4 research outputs found
The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice
Obesity is a worldwide public health problem whose prevalence rate has increased steadily
over the last few years. Therefore, it is urgent to improve the management of obesity and its
comorbidities, and plant-based treatments are receiving increasing attention worldwide. In this
regard, the present study aimed to investigate a well-characterized extract of Lavandula multifida (LME)
in an experimental model of obesity in mice and explore the underlying mechanisms. Interestingly,
the daily administration of LME reduced weight gain as well as improved insulin sensitivity and
glucose tolerance. Additionally, LME ameliorated the inflammatory state in both liver and adipose
tissue by decreasing the expression of various proinflammatory mediators (Il-6, Tnf-a, Il-1b, Jnk-1,
Ppara, Pparg, and Ampk) and prevented increased gut permeability by regulating the expression of
mucins (Muc-1, Muc-2, and Muc-3) and proteins implicated in epithelial barrier integrity maintenance
(Ocln, Tjp1, and Tff-3). In addition, LME showed the ability to reduce oxidative stress by inhibiting
nitrite production on macrophages and lipid peroxidation. These results suggest that LME may
represent a promising complementary approach for the management of obesity and its comorbidities.Junta de Andalucía (CTS 164), by the Instituto de Salud
Carlos III (ISCIII) (PI19.01058)Spanish Ministry of Economy and Competitiveness
(AGL2015-67995-C3-3-R)European Commission (FEDER/ERDF). The CIBEREHDInstituto de Salud Carlos II
Comprensión conceptual de estadística y métodos de decisión utilizando herramientas de gamificación para la adquisición de competencias en los grados de ciencias económicas y empresariales
El objetivo general del proyecto es mejorar la motivación y la actitud de los alumnos de los grados de ciencias sociales hacia las materias cuantitativas, así como su participación activa en el proceso de enseñanza-aprendizaje, individual y en grupo, con la finalidad última de incrementar su nivel de competencias y rendimiento