Uit de mest- en mineralenprogramma's : Europese Kaderrichtlijn Water: Gevolgen voor landbouw, natuur, recreatie en visserij

Implementatie van de Europese Kaderrichtlijn Water (KRW) in Nederland kan grote gevolgen hebben voor de landbouw. Dat blijkt uit een quick-scan van Alterra en LEI van Wageningen UR, 'Aquarein, gevolgen van de Europese Kaderrichtlijn Water voor landbouw, natuur, recreatie en visserij'. Om in Nederland tot een goede ecologische toestand van de oppervlaktewateren te komen moet bij de in deze studie gemaakte veronderstellingen de emissie van nutriënten drastisch worden gereduceer

Monitoring stroomgebieden : een tussenrapport : meerjaren monitoringsprogramma naar de uit- en afspoeling van nutriënten vanuit landbouwgronden in stroomgebieden en polders

In vier onderzoeksgebieden is alle bestaande kennis van het oppervlaktewatersysteem en de waterkwaliteit verzameld. Het betreft: de Drentse Aa, een zandgebied met lage nutriëntenbelasting; de Schuitenbeek, een zandgebied met hoge nutriëntenbelasting; de Krimpenerwaard, een veenpolder; Quarles van Ufford, een bemalen rivierkleigebied. Vervolgens zijn waar nodig extra veldmetingen gedaan. Deze aanvullende metingen hebben kennishiaten binnen de gebieden opgevuld en zijn ingezet voor de bouw van een model dat de relaties tussen alle onderdelen in het oppervlaktewatersysteem betrouwbaar en gedetailleerd weergeeft. Dat model is gebouwd als afgeleide van een bestaand, landelijk model (STONE), dat in fases is verfijnd en uitgebreid op basis van steeds gedetailleerdere systeemkennis en gebiedsdata. Aanpassingen in het model zijn steeds getoetst aan meetgegevens uit het gebied, waarmee direct duidelijk werd of de aanpassing resulteerde in een beter werkend model

Inhibition of Alpha-Msh Secretion Is Associated with Increased Cyclic-Amp Egress from the Neurointermediate Lobe of Xenopus-Laevis

Contains fulltext : 27659.pdf (publisher's version ) (Open Access

Origin and outcome of metastatic tumours to the testes:a nationwide study

ObjectivesTo perform a retrospective cohort analysis for metastatic tumours in the testes to explore the timing, presentation and prognosis of this particular type of metastases and the factors that influence outcome.Patients and methodsA nationwide retrospective review of pathology reports of patients with pathologically confirmed metastases to the testis between 1991 and 2021 was performed. Data were collected from the Dutch nationwide pathology databank (PALGA) and the Netherlands Cancer Registry. Log-rank testing and Kaplan–Meier analyses were used to assess overall survival (OS), and Cox proportional hazard models were used for multivariate survival analysis.ResultsA total of 175 patients with a testicular metastasis were included. The median (range) age at diagnosis of testicular metastasis was 67 (3–88) years. Testicular metastases originated from a variety of primary tumours, although most frequently from the prostate (40.6%), kidney (13.7%), colon (10.3%), bladder (7.4%) and skin (5.7%). Synchronous testicular metastasis was detected in 53 cases, while 114 metachronous lesions were found after a median (interquartile range) interval of 22 (1–53) months after the original cancer diagnosis. OS after the diagnosis of a testicular metastasis was poor, with a median survival of 14.2 months (95% confidence interval 10.2–18.3). Primary tumour origin was an independent factor for survival, with worst survival for patients with primary skin, bladder and colon cancer.ConclusionTesticular metastases are very uncommon and arise mainly from primary tumours anatomically close to the testes. Most patients develop metachronous testicular metastasis at an oligometastatic disease stage. These metastases are invariably associated with poor survival

Multi-RAT IoT -- What's to Gain? An Energy-Monitoring Platform

Multiple LPWANs have been rolled out to support the variety of IoT applications that are crucial to the ongoing digital transformation. These networks vary largely in terms of quality-of-service, throughput and energy-efficiency. To cover all LPWAN use-cases most optimally, multiple networks can be combined into a multiple radio access technology (multi-RAT) solution. In particular environmental monitoring in both smart city and remote landscapes. We present and share such a multi-RAT platform. To derive an accurate profile of the multi-RAT opportunities in various scenarios, in the-field network parameter are monitored. The platform collects per-packet energy-consumption, packet delivery ratio (PDR) and other parameters of LoRaWAN, NB-IoT and Sigfox. Our preliminary measurements demonstrate the validity of using a multi-RAT solution. For example, we illustrate the potential energy savings when adopting multi-RAT in various scenarios

Association of quantifiable prostate MRI parameters with any and large cribriform pattern in prostate cancer patients undergoing radical prostatectomy

Purpose: Cribriform pattern has recently been recognized as an important independent risk factor for prostate cancer (PCa) outcome. This study aimed to identify the association of quantifiable prostate magnetic resonance imaging (MRI) parameters with any and large cribriform pattern at radical prostatectomy (RP) specimens. Methods: Preoperative prostate MRI's from 188 men undergoing RP between 2010 and 2018 were retrospectively acquired. RP specimens of the patients were revised for Gleason score (GS), and presence of any and large cribriform pattern. MRI parameters such as MRI visibility, PI-RADS score, lowest apparent diffusion coefficient (ADC) value, lesion size, and radiologic extra-prostatic extension (EPE) were reviewed. The association of prostate MRI parameters for presence of any and large cribriform pattern at RP was analysed using logistic regression. Results: 116/188 (61.7%) PCa patients had any cribriform and 36/188 (19.1%) large cribriform pattern at RP. 171/188 (91.0%) men had MRI-visible lesions; 111/116 (95.7%) tumours with any and 36/36 (100%) with large cribriform pattern were visible at MRI. PCa with any and large cribriform pattern both had lower ADC values than those without (p &lt; 0.001). In adjusted analysis, lowest ADC value was as an independent predictor for any cribriform (Odds Ratio (OR) 0.2, 95% Confidence Interval (CI) 0.1–0.8; p = 0.01) and large cribriform pattern (OR 0.2, 95% CI 0.1–0.7; p = 0.01), while other parameters were not. Conclusions: The majority of PCa with cribriform pattern at RP were visible at MRI, and lowest ADC value was an independent predictor for both any and large cribriform pattern.</p

The Role of Pathology in Small Renal Mass Laparoscopic Cryoablation

Objective. We evaluated histological outcome of intraoperative biopsies at laparoscopic renal mass cryoablation (LCA), prevalence of peritumoral fat tissue invasion, and risk of tract seeding. Methods. Patients were biopsied 3–5 times (16-gauge). Histology was analyzed by general pathologists and reviewed. Peritumoral fat was histologically examined. The trocar used for biopsy-guidance was examined by cytology. Records were studied for reporting tract metastasis. Results. 77 biopsied renal masses with mean ± SD diameter 30 ± 7.4 mm were histologically classified by primary and review pathology revealing 64 and 62 malignancies, 13 and 15 benign lesions, respectively. In 30/34, the fat covered a carcinoma but revealed no malignancy. Cytology showed no malignant cells but was inconclusive in 1 case. No tract metastasis occurred. Conclusions. The use of an intraoperative biopsy protocol provides histological diagnosis of all renal masses. No existence of peritumoral fat tissue invasion or tract seeding was found