105 research outputs found
A perspective on counting catalytic active sites and rates of reaction using x-ray spectroscopy
Identification of active sites and phases in heterogeneous catalysts and the understanding of the reaction mechanism remain highly challenging. In most catalysts, the existence of a multitude of surface species, which are dynamic in relation to reaction conditions, presents a challenge of distinguishing those that are involved in the catalytic cycle from those which are spectators. The emergence of the field of single-site catalysts potentially eliminates these issues, although it can be argued that these systems remain dynamic and that multiple speciation, each a candidate for the active site, often remains a consideration. A perspective on how X-ray spectroscopy and characterization tools in general, can be used to correlate the number of active sites and the rate of their formation, in single-site and redox catalyst systems, is presented. The importance of observing proportionality between spectra features and the reaction rate, to differentiate between active sites and spectator species is discussed. Performing characterisation under catalyticly relevant conditions on structures that are demonstrably representative of actual catalysts is essential
Hard x-ray photon-in-photon-out spectroscopy with lifetime resolution – of XAS, XES, RIXSS and HERFD
Spectroscopic techniques that aim to resolve the electronic configuration and local coordination of a central
atom by detecting inner-shell radiative decays following photoexcitation using hard X-rays are presented. The
experimental setup requires an X-ray spectrometer based on perfect crystal Bragg optics. The possibilities arising from
non-resonant (X-Ray Emission Spectroscopy - XES) and resonant excitation (Resonant Inelastic X-Ray Scattering
Spectroscopy – RIXSS, High-Energy-Resolution Fluorescence Detected (HERFD) XAS) are discussed when the
instrumental energy broadenings of the primary (beamline) monochromator and the crystal spectrometer for x-ray
emission detection are on the order of the core hole lifetimes of the intermediate and final electronic states. The small
energy bandwidth in the emission detection yields line-sharpened absorption features. In transition metal compounds,
electron-electron interactions as well as orbital splittings and fractional population can be revealed. Combination with
EXAFS spectroscopy enables to extent the k-range beyond unwanted absorption edges in the sample that limit the
EXAFS range in conventional absorption spectroscopy
Recommended from our members
Probing the dynamics of plasmon-excited hexanethiol-capped gold nanoparticles by picosecond X-ray absorption spectroscopy
Picosecond X-ray absorption spectroscopy (XAS) is used to investigate the electronic and structural dynamics initiated by plasmon excitation of 1.8 nm diameter Au nanoparticles (NPs) functionalised with 1-hexanethiol. We show that 100 ps after photoexcitation the transient XAS spectrum is consistent with an 8% expansion of the Au-Au bond length and a large increase in disorder associated with melting of the NPs. Recovery of the ground state occurs with a time constant of ∼1.8 ns, arising from thermalisation with the environment. Simulations reveal that the transient spectrum exhibits no signature of charge separation at 100 ps and allows us to estimate an upper limit for the quantum yield (QY) of this process to be <0.1
Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: Assessment by a novel clinical tool
Background: Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa (VIM-PA) can cause nosocomial infections and may be responsible for increased mortality. Multidrug resistance in VIM-PA complicates treatment. We aimed to assess the contribution of VIM-PA to mortality in patients in a large tertiary care hospital in the Net
High-resolution genomic microarrays for X-linked mental retardation.
Contains fulltext :
52697.pdf (publisher's version ) (Closed access)Developments in genomic microarray technology have revolutionized the study of human genomic copy number variation. This has significantly affected many areas in human genetics, including the field of X-linked mental retardation (XLMR). Chromosome X-specific bacterial artificial chromosomes microarrays have been developed to specifically test this chromosome with a resolution of approximately 100 kilobases. Application of these microarrays in X-linked mental retardation studies has resulted in the identification of novel X-linked mental retardation genes, copy number variation at known X-linked mental retardation genes, and copy number variations harboring as yet unidentified X-linked mental retardation genes. Further enhancements in genomic microarray analysis will soon allow the reliable analysis of all copy number variations throughout this chromosome at the kilobase or single exon resolution. In this review, we describe the developments in this field and specifically highlight the impact of these microarray studies in the field of X-linked mental retardation
- …