language ability of one group of first-year students at a South African university, with specific reference to these students’ reading ability, on the basis of the following data: (i) individual differences in terms of learner characteristics (race, first language, gender, Grade 12 results, academic performance); (ii) self-reported reading preparedness; and (iii) reading profiles resulting from a valid and reliable academic literacy test, the Test of Academic Literacy Levels (TALL) and its Afrikaans counterpart, the Toets van Akademiese Geletterdheidsvlakke (TAG). The findings suggest that academic reading ability, as reflected in the test results, is indeed one of the salient contributors to academic success (as confirmed in the literature), regardless of social and individual differences, and that it needs to be supported in order for students to perceive their reading ability in accordance with their reading performance and be able to progress in their academic acculturation. A follow-up study will report on students’ awareness-raising about their own academic reading through the use of the validated scale for Perceived Academic Reading Preparedness (PARP) as a pedagogical tool.Keywords: Academic Acculturation, Academic Literacy, Academic Reading, Perceptions of Reading Ability, Academic Performanc

PSMA, EpCAM, VEGF and GRPR as Imaging Targets in Locally Recurrent Prostate Cancer after Radiotherapy

In this retrospective pilot study, the expression of the prostate-specific membrane antigen (PSMA), the epithelial cell adhesion molecule (EpCAM), the vascular endothelial growth factor (VEGF) and the gastrin-releasing peptide receptor (GRPR) in locally recurrent prostate cancer after brachytherapy or external beam radiotherapy (EBRT) was investigated, and their adequacy for targeted imaging was analyzed. Prostate cancer specimens were collected of 17 patients who underwent salvage prostatectomy because of locally recurrent prostate cancer after brachytherapy or EBRT. Immunohistochemistry was performed. A pathologist scored the immunoreactivity in prostate cancer and stroma. Staining for PSMA was seen in 100% (17/17), EpCAM in 82.3% (14/17), VEGF in 82.3% (14/17) and GRPR in 100% (17/17) of prostate cancer specimens. Staining for PSMA, EpCAM and VEGF was seen in 0% (0/17) and for GRPR in 100% (17/17) of the specimens’ stromal compartments. In 11.8% (2/17) of cases, the GRPR staining intensity of prostate cancer was higher than stroma, while in 88.2% (15/17), the staining was equal. Based on the absence of stromal staining, PSMA, EpCAM and VEGF show high tumor distinctiveness. Therefore, PSMA, EpCAM and VEGF can be used as targets for the bioimaging of recurrent prostate cancer after EBRT to exclude metastatic disease and/or to plan local salvage therapy

Visions, Values, and Videos: Revisiting Envisionings in Service of UbiComp Design for the Home

UbiComp has been envisioned to bring about a future dominated by calm computing technologies making our everyday lives ever more convenient. Yet the same vision has also attracted criticism for encouraging a solitary and passive lifestyle. The aim of this paper is to explore and elaborate these tensions further by examining the human values surrounding future domestic UbiComp solutions. Drawing on envisioning and contravisioning, we probe members of the public (N=28) through the presentation and focus group discussion of two contrasting animated video scenarios, where one is inspired by "calm" and the other by "engaging" visions of future UbiComp technology. By analysing the reasoning of our participants, we identify and elaborate a number of relevant values involved in balancing the two perspectives. In conclusion, we articulate practically applicable takeaways in the form of a set of key design questions and challenges.Comment: DIS'20, July 6-10, 2020, Eindhoven, Netherland

VITAL, Monitoring and Control for Virus Safe Pork

VITAL is an ongoing (2008-2011) EU funded project on monitoring and control of food-borne viruses. The concept of VITAL is the integrated risk assessment and management of contamination of the European farm to market food chain by pathogenic viruses, such as norovirus and hepatitis E virus. The project’s focus is on the production and processing phase, moving away from the concept of endpoint monitoring towards input monitoring

Specialist versus primary care prostate cancer follow-up:A process evaluation of a randomized controlled trial

