Laboratory Analysis of Risky Driving at 0.05% and 0.08% Blood Alcohol Concentration

Background—The public health costs associated with alcohol-related traffic crashes are a continuing problem for society. One harm reduction strategy has been to employ per se limits for blood alcohol concentrations (BACs) at which drivers can legally operate motor vehicles. This limit is currently 0.08% in all 50 US states. Recently, the National Transportation Safety Board proposed lowering the legal limit to 0.05 % (NTSB, 2013). While research has well-validated the ability of alcohol to impair driving performance and heighten crash-risk at these BACs, relatively little is known about the degree to which alcohol might increase drivers’ risk-taking. Methods—Risk-taking was examined in 20 healthy adults who were each tested in a driving simulator following placebo and two doses of alcohol calculated to yield peak BACs of 0.08% and 0.05%, the respective current and proposed BAC limits. The drive test emphasized risk-taking by placing participants in a multiple-lane, high-traffic environment. The primary measure was how close drivers maneuvered relative to other vehicles on the road (i.e., time-to-collision, TTC). Results—Alcohol increased risk-taking by decreasing drivers’ TTC at the 0.08% target BAC relative to placebo. Moreover, risk-taking at the 0.05% target was less than risk-taking at 0.08% target BAC. Conclusions—These findings provide evidence that reducing the legal BAC limit in the USA to 0.05% would decrease risk-taking among drivers. A clearer understanding of the dose-response relationship between various aspects of driving behaviors, such as drivers’ accepted level of risk while driving, is an important step to improving traffic safety

TOWARD A THEORY OF JUST COMMUNICATION: A CASE STUDY OF NATO, MULTINATIONAL PUBLIC RELATIONS, AND ETHICAL MANAGEMENT OF INTERNATIONAL CONFLICT

This dissertation used a qualitative, case study to explore how the North Atlantic Treaty Organization (NATO) applied strategic public relations management during peace operations in post-war Bosnia-Herzegovina, 1995 to 1996. The purpose of this research was to propose a model of ethical communication that extended the excellence theory in public relations and contributed to a global public relations theory. This proposed model relies on an ethical framework for moral reasoning that helps justify public relations decisions. The model incorporates interdisciplinary concepts drawn from the situational theory of publics, the excellence theory, an activist theory of communication, a moral theory of just war, and game theory. Fourteen long interviews, four elite interviews, and three focus group interviews explained how NATO applied principles of the excellence theory and global theory in public relations, how organizational culture and conflict influenced NATO communication management, and how NATO leaders made communication decisions. It had been assumed that NATO's political-military, authoritarian nature would lead the alliance to reject symmetrical communication and to adopt asymmetrical communication strategies. The study found that NATO mixed symmetrical communication - and other principles of the excellence theory and global public relations - with asymmetrical strategies like coercion to manage conflict. The study also identified a constellation of divided cultures among NATO's 26 member nations that influenced alliance public relations. Furthermore, senior NATO leaders relied heavily on intuitive knowledge when making decisions, leaving communication choices vulnerable to ethical relativism. In conclusion, this study has significant implications for theory and practice. The integrated, coercive-collaborative model of ethical communication developed through this study offers normative and positive value for managing asymmetrical conflict situations in which one or more parties demonstrate no willingness to cooperate. This model retains the value of excellence in public relations, which produces strategic, long-term, symmetrical relationships. Demonstrating how symmetrical outcomes can be achieved through ethical application of short-term coercive as well as collaborative communication tactics represents a major leap forward for the excellence theory. Practical implications of this study extend to any organization that relies on communication to manage conflict, build strategic relationships, and reduce costs - especially in a global, multinational context

