The history of paediatric trauma care in Cape Town

Trauma is a leading cause of morbidity, mortality and disability in childhood. In most developed countries where 18% of the population are in the age group 0 - 15 years, injury exceeds all other causes of childhood mortality. In the developing countries of Africa, however, children aged 0 - 15 years constitute 43% of the population and trauma has an even bigger impact on child health.There is an erroneous perception that trauma is not a major health problem in Africa, derived from undue emphasis on mortality statistics alone. Yet, the impact of trauma ought to be measured not only in terms of death, but also the tremendous morbidity and disability caused by injuries, and their socioeconomic consequences

Profile of children with head injuries treated at the trauma unit of Red Cross War Memorial Children's Hospital

Objective. To describe the profile of childhood head injury patients treated in a trauma unit. Design. A retrospective record-based study. Setting. The trauma unit of the Red Cross War Memorial Children’s Hospital. Subjects. Children (under 13 years of age) presenting with head injuries between January 1991 and December 2001. Results. Of the almost 94 000 records, more than one-third were children presenting with head injuries. Fifty-nine per cent were boys, with more than half the sample under 5 years of age. The majority of children presented with superficial lacerations and abrasions, mostly affecting the scalp and skull. Injuries were mainly caused by falls from a variety of heights, and traffic-related injuries. Almost twothirds of traffic-related injuries involved children as pedestrians being struck by a motor vehicle. More than 60% of injuries occurred in or around the child’s own home. Conclusions. Head injuries in children are a significant cause of morbidity. Prevention, especially in the home and on the streets, needs urgent attention

Quantitative NME microscopy of iron transport in methanogenic aggregates

Transport of micronutrients (iron, cobalt, nickel, etc.) within biofilms matrixes such as methanogenic granules is of high importance, because these are either essential or toxic for the microorganisms living inside the biofilm. The present study demonstrates quantitative measurements of metal transport inside these biofilms using T1 weighted 3D RARE. It is shown that iron(II)-EDTA diffusion within the granule is independent of direction or the inner structure of the granules. Assuming position dependence of the spin-lattice relaxivity, Fick’s law for diffusion in a sphere can be applied to simulate the diffusion within the methanogenic granules under investigation. A relatively low diffusion coefficient of 2.5*10-11 m2·s-1 was obtained for iron diffusion within the methanogenic granul

The effects of foundation size on the seismic performance of buildings considering the soil-foundation-structure interaction

Copyright © 2016 Techno-Press, Ltd. Shallow footings are one of the most common types of foundations used to support mid-rise buildings in high risk seismic zones. Recent findings have revealed that the dynamic interaction between the soil, foundation, and the superstructure can influence the seismic response of the building during earthquakes. Accordingly, the properties of a foundation can alter the dynamic characteristics (natural frequency and damping) of the soil-foundation-structure system. In this paper the influence that shallow foundations have on the seismic response of a mid-rise moment resisting building is investigated. For this purpose, a fifteen storey moment resisting frame sitting on shallow footings with different sizes was simulated numerically using ABAQUS software. By adopting a direct calculation method, the numerical model can perform a fully nonlinear time history dynamic analysis to realistically simulate the dynamic behaviour of soil, foundation, and structure under seismic excitations. This three-dimensional numerical model accounts for the nonlinear behaviour of the soil medium and structural elements. Infinite boundary conditions were assigned to the numerical model to simulate free field boundaries, and appropriate contact elements capable of modelling sliding and separation between the foundation and soil elements are also considered. The influence of foundation size on the natural frequency of the system and structural response spectrum was also studied. The numerical results for cases of soil-foundation-structure systems with different sized foundations and fixed base conditions (excluding soil-foundation-structure interaction) in terms of lateral deformations, inter-storey drifts, rocking, and shear force distribution of the structure were then compared. Due to natural period lengthening, there was a significant reduction in the base shears when the size of the foundation was reduced. It was concluded that the size of a shallow foundation influences the dynamic characteristics and the seismic response of the building due to interaction between the soil, foundation, and structure, and therefore design engineer should carefully consider these parameters in order to ensure a safe and cost effective seismic design

From the pursuit of excellence to the quest for significance: Promotion of a Childsafe South Africa

Trauma represents a major burden of disease in South Africa. Children are disproportionately affected by trauma; rightly, childhood trauma can be referred to as ‘the neglected childhood killer disease’. Unlike the field of infectious diseases, where vaccinations and prevention are the norm, paediatric trauma is usually ignored and prevention strategies are scarce. In this article, we review paediatric trauma and its effect on our society in light of the development of more effective child safety promotion strategies

Energy metabolism in human pluripotent stem cells and their differentiated counterparts

Background: Human pluripotent stem cells have the ability to generate all cell types present in the adult organism, therefore harboring great potential for the in vitro study of differentiation and for the development of cell-based therapies. Nonetheless their use may prove challenging as incomplete differentiation of these cells might lead to tumoregenicity. Interestingly, many cancer types have been reported to display metabolic modifications with features that might be similar to stem cells. Understanding the metabolic properties of human pluripotent stem cells when compared to their differentiated counterparts can thus be of crucial importance. Furthermore recent data has stressed distinct features of different human pluripotent cells lines, namely when comparing embryo-derived human embryonic stem cells (hESCs) and induced pluripotent stem cells (IPSCs) reprogrammed from somatic cells. Methodology/Principal Findings: We compared the energy metabolism of hESCs, IPSCs, and their somatic counterparts. Focusing on mitochondria, we tracked organelle localization and morphology. Furthermore we performed gene expression analysis of several pathways related to the glucose metabolism, including glycolysis, the pentose phosphate pathway and the tricarboxylic acid (TCA) cycle. In addition we determined oxygen consumption rates (OCR) using a metabolic extracellular flux analyzer, as well as total intracellular ATP levels by high performance liquid chromatography (HPLC). Finally we explored the expression of key proteins involved in the regulation of glucose metabolism. Conclusions/Findings: Our results demonstrate that, although the metabolic signature of IPSCs is not identical to that of hESCs, nonetheless they cluster with hESCs rather than with their somatic counterparts. ATP levels, lactate production and OCR revealed that human pluripotent cells rely mostly on glycolysis to meet their energy demands. Furthermore, our work points to some of the strategies which human pluripotent stem cells may use to maintain high glycolytic rates, such as high levels of hexokinase II and inactive pyruvate dehydrogenase (PDH). © 2011 Varum et al

Animal attacks - a red herring of child abuse?

Injuries sustained as a result of attacks by domestic animals, particularly canines, are occasionally encountered at the Red Cross Children’s Hospital Trauma Unit in Cape Town. Less than 1% of admissions are directly attributable to animal attacks. Animal attacks causing lethal injuries are very rare and should be assessed carefully. We recently dealt with two fatalities attributed to animal attacks