Background: A randomized controlled trial (RCT) is currently comparing the effectiveness of specialist- versus primary care-based prostate cancer follow-up. This process evaluation assesses the reach and identified constructs for the implementation of primary care-based follow-up. Methods: A mixed-methods approach is used to assess the reach and the implementation through the Consolidated Framework for Implementation Research. We use quantitative data to evaluate the reach of the RCT and qualitative data (interviews) to indicate the perspectives of patients (n = 15), general practitioners (GPs) (n = 10), and specialists (n = 8). Thematic analysis is used to analyze the interview transcripts. Results: In total, we reached 402 (67%) patients from 12 hospitals and randomized them to specialist- (n = 201) or to primary care-based (n = 201) follow-up. From the interviews, we identify several advantages of primary care- versus specialist-based follow-up: it is closer to home, more accessible, and the relationship is more personal. Nevertheless, participants also identified challenges: guidelines should be implemented, communication and collaboration between primary and secondary care should be improved, quality indicators should be collected, and GPs should be compensated. Conclusion: Within an RCT context, 402 (67%) patients and their GPs were willing to receive/provide primary care-based follow-up. If the RCT shows that primary care is equally as effective as specialist-based follow-up, the challenges identified in this study need to be addressed to enable a smooth transition of prostate cancer follow-up to primary care. Netherlands Trial Registry, Trial NL7068 (NTR7266)

Use of technology that supports daily structure for people with acquired brain injury or mild intellectual disability:A literature review

InleidingMensen met niet-aangeboren hersenletsel (NAH) en een licht verstandelijke beperking (LVB) hebben vaak moeite met dagstructuur. Technologie kan hierbij als ondersteuning worden ingezet. Vanuit de praktijk ontstond de vraag wat in de wetenschappelijke literatuur bekend is over de inzet van technologie ter ondersteuning van dagstructuur bij mensen met NAH en LVB. In deze studie doen we literatuuronderzoek om antwoord te geven op deze vraag.MethodeWe deden twee zoekacties binnen de wetenschappelijke literatuur, één voor de doelgroep NAH en vervolgens een geüpdatete zoekactie voor de doelgroep NAH en LVB.ResultatenUit de eerste zoekactie includeerden we 12 artikelen gepubliceerd vanaf 2010 en uit de tweede zoekactie vier reviews die focusten op de doelgroep NAH. We vonden slechts één review die de doelgroep LVB includeerde.ConclusieUit de gevonden studies blijkt dat de inzet van technologie een positief effect heeft op het behalen van doelen en psychosociale uitkomsten. Vooral draagbare technologie zoals (apps op) smartphones kunnen via prompts en timecues bijdragen aan een betere dagstructuur van mensen met NAH of een LVB. Voor succesvol gebruik op de lange termijn zijn aandacht voor een match in de keuze van technologie en voor training in het gebruik van de technologie noodzakelijk. Over meer recent opkomende technologieën als zorgrobots en smartwatches is nog weinig te vinden

Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids

Background: Pharmacotherapies for people with cystic fibrosis (pwCF) who have premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are under development. Thus far, clinical studies focused on compounds that induce translational readthrough (RT) at the mRNA PTC location. Recent studies using primary airway cells showed that PTC functional restoration can be achieved through combining compounds with multiple mode-of-actions. Here, we assessed induction of CFTR function in PTC-containing intestinal organoids using compounds targeting RT, nonsense mRNA mediated decay (NMD) and CFTR protein modulation. Methods: Rescue of PTC CFTR protein was assessed by forskolin-induced swelling of 12 intestinal organoid cultures carrying distinct PTC mutations. Effects of compounds on mRNA CFTR level was assessed by RT-qPCRs. Results: Whilst response varied between donors, significant rescue of CFTR function was achieved for most donors with the quintuple combination of a commercially available pharmacological equivalent of the RT compound (ELX-02-disulfate or ELX-02ds), NMD inhibitor SMG1i, correctors VX-445 and VX-661 and potentiator VX-770. The quintuple combination of pharmacotherapies reached swelling quantities higher than the mean swelling of three VX-809/VX-770-rescued F508del/F508del organoid cultures, indicating level of rescue is of clinical relevance as VX-770/VX-809-mediated F508del/F508del rescue in organoids correlate with substantial improvement of clinical outcome. Conclusions: Whilst variation in efficacy was observed between genotypes as well as within genotypes, the data suggests that strong pharmacological rescue of PTC requires a combination of drugs that target RT, NMD and protein function