Deep cover bleeder entry performance and support loading: A case study

Several questions have emerged in relation to deep cover bleeder entry performance and support loading: how well do current modeling procedures calculate the rear abutment extent and loading? Does an improved understanding of the rear abutment extent warrant a change in standing support in bleeder entries? To help answer these questions and to determine the current utilization of standing support in bleeder entries, four bleeder entries at varying distances from the startup room were instrumented, observed, and numerically modeled. This paper details observations made by NIOSH researchers in the bleeder entries of a deep cover longwall panel—specifically data collected from instrumented pumpable cribs, observations of the conditions of the entries, and numerical modeling of the bleeder entries during longwall extraction. The primary focus was on the extent and magnitude of the abutment loading expe- rienced by the standing support. As expected, the instrumentation of the standing supports showed very little loading relative to the capacity of the standing supports—less than 23 Mg load and 2.54 cm conver- gence. The Flac3D program was used to evaluate these four bleeder entries using previously defined mod- eling and input parameter estimation procedures. The results indicated only a minor increase in load during the extraction of the longwall panel. The model showed a much greater increase in stress due to the development of the gateroad and bleeder entries, with about 80% of the increase associated with development and 20% with longwall extraction. The Flac3D model showed very good correlation between expected gateroad loading during panel extraction and that expected based on previous studies. The results of this study showed that the rear abutment stress experienced by this bleeder entry design was minimal. The farther away from the startup room, the lower the applied load and smaller the con- vergence in the entry if all else is held constant. Finally, the numerical modeling method used in this study was capable of replicating the expected and measured results near seam

Final Calibration of the Berkeley Extreme and Far-Ultraviolet Spectrometer on the ORFEUS-SPAS I and II Missions

The Berkeley Extreme and Far-Ultraviolet Spectrometer (BEFS) flew as part of the ORFEUS telescope on the ORFEUS-SPAS I and II space-shuttle missions in 1993 and 1996, respectively. The data obtained by this instrument have now entered the public domain. To facilitate their use by the astronomical community, we have re-extracted and re-calibrated both data sets, converted them into a standard (FITS) format, and placed them in the Multimission Archive at Space Telescope (MAST). Our final calibration yields improved wavelength scales and effective-area curves for both data sets.Comment: To appear in the January 2002 issue of the PASP. 17 pages with 9 embedded postscript figures; uses emulateapj5.st

ORFEUS-II Far-Ultraviolet Observations of 3C273: 1. Interstellar and Intergalactic Absorption Lines

We present the first intermediate-resolution (lambda / 3000) spectrum of the bright quasi-stellar object 3C273 at wavelengths between 900 and 1200 A. Observations were performed with the Berkeley spectrograph aboard the ORFEUS-SPAS II mission. We detect Lyman beta counterparts to previously-identified intergalactic Lyman-alpha features at cz = 19900, 1600, and 1000 km/s; counterparts to other putative Lyman-alpha clouds along the sight line are below our detection limit. The strengths of the two very low redshift Lyman-beta features, which are believed to arise in Virgo intracluster gas, exceed preflight expectations, suggesting that the previous determination of the cloud parameters may underestimate the true column densities. A curve-of-growth analysis sets a minimum H I column density of 4 E14/cm^2 for the 1600 km/s cloud. We find marginally significant evidence for Galactic H_2 along the sight line, with a total column density of about 1 E15/cm^2. We detect the stronger interstellar O VI doublet member unambiguously; the weaker member is blended with other features. If the Doppler b value for O VI is comparable to that determined for N V then the O VI column density is 7 +/- 2 E14/cm^2, significantly above the only previous estimate. The O VI / N V ratio is about 10, consistent with the low end of the range observed in the disk. Additional interstellar species detected for the first time toward 3C273 (at modest statistical significance) include P II, Fe III, Ar I, and S III.Comment: LaTeX file, 11 pages, 4 encapsulated PostScript figures. Uses aaspp4.sty and astrobib.sty. (Astrobib is available from http://www.stsci.edu/software/TeX.html .) The ORFEUS telescope is described at http://sag-www.ssl.berkeley.edu/orfeus/ . To appear in ApJ (Letters

Development and piloting of an exposure database and surveillance system for DOE cleanup operations

