Фактори, які кондиціонують поліваріантність ефектів бальнеотерапевтичного комплексу курорту Трускавець на інтракардіальну та центральну гемодинаміку

Показано что, разнообразие эффектов курса бальнеотерапии на курорте Трускавець на гемодинамику может быть сведено методом кластерного анализа к четырем вариантам. Методом дискриминантного анализа выявлены 15 исходных параметров гемодинамики, вегетативной регуляции и обмена электролитов и липидов, закономерно обуславливающих тот или иной вариант бальнеоэффекта.The method of an echocardiography studies reactings intracardial and central hemodynamics of the man on a course balneotherapy on a spa Truskavets'. Outgoing from shifts of main parameters: an index of contractility (IC), frequency of a rhythm (FR), middledynamic pressure (Pm), general peripheral resistance of vessels (GPRV), expulsion time (ET), enddyastolic (EDV), shock (SV) volumes of heart and cardiac output (CО) - is selected 4 types of reacting. Hypotensive bradycardiо-antikinetic reacting registered for 34,8% of persons, is characterized reduce of Pm, rhythm, ET and CО associated with absence of changes SV, EDV, GPRV and IC. For antiresistive tachycardiо-prokinetic type (30,3% of cases) is characteristic combination of increase of a FR, ET and CО with a considerable decrease GPRV. At proresistive antiinotropic tachycardiо-antikinetic type (19,7% of faces) is essentially increased GPRV and FR, reduced IC, ET, EDV, SV and CО. For 15,2% of faces is established antiresistive proinotropic prokinetic type described by a increase of IC, EDV, SV, FR and CО and decrease of GPRV. The type of effects are conditionized by constellation of 15 initial parameters of haemodynamic, vegetative regulation and exchange of lipides and electrolytes and are prognozed by method of disccriminant analysis (correctly 83,3%)

Somatostatin analogues for receptor targeted photodynamic therapy

Photodynamic therapy (PDT) is an established treatment modality, used mainly for anticancer therapy that relies on the interaction of photosensitizer, light and oxygen. For the treatment of pathologies in certain anatomical sites, improved targeting of the photosensitizer is necessary to prevent damage to healthy tissue. We report on a novel dual approach of targeted PDT (vascular and cellular targeting) utilizing the expression of neuropeptide somatostatin receptor (sst2) on tumor and neovascular-endothelial cells. We synthesized two conjugates containing the somatostatin analogue [Tyr3]-octreotate and Chlorin e6 (Ce6): Ce6-K3-[Tyr3]-octreotate (1) and Ce6-[Tyr3]-octreotate-K3-[Tyr3]-octreotate (2). Investigation of the uptake and photodynamic activity of conjugates in-vitro in human erythroleukemic K562 cells showed that conjugation of [Tyr3]-octreotate with Ce6 in conjugate 1 enhances uptake (by a factor 2) in cells over-expressing sst2 compared to wild-type cells. Co-treatment with excess free Octreotide abrogated the phototoxicity of conjugate 1 indicative of a specific sst2-mediated effect. In contrast conjugate 2 showed no receptor-mediated effect due to its high hydrophobicity. When compared with un-conjugated Ce6, the PDT activity of conjugate 1 was lower. However, it showed higher photostability which may compensate for its lower phototoxicity. Intra-vital fluorescence pharmacokinetic studies of conjugate 1 in rat skin-fold observation chambers transplanted with sst2+ AR42J acinar pancreas tumors showed significantly different uptake profiles compared to free Ce6. Co-treatment with free Octreotide significantly reduced conjugate uptake in tumor tissue (by a factor 4) as well as in the chamber neo-vasculature. These results show that conjugate 1 might have potential as an in-vivo sst2 targeting photosensitizer conjugate

Quantized Roentgen Effect in Bose-Einstein Condensates

A classical dielectric moving in a charged capacitor can create a magnetic field (Roentgen effect). A quantum dielectric, however, will not produce a magnetization, except at vortices. The magnetic field outside the quantum dielectric appears as the field of quantized monopoles

Flux flow resistivity and vortex viscosity of high-Tc films

The flux flow regime of high-T$_{\rm c}$ samples of different normal state resistivities is studied in the temperature range where the sign of the Hall effect is reversed. The scaling of the vortex viscosity with normal state resistivity is consistent with the Bardeen-Stephen theory. Estimates of the influence of possible mechanisms suggested for the sign reversal of the Hall effect are also given.Comment: 3 pages. 4 figures upon reques