175,408 research outputs found
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Editorial for special issue on education and humour: Education and humour as tools for social awareness and critical consciousness in contemporary classrooms
It is not new to consider the instructive power of humour. Both Plato and Aristotle, through their superiority theories, saw the benefit of wit as a social corrective, although they remained suspicious of the uneducated laughter of the masses (Plato in Morreall 1987; Aristotle in Morreall 1987). This approach has informed traditions of satire and resistance humour in a myriad of contexts. Stott summarises the raison d'être of satire through its aim “to denounce folly and vice and urge ethical and political reform through the subjection of ideas to humorous analysis” (Stott 2005: 109). The political potential of humour is easily recognised as a rhetorical and communicative device, yet it seems odd that little stock has been placed academically or culturally in the idea of humour as an educative tool in other social and cultural contexts and, more specifically, in the classroom
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Sensitivity of North American monsoon rainfall to multisource sea surface temperatures in MM5
In this article, four continually processed sea surface temperature (SST) datasets, including the Reynolds SST (RYD), the global final analysis of skin temperature at oceans (FNL), and two Moderate Resolution Imaging Spectroradiometer (MODIS) Aqua SSTs retrieved from thermal infrared imagery (TIR) and midinfrared imagery (MIR), were compared. The results show variations from each other. In comparison with the RYD SST, the FNL data have -0.5° ∼ 0.5°C perturbations, while the TIR and MIR SSTs possess larger deviations of -2° ∼ 1°C, mainly due to algorithm and/or sensor differences in these SST datasets. A regional model, the fifth-generation Pennsylvania State University-Na tional Center for Atmospheric Research (Penn State-NCAR) Mesoscale Model (MM5), was used to investigate whether model atmospheric predictions, especially those concerning precipitation during the North American monsoon season, are sensitive to these SST variations. A comparison of rainfall, atmospheric height, temperature, and wind fields produced by model results, reanalysis data, and observations indicates that, at monthly scale, the model shows changes in the simulations for three consecutive years; in particular, rainfall amounts, timing, and even patterns vary at some specific regions. Forced by the MODIS Aqua midinfrared SST (MIR), which includes large regions with SST values lower than the conventional Reynolds SST, the MM5 rain field predictions show reduced errors over land and oceans compared to when the model is forced by other SST data. Specifically, rainfall estimates are improved over the offshore of southern Mexico, the Gulf of Mexico, the coastal regions of southern and eastern Mexico, and the southwestern U.S. monsoon active region, but only slightly improved over the monsoon core and the high-elevated Great Plains. Using MIR SST data, one is also capable of improving geopotential height and temperature fields in comparison wit he reanalysis data. © 2005 American Meteorological Society
The impact of gambling advertising: Problem gamblers report stronger impacts on involvement, knowledge, and awareness than recreational gamblers.
Although there is a general lack of empirical evidence that advertising influences gambling participation, the regulation of gambling advertising is hotly debated among academic researchers, treatment specialists, lobby groups, regulators, and policy makers. This study contributes to the ongoing debate by investigating perceived impacts of gambling advertising in a sample of gamblers drawn from the general population in Norway (n = 6,034). Three dimensions of advertising impacts were identified, representing perceived impacts on (a) gambling-related attitudes, interest, and behavior (‘Involvement’), (b) knowledge about gambling options and providers (‘Knowledge’), and (c) the degree to which people are aware of gambling advertising (‘Awareness’). Overall, impacts were strongest for the ‘Knowledge’ dimension, and, for all three dimensions, the impact increased with level of advertising exposure. Those identified as problem gamblers in the sample (n = 57) reported advertising impacts concerning ‘Involvement’ more than recreational gamblers, and this finding was not attributable to differences in advertising exposure. Additionally, younger gamblers reported stronger impacts on ‘Involvement’ and ‘Knowledge’ but were less likely to agree that they were aware of gambling advertising than older gamblers. Male gamblers were more likely than female gamblers to report stronger impacts on both ‘Involvement’ and ‘Knowledge’. These findings are discussed with regard to existing research on gambling advertising as well as their implications for future research and policy-making
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Radar Z-R relationship for summer monsoon storms in Arizona
Radar-based estimates of rainfall rates and accumulations are one of the principal tools used by the National Weather Service (NWS) to identify areas of extreme precipitation that could lead to flooding. Radar-based rainfall estimates have been compared to gauge observations for 13 convective storm events over a densely instrumented, experimental watershed to derive an accurate reflectivity-rainfall rate (i.e., Z-R) relationship for these events. The resultant Z-R relationship, which is much different than the NWS operational Z-R, has been examined for a separate, independent event that occurred over a different location. For all events studied, the NWS operational Z-R significantly overestimates rainfall compared to gauge measurements. The gauge data from the experimental network, the NWS operational rain estimates, and the improved estimates resulting from this study have been input into a hydrologic model to "predict" watershed runoff for an intense event. Rainfall data from the gauges and from the derived Z-R relation produce predictions in relatively good agreement with observed streamflows. The NWS Z-R estimates lead to predicted peak discharge rates that are more than twice as large as the observed discharges. These results were consistent over a relatively wide range of subwatershed areas (4-148 km2). The experimentally derived Z-R relationship may provide more accurate radar estimates for convective storms over the southwest United States than does the operational convective Z-R used by the NWS. These initial results suggest that the generic NWS Z-R relation, used nationally for convective storms, might be substantially improved for regional application. © 2005 American Meteorological Society
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Expression of proliferation-dependent antigens during cellular ageing of normal and progeroid human fibroblasts
Normal human fibroblasts display a limited lifespan in
culture, which is due to a steadily decreasing fraction of
cells that are able to proliferate. Using antibodies that react
with antigens present in proliferating cells only, in an
indirect immunofluorescence assay, we have estimated the
fraction of proliferating cells in cultures of normal human
fibroblasts. Furthermore, we have estimated the rate of
decline in the fraction of proliferating cells during the
process of cellular ageing by application of the assay to
normal human fibroblasts throughout their lifespan in
culture. Werner’s Syndrome is an autosomal recessive
disease in which individuals display symptoms of ageing
prematurely. Werner’s Syndrome fibroblasts display a
reduced lifespan in culture compared with normal human
fibroblasts. Like normal human fibroblasts, the growth of
Werner’s Syndrome fibroblasts is characterised by a
decreasing fraction of cells reacting with the proliferationassociated
antibodies throughout their lifespan in culture.
