The 2011 Workplace Employment Relations Study: first findings

The 2011 Workplace Employment Relations Study (WERS) is the sixth survey of employment relations in Britain. It collected data from a representative sample of 2,680 British workplaces, from: 2,680 workplace managers responsible for employment relations and personnel 1,002 worker representatives 21,981 employee

Who Fared Better? The Fortunes of Performance Pay and Fixed Pay Workers through Recession

Using the Annual Survey of Hours and Earnings, we explore whether the fortunes of employees paid for performance differ from those of fixed pay workers during recession. Only in the bottom quintile of the wage distribution were performance pay employees more likely to experience greater falls in real wages than fixed pay employees. Accounting for fixed unobserved worker characteristics suggests that this was not due to the wage‐setting mechanism itself, but that other factors are likely to be at play. While across most of the earnings distribution there was little evidence of greater wage flexibility among performance pay employees, they did have longer job tenure than fixed pay employees over the recession

Cabin crew collectivism: labour process and the roots of mobilization

The protracted dispute (2009–11) between British Airways and BASSA (British Airways Stewards and Stewardesses Association) was notable for the strength of collective action by cabin crew. In-depth interviews reveal collectivism rooted in the labour process and highlight the key agency of BASSA in effectively articulating worker interests. This data emphasizes crews’ relative autonomy, sustained by unionate on-board Cabin Service Directors who have defended the frontier of control against managerial incursions. Periodic attempts to re-configure the labour process, driven by cost cutting imperatives in an increasingly competitive airline industry, eroded crews’ organizational loyalties. When BA imposed radical changes to contracts and working arrangements, BASSA successfully mobilized its membership. The article contributes to labour process analysis by emphasizing the collective dimensions to emotional labour, restoring the ‘missing subject’, but also articulating the interconnections between labour process and mobilization and the role unions can play in providing the organizational and ideological resources to legitimate worker interest

Limited-sampling strategies for anidulafungin in critically ill patients

Efficacy of anidulafungin is driven by the area under the concentration-time curve (AUC)/MIC ratio. Determination of the anidulafungin AUC along with MIC values can therefore be useful. Since obtaining a full concentration-time curve to determine an AUC is not always feasible or appropriate, limited-sampling strategies may be useful in adequately estimating exposure. The objective of this study was to develop a model to predict the individual anidulafungin exposure in critically ill patients using limited-sampling strategies. Pharmacokinetic data were derived from 20 critically ill patients with invasive candidiasis treated with anidulafungin. These data were used to develop a two-compartment model in MW\Pharm using an iterative 2-stage Bayesian procedure. Limited- sampling strategies were subsequently investigated using two methods, a Bayesian analysis and a linear regression analysis. The best possible strategies for these two methods were evaluated by a Bland-Altman analysis for correlation of the predicted and observed AUC from 0 to 24 h (AUC(0-24)) values. Anidulafungin exposure can be adequately estimated with the concentration from a single sample drawn 12 h after the start of the infusion either by linear regression (R-2 = 0.99; bias, 0.05%; root mean square error [RMSE], 3%) or using a population pharmacokinetic model (R-2 = 0.89; bias, -0.1%; RMSE, 9%) in critically ill patients and also in less severely ill patients, as reflected by healthy volunteers. Limited sampling can be advantageous for future studies evaluating the pharmacokinetics and pharmacodynamics of anidulafungin and for therapeutic drug monitoring in selected patients

Inflammation Is Associated with Voriconazole Trough Concentrations

Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. Inflammation may be a contributing factor, as inflammatory stimuli can change the activities and expression levels of cytochrome P450 isoenzymes. We explored the correlation between inflammation, reflected by C-reactive protein (CRP) concentrations, and voriconazole trough concentrations. A retrospective chart review of patients with at least one steady-state voriconazole trough concentration and a CRP concentration measured on the same day was performed. A total of 128 patients were included. A significantly (