Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD

Ajedrez y aprendizaje del área de matemáticas en estudiantes del segundo ciclo, Estudios Generales, Universidad San Martín de Porres, 2019

Este estudió pre experimental se propuso analizar la influencia del juego de ajedrez y aprendizaje del área matemáticas en los estudiantes universitarios, pensando en dicho fin se aplicó el pre y pos test a una muestra constituida de 40 estudiantes estudiantes segundo año de la Escuela Profesional de Administración Facultad de Ciencias Contables Económicas y Financieras de la Universidad San Martin de Porres, 2019, cuya información recolectada fue procesada con el programa SPSS, lo cual permitió aplicar prueba de diferencias de medias de T Student para muestras independientes. En los resultados se explica que la hipótesis general comprobó la influencia del ajedrez en el rendimiento académico del Área de Matemáticas, puesto que existe una diferencia de 1,76 puntos entre el grupo control y experimental. En las hipótesis específicas también confirmaron la influencia del ajedrez en el aprendizaje de las ecuaciones lineales, la derivada de una función, la aplicación de la derivada y el Cálculo Integral, puesto que sus diferencias de medias entre ambos grupos están en 0,49 puntos, 0,47 puntos, 1,47 puntos y 1,95 puntos, respectivamente. Por lo lo cual, se concluyó, que este actividad influye positivamente en el aprendizaje matemático y en sus dimensiones ecuaciones lineales, derivada de una función, aplicación de la derivada y cálculo integral. Palabras clave: Práctica, ajedrez, aprendizaje, matemáticas.</jats:p