Carl Rogers No Brasil", 2012 (eduardo Bandeira)

[No abstract available]191129130Bandeira, E., (2012) Carl Rogers No Brasil, , São Paulo: GRD Ediçõe

IGF2, LEPR, POMC, PPARG, and PPARGC1 gene variants are associated with obesity-related risk phenotypes in Brazilian children and adolescents

Association studies of genetic variants and obesity and/or obesity-related risk factors have yielded contradictory results. The aim of the present study was to determine the possible association of five single-nucleotide polymorphisms (SNPs) located in the IGF2, LEPR, POMC, PPARG, and PPARGC1 genes with obesity or obesity-related risk phenotypes. This case-control study assessed overweight (n=192) and normal-weight (n=211) children and adolescents. The SNPs were analyzed using minisequencing assays, and variables and genotype distributions between the groups were compared using one-way analysis of variance and Pearson's chi-square or Fisher's exact tests. Logistic regression analysis adjusted for age and gender was used to calculate the odds ratios (ORs) for selected phenotype risks in each group. No difference in SNP distribution was observed between groups. In children, POMC rs28932472(C) was associated with lower diastolic blood pressure (P=0.001), higher low-density lipoprotein (LDL) cholesterol (P=0.014), and higher risk in overweight children of altered total cholesterol (OR=7.35, P=0.006). In adolescents, IGF2 rs680(A) was associated with higher glucose (P=0.012) and higher risk in overweight adolescents for altered insulin (OR=10.08, P=0.005) and homeostasis model of insulin resistance (HOMA-IR) (OR=6.34, P=0.010). PPARG rs1801282(G) conferred a higher risk of altered insulin (OR=12.31, P=0.003), and HOMA-IR (OR=7.47, P=0.005) in overweight adolescents. PARGC1 rs8192678(A) was associated with higher triacylglycerols (P=0.005), and LEPR rs1137101(A) was marginally associated with higher LDL cholesterol (P=0.017). LEPR rs1137101(A) conferred higher risk for altered insulin, and HOMA-IR in overweight adolescents. The associations observed in this population suggested increased risk for cardiovascular diseases and/or type 2 diabetes later in life for individuals carrying these alleles

Fractions of carbohydrates and proteins from Brachiaria híbrida ‘Mulato II’ exposed to nitrogen doses and cutting regime

The objective of this research was to evaluate the fractionation of carbohydrates and nitrogenous compounds from Brachiaria híbrida ‘Mulato II’, managed in cutting regime and exposed to nitrogen doses. A completely randomized split plot design with a 2 x 4 factorial (2 cutting heights x 4 nitrogen doses) with three replicates was used. Treatments consisted in four N levels (0, 50, 100 and 150 kg N/ha), and two entry heights (0.40 and 0.50 m). Significant differences (pObjetivou-se com esta pesquisa avaliar o fracionamento de carboidratos e compostos nitrogenados Brachiaria híbrida ‘Mulato II’, sob regime de cortes e submetido a doses de nitrogênio. Utilizou-se um delineamento experimental inteiramente casualizado com arranjo fatorial 2 x 4 (2 alturas de corte x 4 doses de nitrogênio) com três repetições e parcelas subdivididas. Os tratamentos foram constituídos por quatro doses de N (0, 50, 100 e 150 kg/ha de N), com duas alturas de entrada (0,40 e 0,50 m). Ocorreram diferenças significativas (