An industrial hygiene exposure database and surveillance system was developed in partnership between National Institute for Occupational Safety and Health (NIOSH)-funded independent investigators and practicing industrial hygienists at the Rocky Flats Environmental Technology Site (RFETS) in Golden, Colo. RFETS is a former U.S. Department of Energy nuclear weapons plant that is now in cleanup phase. This project is presented as a case study in the development of an exposure database and surveillance system in terms that are generalizable to most other industries and work contexts. Steps include gaining organizational support; defining system purpose and scope; defining database elements and coding; planning practical and efficient analysis strategies; incorporating reporting capabilities; and anticipating communication strategies that maximize the probability that surveillance findings will feed back to preventive applications. For each of these topics, the authors describe both general considerations as well as the specific choices made for this system. An important feature of the system is a two-tier task-coding scheme comprising 33 categories of task groups. Examples of grouped analyses of exposure data captured during the system pilot period demonstrate applications to exposure control, medical surveillance, and other preventive measures. Reprinted by permission of the publisher

Impaired Bub1 Function In vivo Compromises Tension-Dependent Checkpoint Function Leading to Aneuploidy and Tumorigenesis

Bub1 is a serine/threonine kinase originally described as a core component of the spindle assembly checkpoint (SAC) mechanism in yeast. Bub1 binding at kinetochores has been reported to be required for SAC function and localization of other SAC components. A proper SAC is believed to be essential for murine embryonic development, as all previously described null mutations in SAC components in mice cause embryonic lethality. We produced mice harboring a Bub1 mutant allele lacking exons 2 and 3, resulting in a hypomorphic mutant expressed at <5% of wild-type levels. Despite this significant reduction, homozygous mutant animals are viable on a mixed 129P2/B6 or FVB background but display increased tumorigenesis with aging, whereas mice with a C57Bl/6J background die perinatally. Bub1 mutant murine embryonic fibroblasts (MEFs) display defects in chromosome congression to the metaphase plate, severe chromosome missegregation, and aneuploidy accompanied by high levels of premature senescence. Mutant MEFs have a robust SAC in response to nocodazole treatment but an impaired response to Taxol. Mutant MEFs also show reduced kinetochore localization of BubR1, but not of Mad2. The significant reduction in SAC response to Taxol, but not nocodazole, coupled with the reduced binding of BubR1, but not Mad2, indicates that Bub1 is particularly critical for the SAC response to a lack of tension on kinetochores. Thus, Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer

Using the surface profiles of modern ice masses to inform palaeo-glacier reconstructions

Morphometric study of modern ice masses is useful because many reconstructions of glaciers traditionally draw on their shape for guidance Here we analyse data derived from the surface profiles of 200 modern ice masses-valley glaciers icefields ice caps and ice sheets with length scales from 10(0) to 10(3) km-from different parts of the world Four profile attributes are investigated relief span and two parameters C* and C that result from using Nye s (1952) theoretical parabola as a profile descriptor C* and C respectively measure each profile s aspect ratio and steepness and are found to decrease in size and variability with span This dependence quantifies the competing influences of unconstrained spreading behaviour of ice flow and bed topography on the profile shape of ice masses which becomes more parabolic as span Increases (with C* and C tending to low values of 2 5-3 3 m(1/2)) The same data reveal coherent minimum bounds in C* and C for modern ice masses that we develop into two new methods of palaeo glacier reconstruction In the first method glacial limits are known from moraines and the bounds are used to constrain the lowest palaeo ice surface consistent with modern profiles We give an example of applying this method over a three-dimensional glacial landscape in Kamchatka In the second method we test the plausibility of existing reconstructions by comparing their C* and C against the modern minimum bounds Of the 86 published palaeo ice masses that we put to this test 88% are found to be plausible The search for other morphometric constraints will help us formalise glacier reconstructions and reduce their uncertainty and subjectiveness (C) 2010 Elsevier Ltd All rights reserve