However, the rate of loss of proliferating cells in Werner’s
Syndrome fibroblasts during the process of cellular ageing
is accelerated 5- to 6-fold compared with the rate determined
for normal human fibroblasts
Population structures in the SARA and SARB reference collections of Salmonella enterica according to MLST, MLEE and microarray hybridization
In the 1980's and 1990's, population genetic analyses based on Multilocus Enzyme Electrophoresis (MLEE) provided an initial overview of the genetic diversity of multiple bacterial species, including Salmonella enterica. The genetic diversity within S. enterica subspecies enterica according to MLEE is represented by the SARA and SARB reference collections, each consisting of 72 isolates, which have been extensively used for comparative analyses. MLEE has subsequently been replaced by Multilocus Sequence Typing (MLST). Our initial MLST results indicated that some strains within the SARB collection differed from their published descriptions. We therefore performed MLST on four versions of the SARB collection from different sources and one collection of SARA, and found that multiple isolates in SARB and SARA differ in serovar from their original description, and other SARB isolates differed between different sources. Comparisons with a global MLST database allowed a plausible reconstruction of the serovars of the original collection. MLEE, MLST and microarrays were largely concordant at recognizing closely related strains. MLST was particularly effective at recognizing discrete population genetic groupings while the two other methods provided hints of higher order relationships. However, quantitative pair-wise phylogenetic distances differed considerably between all three methods. Our results provide a translation dictionary from MLEE to MLST for the extant SARA and SARB collections which can facilitate genomic comparisons based on archival insights from MLEE
Flow-distributed spikes for Schnakenberg kinetics
This is the post-print version of the final published paper. The final publication is available at link.springer.com by following the link below. Copyright @ 2011 Springer-Verlag.We study a system of reaction–diffusion–convection equations which combine a reaction–diffusion system with Schnakenberg kinetics and the convective flow equations. It serves as a simple model for flow-distributed pattern formation. We show how the choice of boundary conditions and the size of the flow influence the positions of the emerging spiky patterns and give conditions when they are shifted to the right or to the left. Further, we analyze the shape and prove the stability of the spikes. This paper is the first providing a rigorous analysis of spiky patterns for reaction-diffusion systems coupled with convective flow. The importance of these results for biological applications, in particular the formation of left–right asymmetry in the mouse, is indicated.RGC of Hong Kon
Dissolution dominating calcification process in polar pteropods close to the point of aragonite undersaturation
Thecosome pteropods are abundant upper-ocean zooplankton that build aragonite shells. Ocean acidification results in the lowering of aragonite saturation levels in the surface layers, and several incubation studies have shown that rates of calcification in these organisms decrease as a result. This study provides a weight-specific net calcification rate function for thecosome pteropods that includes both rates of dissolution and calcification over a range of plausible future aragonite saturation states (Omega_Ar). We measured gross dissolution in the pteropod Limacina helicina antarctica in the Scotia Sea (Southern Ocean) by incubating living specimens across a range of aragonite saturation states for a maximum of 14 days. Specimens started dissolving almost immediately upon exposure to undersaturated conditions (Omega_Ar,0.8), losing 1.4% of shell mass per day. The observed rate of gross dissolution was different from that predicted by rate law kinetics of aragonite dissolution, in being higher at Var levels slightly above 1 and lower at Omega_Ar levels of between 1 and 0.8. This indicates that shell mass is affected by even transitional levels of saturation, but there is, nevertheless, some partial means of protection for shells when in undersaturated conditions. A function for gross dissolution against Var derived from the present observations was compared to a function for gross calcification derived by a different study, and showed that dissolution became the dominating process even at Omega_Ar levels close to 1, with net shell growth ceasing at an Omega_Ar of 1.03. Gross dissolution increasingly dominated net change in shell mass as saturation levels decreased below 1. As well as influencing their viability, such dissolution of pteropod shells in the surface layers will result in slower sinking velocities and decreased carbon and carbonate fluxes to the deep ocean
A FAMILY OF CATION ATPASE-LIKE MOLECULES FROM PLASMODIUM-FALCIPARUM
Abstract. We report the nucleotide and derived amino acid sequence of the ATPase 1 gene from Plasmodium falciparum. The amino acid sequence shares homology with the family of "P-type cation transloeating ATPases in conserved regions important for nucleotide binding, conformational change, or phosphorylation. The gene, which is present on chromosome 5, has a product longer than any other reported for a P-type ATPase. Interstrain analysis from 12 parasite isolates by the polymerase chain reaction reveals that a 330-bp nucleotide sequence encoding three cytoplasmic regions conserved in cation ATPases (regions a-c) is of constant length. By contrast, another 360-bp sequence which is one of four regions we refer to as
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